Eupalinolide H

CAS# 1402067-83-7

Eupalinolide H

Catalog No. BCN9134----Order now to get a substantial discount!

Product Name & Size Price Stock
Eupalinolide H: 5mg $322 In Stock
Eupalinolide H: 10mg Please Inquire In Stock
Eupalinolide H: 20mg Please Inquire Please Inquire
Eupalinolide H: 50mg Please Inquire Please Inquire
Eupalinolide H: 100mg Please Inquire Please Inquire
Eupalinolide H: 200mg Please Inquire Please Inquire
Eupalinolide H: 500mg Please Inquire Please Inquire
Eupalinolide H: 1000mg Please Inquire Please Inquire

Quality Control of Eupalinolide H

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Chemical structure

Eupalinolide H

3D structure

Chemical Properties of Eupalinolide H

Cas No. 1402067-83-7 SDF Download SDF
PubChem ID 71477364 Appearance Powder
Formula C22H28O8 M.Wt 420.45
Type of Compound Sesquiterpenoids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name [(3aR,4R,6Z,9R,10Z,11aR)-9-acetyloxy-6-(hydroxymethyl)-10-methyl-3-methylidene-2-oxo-3a,4,5,8,9,11a-hexahydrocyclodeca[b]furan-4-yl] (E)-4-hydroxy-2-methylbut-2-enoate
SMILES CC1=CC2C(C(CC(=CCC1OC(=O)C)CO)OC(=O)C(=CCO)C)C(=C)C(=O)O2
Standard InChIKey INXZZSZBRLXKNT-PZXWXBCTSA-N
Standard InChI InChI=1S/C22H28O8/c1-12(7-8-23)21(26)29-19-10-16(11-24)5-6-17(28-15(4)25)13(2)9-18-20(19)14(3)22(27)30-18/h5,7,9,17-20,23-24H,3,6,8,10-11H2,1-2,4H3/b12-7+,13-9-,16-5-/t17-,18-,19-,20+/m1/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Eupalinolide H Dilution Calculator

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Eupalinolide H Molarity Calculator

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Preparing Stock Solutions of Eupalinolide H

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.3784 mL 11.892 mL 23.784 mL 47.5681 mL 59.4601 mL
5 mM 0.4757 mL 2.3784 mL 4.7568 mL 9.5136 mL 11.892 mL
10 mM 0.2378 mL 1.1892 mL 2.3784 mL 4.7568 mL 5.946 mL
50 mM 0.0476 mL 0.2378 mL 0.4757 mL 0.9514 mL 1.1892 mL
100 mM 0.0238 mL 0.1189 mL 0.2378 mL 0.4757 mL 0.5946 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Eupalinolide H

Precise discovery of a STAT3 inhibitor from Eupatorium lindleyanum and evaluation of its activity of anti-triple-negative breast cancer.[Pubmed:29086600]

Nat Prod Res. 2019 Feb;33(4):477-485.

Michael reaction acceptors (MRAs) are a class of active compounds. There is a great prospect to screen STAT3 inhibitors from Eupatorium lindleyanum, furthermore, to discover lead compounds for anti-triple-negative breast cancer (TNBC). In this study, glutathione (GSH) was employed, and a UPLC-MS screening method was developed to discover MRAs. We screened MRAs which can inhibit STAT3 using a STAT3-dependent reporter system. Six sesquiterpene lactones, including a new compound Eupalinolide O (1), together with five known compounds, Eupalinolide I (2), Eupalinolide K (3), Eupalinolide H (4), Eupalinolide J (5) and Eupalinolide G (6) were isolated. Eupalinolide J was identified as MRA that decreased luciferase activity of STAT3. Preliminary activity assessment showed that Eupalinolide J could inhibit the viability of TNBC cell lines. We demonstrated that Eupalinolide J, which is a natural typical MRA, has a notable inhibition of STAT3 activity and a potential cytotoxic activity against TNBC cell lines.

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