Macrocarpal DCAS# 142647-71-0 |
- Macrocarpal O
Catalog No.:BCN7371
CAS No.:327622-65-1
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
| Cas No. | 142647-71-0 | SDF | Download SDF |
| PubChem ID | 454460 | Appearance | Yellow powder |
| Formula | C28H40O6 | M.Wt | 472.6 |
| Type of Compound | Sesquiterpenoids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | 2,4,6-trihydroxy-5-[1-[7-(2-hydroxypropan-2-yl)-1,4-dimethyl-3,3a,4,5,6,7-hexahydro-2H-azulen-1-yl]-3-methylbutyl]benzene-1,3-dicarbaldehyde | ||
| SMILES | CC1CCC(C=C2C1CCC2(C)C(CC(C)C)C3=C(C(=C(C(=C3O)C=O)O)C=O)O)C(C)(C)O | ||
| Standard InChIKey | VUKIJLQDSQXHDI-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C28H40O6/c1-15(2)11-22(23-25(32)19(13-29)24(31)20(14-30)26(23)33)28(6)10-9-18-16(3)7-8-17(12-21(18)28)27(4,5)34/h12-18,22,31-34H,7-11H2,1-6H3 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | Macrocarpal D is a HIV-RTase inhibitor. It has antibacterial activity. |
| Targets | HIV-RTase | Antifection |
| In vitro | Macrocarpals: HIV-RTase inhibitors of Eucalyptus globulus.[Reference: WebLink]Tetrahedron Letters, 1992, 33(21):2983-2986.
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| Structure Identification | Journal of the Agricultural Chemical Society of Japan, 1992, 56(10):1570-1576.Isolation and Characterization of Macrocarpals B—G Antibacterial Compounds from Eucalyptus macrocarpa.[Reference: WebLink]
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Macrocarpal D Dilution Calculator
Macrocarpal D Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.116 mL | 10.5798 mL | 21.1595 mL | 42.3191 mL | 52.8989 mL |
| 5 mM | 0.4232 mL | 2.116 mL | 4.2319 mL | 8.4638 mL | 10.5798 mL |
| 10 mM | 0.2116 mL | 1.058 mL | 2.116 mL | 4.2319 mL | 5.2899 mL |
| 50 mM | 0.0423 mL | 0.2116 mL | 0.4232 mL | 0.8464 mL | 1.058 mL |
| 100 mM | 0.0212 mL | 0.1058 mL | 0.2116 mL | 0.4232 mL | 0.529 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Eucalypglobulusals A-J, Formyl-Phloroglucinol-Terpene Meroterpenoids from Eucalyptus globulus Fruits.[Pubmed:30543429]
J Nat Prod. 2018 Dec 13.
Ten new formyl-phloroglucinol-terpene meroterpenoids, eucalypglobulusals A-J (1-10), and ten known analogues were isolated from Eucalyptus globulus fruits. The structures of 1-10 were determined by spectroscopic analysis, while their absolute configurations were established using calculated and experimental electronic circular dichroism (ECD) spectra. Eucalypglobulusal A was assigned as a new formyl-phloroglucinol-terpene meroterpenoid with a rearranged sesquiterpene skeleton, and an aldol condensation between C-3 and C-5 of the germacrene C moiety was proposed to be a key step in its putative biosynthetic pathway. Eucalypglobulusal F exhibited cytotoxicity against the human acute lymphoblastic cell line (CCRF-CEM) with an IC50 value of 3.3 muM, while eucalypglobulusal A, eucarobustol C, macrocarpal A, macrocarpal B, and Macrocarpal D exhibited DNA topoisomerase I (Top1) inhibition. The compounds eucalypglobulusal A and macrocarpal A act as Top1 catalytic inhibitors and delay Top1 poison-mediated DNA double-strand damage.
