Home >> Research Area >>Neuroscience>>AChR>> Hexamethonium Bromide

Hexamethonium Bromide

Nicotinic receptor blocker CAS# 55-97-0

Hexamethonium Bromide

Catalog No. BCC4561----Order now to get a substantial discount!

Product Name & Size Price Stock
Hexamethonium Bromide:50mg $67.00 In stock
Hexamethonium Bromide:100mg $114.00 In stock
Hexamethonium Bromide:250mg $268.00 In stock
Hexamethonium Bromide:500mg $469.00 In stock
Related Products

Quality Control of Hexamethonium Bromide

Number of papers citing our products

Chemical structure

Hexamethonium Bromide

3D structure

Chemical Properties of Hexamethonium Bromide

Cas No. 55-97-0 SDF Download SDF
PubChem ID 5938 Appearance Powder
Formula C12H30Br2N2 M.Wt 362.19
Type of Compound N/A Storage Desiccate at -20°C
Solubility Soluble to 100 mM in water and to 50 mM in DMSO
Chemical Name trimethyl-[6-(trimethylazaniumyl)hexyl]azanium;dibromide
SMILES C[N+](C)(C)CCCCCC[N+](C)(C)C.[Br-].[Br-]
Standard InChIKey FAPSXSAPXXJTOU-UHFFFAOYSA-L
Standard InChI InChI=1S/C12H30N2.2BrH/c1-13(2,3)11-9-7-8-10-12-14(4,5)6;;/h7-12H2,1-6H3;2*1H/q+2;;/p-2
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Biological Activity of Hexamethonium Bromide

DescriptionNicotinic receptor (nAChR) blocker at autonomic ganglia; prevents nicotine-mediated inhibition of apoptosis. Induces changes in neuronal activity similar to the influences of glutamate in vitro. Inhibits nicotine-mediated induction of XIAP and survivin.

Hexamethonium Bromide Dilution Calculator

Concentration (start)
x
Volume (start)
=
Concentration (final)
x
Volume (final)
 
 
 
C1
V1
C2
V2

calculate

Hexamethonium Bromide Molarity Calculator

Mass
=
Concentration
x
Volume
x
MW*
 
 
 
g/mol

calculate

Preparing Stock Solutions of Hexamethonium Bromide

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.761 mL 13.8049 mL 27.6098 mL 55.2196 mL 69.0245 mL
5 mM 0.5522 mL 2.761 mL 5.522 mL 11.0439 mL 13.8049 mL
10 mM 0.2761 mL 1.3805 mL 2.761 mL 5.522 mL 6.9025 mL
50 mM 0.0552 mL 0.2761 mL 0.5522 mL 1.1044 mL 1.3805 mL
100 mM 0.0276 mL 0.138 mL 0.2761 mL 0.5522 mL 0.6902 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

Organizitions Citing Our Products recently

 
 
 

Calcutta University

University of Minnesota

University of Maryland School of Medicine

University of Illinois at Chicago

The Ohio State University

University of Zurich

Harvard University

Colorado State University

Auburn University

Yale University

Worcester Polytechnic Institute

Washington State University

Stanford University

University of Leipzig

Universidade da Beira Interior

The Institute of Cancer Research

Heidelberg University

University of Amsterdam

University of Auckland
TsingHua University
TsingHua University
The University of Michigan
The University of Michigan
Miami University
Miami University
DRURY University
DRURY University
Jilin University
Jilin University
Fudan University
Fudan University
Wuhan University
Wuhan University
Sun Yat-sen University
Sun Yat-sen University
Universite de Paris
Universite de Paris
Deemed University
Deemed University
Auckland University
Auckland University
The University of Tokyo
The University of Tokyo
Korea University
Korea University

Background on Hexamethonium Bromide

Hexamethonium Bromide is a selective antagonist of neuronal-type nicotinic AChR in ganglia.

Featured Products
New Products
 

References on Hexamethonium Bromide

The effect of inhaled hexamethonium bromide and atropine sulphate on airway responsiveness to histamine.[Pubmed:2861223]

J Allergy Clin Immunol. 1985 Jul;76(1):97-103.

The degree of protection against inhaled histamine achieved by inhalation of the ganglion blocker Hexamethonium Bromide plus placebo, hexamethonium plus atropine sulphate, and placebo plus placebo was examined in six atopic subjects, four of whom had current asthma. Hexamethonium was administered until there was systemic evidence of ganglionic blockade with a postural drop in blood pressure of 31 +/- 7.5 mm Hg (mean +/- SD) (p = 0.01) and an increase in heart rate of 30 +/- 3.1 bpm (mean +/- SD) (p = 0.01). Atropine was inhaled in a dose (18 mg nebulized during tidal breathing) known to produce systemic inhibition of cardiac and salivary cholinergic (muscarinic) receptors. The airway effects were measured by FEV1. Hexamethonium caused bronchoconstriction in all four subjects with asthma, which was reversed by atropine. The mean provocation concentration of histamine to provoke a 20% fall in FEV1 was 2.97 mg/ml after premedication with placebo, it was not different at 2.84 mg/ml after hexamethonium alone, and it increased slightly to 5.31 mg/ml after both hexamethonium and atropine (p = 0.06). The results suggest that the main effect of inhaled histamine is not by reflex bronchoconstriction but rather through stimulation of H1-receptors on airway smooth muscle. Therefore, histamine hyperresponsiveness in asthma is not primarily caused by a defect in the parasympathetic nervous supply to the airway.

The nicotinic receptor blocker hexamethonium alters neuronal responses to glutamate in the medial septal area of the brain of the ground squirrel in vitro.[Pubmed:18264777]

Neurosci Behav Physiol. 2008 Mar;38(3):297-307.

Despite extensive interest in studies of the medial septal area, the nature of the interactions of its various neurochemical systems remains largely unclear. The aim of the present work was to clarify the role of nicotinic receptors in mediating the interaction of the glutamatergic and cholinergic systems in this structure. Extracellular recording of neuron activity in living slices of ground squirrel brain was used to study the influences of L-glutamate (1 microM) during application of the nicotinic receptor blocker hexamethonium (1 mM). The responses of septal neurons to glutamate depended on the type of their initial activity and the presence of pacemaker properties. This study is the first to show that glutamate increases the frequency of volleys in rhythmic neurons in the septum. Hexamethonium induced changes in neuron activity similar to the influences of glutamate. After prior application of hexamethonium, the responses of neurons to glutamate changed: activatory responses were masked and inhibitory responses were enhanced. Cholinergic modulation of the responses of septal neurons to glutamate were shown to occur, as did modulation of the strength of the oscillatory properties of the septal network by nicotinic receptors.

Description

Hexamethonium Dibromide is a selective antagonist of neuronal-type nicotinic AChR in ganglia.

Keywords:

Hexamethonium Bromide,55-97-0,Natural Products,AChR, buy Hexamethonium Bromide , Hexamethonium Bromide supplier , purchase Hexamethonium Bromide , Hexamethonium Bromide cost , Hexamethonium Bromide manufacturer , order Hexamethonium Bromide , high purity Hexamethonium Bromide

Online Inquiry for:

      Fill out the information below

      • Size:Qty: - +

      * Required Fields

                                      Result: