Notoginsenoside R2CAS# 80418-25-3 |
- 20(R)-Notoginsenoside R2
Catalog No.:BCN3864
CAS No.:948046-15-9
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
| Cas No. | 80418-25-3 | SDF | Download SDF |
| PubChem ID | 21599925 | Appearance | White powder |
| Formula | C41H70O13 | M.Wt | 771.0 |
| Type of Compound | Triterpenoids | Storage | Desiccate at -20°C |
| Synonyms | 20(S)-Notoginsenoside R2; Ginsenoside Ng-R2 | ||
| Solubility | Soluble in methanol; insoluble in water | ||
| Chemical Name | (2S,3R,4S,5R)-2-[(2R,3R,4S,5S,6R)-2-[[(3S,5R,6S,8R,9R,10R,12R,13R,14R,17S)-3,12-dihydroxy-17-[(2S)-2-hydroxy-6-methylhept-5-en-2-yl]-4,4,8,10,14-pentamethyl-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-6-yl]oxy]-4,5-dihydroxy-6-(hydroxymethyl)oxan-3-yl]oxyoxane-3,4,5-triol | ||
| SMILES | CC(=CCCC(C)(C1CCC2(C1C(CC3C2(CC(C4C3(CCC(C4(C)C)O)C)OC5C(C(C(C(O5)CO)O)O)OC6C(C(C(CO6)O)O)O)C)O)C)O)C | ||
| Standard InChIKey | FNIRVWPHRMMRQI-PGOMJGFXSA-N | ||
| Standard InChI | InChI=1S/C41H70O13/c1-20(2)10-9-13-41(8,50)21-11-15-39(6)28(21)22(43)16-26-38(5)14-12-27(45)37(3,4)34(38)24(17-40(26,39)7)52-36-33(31(48)30(47)25(18-42)53-36)54-35-32(49)29(46)23(44)19-51-35/h10,21-36,42-50H,9,11-19H2,1-8H3/t21-,22+,23+,24-,25+,26+,27-,28-,29-,30+,31-,32+,33+,34-,35-,36+,38+,39+,40+,41-/m0/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
||
| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
||
| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | 1. Notoginsenoside R2 has neuroprotection against 6-OHDA-induced neurotoxicity, is associated with Notoginsenoside R2-mediated P90RSK and Nrf2 activation through MEK1/2-ERK1/2 pathways. |
| Targets | Nrf2 | MEK | ERK |
Notoginsenoside R2 Dilution Calculator
Notoginsenoside R2 Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 1.297 mL | 6.4851 mL | 12.9702 mL | 25.9403 mL | 32.4254 mL |
| 5 mM | 0.2594 mL | 1.297 mL | 2.594 mL | 5.1881 mL | 6.4851 mL |
| 10 mM | 0.1297 mL | 0.6485 mL | 1.297 mL | 2.594 mL | 3.2425 mL |
| 50 mM | 0.0259 mL | 0.1297 mL | 0.2594 mL | 0.5188 mL | 0.6485 mL |
| 100 mM | 0.013 mL | 0.0649 mL | 0.1297 mL | 0.2594 mL | 0.3243 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
Calcutta University
University of Minnesota
University of Maryland School of Medicine
University of Illinois at Chicago
The Ohio State University
University of Zurich
Harvard University
Colorado State University
Auburn University
Yale University
Worcester Polytechnic Institute
Washington State University
Stanford University
University of Leipzig
Universidade da Beira Interior
The Institute of Cancer Research
Heidelberg University
University of Amsterdam
University of Auckland
TsingHua University
The University of Michigan
Miami University
DRURY University
Jilin University
Fudan University
Wuhan University
Sun Yat-sen University
Universite de Paris
Deemed University
Auckland University
The University of Tokyo
Korea University
Notoginsenoside R2 is a newly isolated notoginsenoside from Panax notoginseng, showed neuroprotective effects against 6-OHDA-induced oxidative stress and apoptosis.
References:
[1]. Meng XB, et al. P90RSK and Nrf2 Activation via MEK1/2-ERK1/2 Pathways Mediated by Notoginsenoside R2 to Prevent 6-Hydroxydopamine-Induced Apoptotic Death in SH-SY5Y Cells. Evid Based Complement Alternat Med. 2013;2013:971712.
[2]. González-Burgos E, et al. Potential neuroprotective activity of Ginseng in Parkinson's disease: a review. J Neuroimmune Pharmacol. 2015 Mar;10(1):14-29.
- Notoginsenoside R1
Catalog No.:BCN1097
CAS No.:80418-24-2
- 13-O-p-Coumaroylplumieride
Catalog No.:BCN4338
CAS No.:80416-52-0
- Scorpioidine
Catalog No.:BCN2027
CAS No.:80405-18-1
- 7-Acetylscorpioidine
Catalog No.:BCN2028
CAS No.:80405-17-0
- Protoplumericin A
Catalog No.:BCN4572
CAS No.:80396-57-2
- Z-D-Thr-OH
Catalog No.:BCC2736
CAS No.:80384-27-6
- Obatoclax mesylate (GX15-070)
Catalog No.:BCC2234
CAS No.:803712-79-0
- 8beta-Tigloyloxyreynosin
Catalog No.:BCN7222
CAS No.:80368-31-6
- 2',3,5,6',7-Pentahydroxyflavanone
Catalog No.:BCN4337
CAS No.:80366-15-0
- NSC59984
Catalog No.:BCC6540
CAS No.:803647-40-7
- Tinnevellin glucoside
Catalog No.:BCN3414
CAS No.:80358-06-1
- 8-Acetonyldihydronitidine
Catalog No.:BCN3304
CAS No.:80330-39-8
- Calcium Levofolinate
Catalog No.:BCC4643
CAS No.:80433-71-2
- gamma-Diasarone
Catalog No.:BCN4339
CAS No.:80434-33-9
- Dynorphin A
Catalog No.:BCC7596
CAS No.:80448-90-4
- Padmatin
Catalog No.:BCN4340
CAS No.:80453-44-7
- Paeoniflorigenone
Catalog No.:BCN3933
CAS No.:80454-42-8
- Sapogenins Glycosides
Catalog No.:BCC5320
CAS No.:8047-15-2
- Fluticasone propionate
Catalog No.:BCC4907
CAS No.:80474-14-2
- Rubifolic acid
Catalog No.:BCN4341
CAS No.:80489-65-2
- Mezlocillin Sodium Monohydrate
Catalog No.:BCC5634
CAS No.:80495-46-1
- Tenacigenin B
Catalog No.:BCN4342
CAS No.:80508-42-5
- Glaucocalyxin B
Catalog No.:BCN8440
CAS No.:80508-81-2
- Veratrine
Catalog No.:BCN8444
CAS No.:8051-02-3
P90RSK and Nrf2 Activation via MEK1/2-ERK1/2 Pathways Mediated by Notoginsenoside R2 to Prevent 6-Hydroxydopamine-Induced Apoptotic Death in SH-SY5Y Cells.[Pubmed:24159358]
Evid Based Complement Alternat Med. 2013;2013:971712.
6-Hydroxydopamine (6-OHDA) is known to contribute to neuronal death in Parkinson's disease. In this study, we found that the preincubation of SH-SY5Y cells for 24 h with 20 mu M Notoginsenoside R2 (NGR2), which is a newly isolated notoginsenoside from Panax notoginseng, showed neuroprotective effects against 6-OHDA-induced oxidative stress and apoptosis. NGR2 incubation successively resulted in the activation of P90RSK, inactivation of BAD, and inhibition of 6-OHDA-induced mitochondrial membrane depolarization, thus preventing the mitochondrial apoptosis pathway. NGR2 incubation also led to the activation of Nrf2 and subsequent activity enhancement of phase II detoxifying enzymes, thus suppressing 6-OHDA-induced oxidative stress, and these effects could be removed by Nrf2 siRNA. We also found that the upstream activators of P90RSK and Nrf2 were the MEK1/2-ERK1/2 pathways but not the JNK, P38, or PI3K/Akt pathways. Interestingly, NGR2 incubation could also activate MEK1/2 and ERK1/2. Most importantly, NGR2-mediated P90RSK and Nrf2 activation, respective downstream target activation, and neuroprotection were reversed by the genetic silencing of MEK1/2 and ERK1/2 by using siRNA and PD98059 application. These results suggested that the neuroprotection elicited by NGR2 against 6-OHDA-induced neurotoxicity was associated with NGR2-mediated P90RSK and Nrf2 activation through MEK1/2-ERK1/2 pathways.
