Giganteone ACAS# 460337-13-7 |
Quality Control & MSDS
Number of papers citing our products
Chemical structure
| Cas No. | 460337-13-7 | SDF | Download SDF |
| PubChem ID | N/A | Appearance | Oil |
| Formula | C42H50O10 | M.Wt | 714.9 |
| Type of Compound | Phenols | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
Giganteone A Dilution Calculator
Giganteone A Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 1.3988 mL | 6.994 mL | 13.988 mL | 27.9759 mL | 34.9699 mL |
| 5 mM | 0.2798 mL | 1.3988 mL | 2.7976 mL | 5.5952 mL | 6.994 mL |
| 10 mM | 0.1399 mL | 0.6994 mL | 1.3988 mL | 2.7976 mL | 3.497 mL |
| 50 mM | 0.028 mL | 0.1399 mL | 0.2798 mL | 0.5595 mL | 0.6994 mL |
| 100 mM | 0.014 mL | 0.0699 mL | 0.1399 mL | 0.2798 mL | 0.3497 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Giganteone A and malabaricone C as potential pharmacotherapy for diabetes mellitus.[Pubmed:33593208]
Nat Prod Res. 2022 Mar;36(6):1581-1586.
The use of antidiabetic agents which control glycemic levels in the blood and simultaneously inhibit oxidative stress is an important strategy in the prevention of Diabetes Mellitus and its complications. In our previous study, malabaricone C (3) and its dimer, Giganteone A (5) exhibited significant DPPH free radical scavenging activities which were lower than the activity of the positive control, ascorbic acid. These compounds were evaluated for their alpha-glucosidase inhibitory activities at different concentrations (0.02-2.5 mM) in the present study. Compounds 3 (IC50 59.61 microM) and 5 (IC50 39.52 microM) were identified as active alpha-glucosidase inhibitors, each respectively being 24 and 37 folds more potent than the standard inhibitor, acarbose. Based on the molecular docking studies, compounds 3 and 5 docked into the active site of the alpha-glucosidase enzyme, forming mainly hydrogen bonds in the active site.
Quorum Sensing Inhibitory Activity of Giganteone A from Myristica cinnamomea King against Escherichia coli Biosensors.[Pubmed:27102164]
Molecules. 2016 Mar 21;21(3):391.
Malabaricones A-C (1-3) and Giganteone A (4) were isolated from the bark of Myristica cinnamomea King. Their structures were elucidated and characterized by means of NMR and MS spectral analyses. These isolates were evaluated for their anti-quorum sensing activity using quorum sensing biosensors, namely Escherichia coli [pSB401] and Escherichia coli [pSB1075], whereby the potential of Giganteone A (4) as a suitable anti-quorum sensing agent was demonstrated.
Acylphenols from Myristica crassa as new acetylcholinesterase inhibitors.[Pubmed:18671198]
Planta Med. 2008 Oct;74(12):1457-62.
A significant acetylcholinesterase inhibitory activity was observed for the ethyl acetate and methanol extracts from the leaves and the fruits of MYRISTICA CRASSA. Three new dimeric acylphenols, giganteone C ( 5), maingayones B and C ( 6 and 7) were isolated together with the known malabaricones B and C ( 2 and 3) and Giganteone A ( 4). Compounds 2 and 3 possess significant inhibitory activity on acetylcholinesterase. LC/MS study was particularly useful to discriminate structures of compounds 6 and 7.
