LPA2 antagonist 1CAS# 1017606-66-4 |
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Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
| Cas No. | 1017606-66-4 | SDF | Download SDF |
| PubChem ID | 24882686 | Appearance | Powder |
| Formula | C20H23Cl2N5O2S2 | M.Wt | 500.46 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Solubility | DMSO : ≥ 100 mg/mL (199.82 mM) DMF : ≥ 100 mg/mL (199.82 mM) *"≥" means soluble, but saturation unknown. | ||
| Chemical Name | N-[(2S)-1-[4-(3,4-dichlorophenyl)sulfonylpiperazin-1-yl]propan-2-yl]-7-methylthieno[3,2-d]pyrimidin-4-amine | ||
| SMILES | CC1=CSC2=C1N=CN=C2NC(C)CN3CCN(CC3)S(=O)(=O)C4=CC(=C(C=C4)Cl)Cl | ||
| Standard InChIKey | BPRNMVDTWIHULJ-AWEZNQCLSA-N | ||
| Standard InChI | InChI=1S/C20H23Cl2N5O2S2/c1-13-11-30-19-18(13)23-12-24-20(19)25-14(2)10-26-5-7-27(8-6-26)31(28,29)15-3-4-16(21)17(22)9-15/h3-4,9,11-12,14H,5-8,10H2,1-2H3,(H,23,24,25)/t14-/m0/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
LPA2 antagonist 1 Dilution Calculator
LPA2 antagonist 1 Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 1.9982 mL | 9.9908 mL | 19.9816 mL | 39.9632 mL | 49.954 mL |
| 5 mM | 0.3996 mL | 1.9982 mL | 3.9963 mL | 7.9926 mL | 9.9908 mL |
| 10 mM | 0.1998 mL | 0.9991 mL | 1.9982 mL | 3.9963 mL | 4.9954 mL |
| 50 mM | 0.04 mL | 0.1998 mL | 0.3996 mL | 0.7993 mL | 0.9991 mL |
| 100 mM | 0.02 mL | 0.0999 mL | 0.1998 mL | 0.3996 mL | 0.4995 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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LPA2 antagonist 1 is a LPA2 antagonist with an IC50 of 17 nM.
In Vitro:LPA2 antagonist 1 inhibits the phosphorylation of Erk induced by LPA in a concentration dependent manner. LPA2 antagonist 1 inhibits HCT-116 colon cancer cell proliferation caused by LPA in a doses dependent manner[1].
References:
[1]. Beck HP, et al. Discovery of potent LPA2 (EDG4) antagonists as potential anticancer agents. Bioorg Med Chem Lett. 2008 Feb 1;18(3):1037-41.
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LPA2 antagonist 1 is a LPA2 antagonist with an IC50 of 17 nM.
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