GelsevirineCAS# 38990-03-3 |
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
| Cas No. | 38990-03-3 | SDF | Download SDF |
| PubChem ID | 5491636 | Appearance | Powder |
| Formula | C21H24N2O3 | M.Wt | 352.4 |
| Type of Compound | Alkaloids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| SMILES | CN1CC2(C3CC4C5(C2C1C3CO4)C6=CC=CC=C6N(C5=O)OC)C=C | ||
| Standard InChIKey | SSSCMFCWHWCCEH-LGUFPRDESA-N | ||
| Standard InChI | InChI=1S/C21H24N2O3/c1-4-20-11-22(2)17-12-10-26-16(9-14(12)20)21(18(17)20)13-7-5-6-8-15(13)23(25-3)19(21)24/h4-8,12,14,16-18H,1,9-11H2,2-3H3/t12?,14-,16+,17-,18+,20?,21+/m1/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
||
| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
||
| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | 1. Gelsevirine has anxiolytic activity, may be via the agonist action of glycine receptor in the brain. 2. Gelsevirine can significantly inhibit the proliferation of human carcinoma cell line SW480 and MGC80-3 in a dose-dependent manner, the 50% inhibiting concentration(IC50)of gelsevirine on SW480 cells and MGC80-3 cells are 1.41±0.06 mM and 1.22±0.11 mM respectively. |
Gelsevirine Dilution Calculator
Gelsevirine Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.8377 mL | 14.1884 mL | 28.3768 mL | 56.7537 mL | 70.9421 mL |
| 5 mM | 0.5675 mL | 2.8377 mL | 5.6754 mL | 11.3507 mL | 14.1884 mL |
| 10 mM | 0.2838 mL | 1.4188 mL | 2.8377 mL | 5.6754 mL | 7.0942 mL |
| 50 mM | 0.0568 mL | 0.2838 mL | 0.5675 mL | 1.1351 mL | 1.4188 mL |
| 100 mM | 0.0284 mL | 0.1419 mL | 0.2838 mL | 0.5675 mL | 0.7094 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
Calcutta University
University of Minnesota
University of Maryland School of Medicine
University of Illinois at Chicago
The Ohio State University
University of Zurich
Harvard University
Colorado State University
Auburn University
Yale University
Worcester Polytechnic Institute
Washington State University
Stanford University
University of Leipzig
Universidade da Beira Interior
The Institute of Cancer Research
Heidelberg University
University of Amsterdam
University of Auckland
TsingHua University
The University of Michigan
Miami University
DRURY University
Jilin University
Fudan University
Wuhan University
Sun Yat-sen University
Universite de Paris
Deemed University
Auckland University
The University of Tokyo
Korea University
- (S)-CPW 399
Catalog No.:BCC7106
CAS No.:389888-02-2
- α-Tocopherol phosphate
Catalog No.:BCC5420
CAS No.:38976-17-9
- Ophiopogonin B
Catalog No.:BCN5378
CAS No.:38971-41-4
- 2'-O-Methylperlatolic acid
Catalog No.:BCN5442
CAS No.:38968-07-9
- Eriodictyol-7-O-glucoside
Catalog No.:BCN4743
CAS No.:38965-51-4
- N-Acetylnorloline
Catalog No.:BCN2005
CAS No.:38964-35-1
- Raspberry ketone glucoside
Catalog No.:BCC8244
CAS No.:38963-94-9
- Prasugrel Maleic acid
Catalog No.:BCC4292
CAS No.:389574-20-3
- Prasugrel hydrochloride
Catalog No.:BCC4291
CAS No.:389574-19-0
- Piperlotine A
Catalog No.:BCN6481
CAS No.:389572-70-7
- Icariside D2
Catalog No.:BCN7217
CAS No.:38954-02-8
- Isovitexin
Catalog No.:BCN5441
CAS No.:38953-85-4
- 2-Acetyl-6-methoxynaphthalene
Catalog No.:BCC8514
CAS No.:3900-45-6
- Albiflorin
Catalog No.:BCN1264
CAS No.:39011-90-0
- Oxypaeoniflorin
Catalog No.:BCN6346
CAS No.:39011-91-1
- Nuezhenide
Catalog No.:BCN5444
CAS No.:39011-92-2
- Iristectorigenin A
Catalog No.:BCN8393
CAS No.:86849-77-6
- Epimedoside A
Catalog No.:BCN2886
CAS No.:39012-04-9
- Picroside II
Catalog No.:BCN6323
CAS No.:39012-20-9
- (E)-2-(3-(3,4-dimethoxyphenyl)acryloyloxy)succinic acid
Catalog No.:BCN8545
CAS No.:39015-77-5
- Wilsonine
Catalog No.:BCN5445
CAS No.:39024-12-9
- 3-Epiwilsonine
Catalog No.:BCN5446
CAS No.:39024-15-2
- Z-Guggulsterone
Catalog No.:BCC7712
CAS No.:39025-23-5
- Guggulsterone E
Catalog No.:BCC8181
CAS No.:39025-24-6
The active alkaloids of Gelsemium elegans Benth. are potent anxiolytics.[Pubmed:23052566]
Psychopharmacology (Berl). 2013 Feb;225(4):839-51.
RATIONALE: An increasing number of herbal products has been introduced to treat anxiety and depression. Gelsemium elegans Benth (G. elegans) is a well-known herbal plant in Asia. Four major alkaloids (gelsemine, koumine, Gelsevirine, and gelsenicine) have been isolated from G. elegans. Recently, interest has arisen to investigate the pharmaceutical potential of G. elegans alkaloids in the context of neuropsychopharmacology. OBJECTIVES: We investigated whether G. elegans alkaloids are capable of producing anxiolytic and antidepressant effects in mouse models. In particular, we examined whether the anxiolytic action of G. elegans alkaloids is due to the agonist effects of glycine receptor in the brain. METHODS: Two mouse models (elevated plus-maze and light-dark transition model) were used to examine potential anxiolytic effects. Forced swim test and tail suspension test were used to test the antidepressive action of G. elegans alkaloids. Moreover, we also explored the anxiolytic mechanisms of G. elegans alkaloids by intracerebroventricular administration of strychnine, an antagonist of glycine receptor, in the elevated plus-maze. RESULTS: Gelsemine, koumine, and Gelsevirine, but not gelsenicine, exhibited potent anxiolytic effects in the two anxiety models. None of the four G. elegans alkaloids exerted antidepressant effects in the two depression models. None of G. elegans alkaloids impaired spontaneous motor activities. The intracerebroventricular administration of strychnine significantly antagonized the anxiolytic effects of gelsemine, koumine, and Gelsevirine administrated subcutaneously. CONCLUSIONS: Gelsemine, koumine, and Gelsevirine could be developed as the treatment of anxiety-related disorders in human patients. Their anxiolytic mechanism may be involved in the agonist action of glycine receptor in the brain.
