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Ethyl orsellinate

CAS# 2524-37-0

Ethyl orsellinate

Catalog No. BCN4662----Order now to get a substantial discount!

Product Name & Size Price Stock
Ethyl orsellinate:5mg $30.00 In Stock
Ethyl orsellinate:10mg Please Inquire Instock
Ethyl orsellinate:20mg Please Inquire Instock
Ethyl orsellinate:50mg Please Inquire Instock

Quality Control of Ethyl orsellinate

Number of papers citing our products

Chemical structure

Ethyl orsellinate

3D structure

Chemical Properties of Ethyl orsellinate

Cas No. 2524-37-0 SDF Download SDF
PubChem ID 75653 Appearance Powder
Formula C10H12O4 M.Wt 196.20
Type of Compound Phenols Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name ethyl 2,4-dihydroxy-6-methylbenzoate
SMILES CCOC(=O)C1=C(C=C(C=C1C)O)O
Standard InChIKey UQSRXQMIXSZGLA-UHFFFAOYSA-N
Standard InChI InChI=1S/C10H12O4/c1-3-14-10(13)9-6(2)4-7(11)5-8(9)12/h4-5,11-12H,3H2,1-2H3
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Ethyl orsellinate

The herbs of Usnea diffracta

Biological Activity of Ethyl orsellinate

DescriptionEthyl orsellinate shows good inhibition of protein glycation, and urease activities.
In vitro

New antiglycation and enzyme inhibitors from Parmotrema cooperi[Reference: WebLink]

Science China Chemistry, 2011 ,54 (12) :1926-1931.

Lichens are unique individuals which have been widely used in traditional medicines. This study was focused on the bioassay-guided phytochemical investigation, and bioactivity evaluation on a lichens species, Parmotrema cooperi.
METHODS AND RESULTS:
This first bioassay-directed chemical study on P. cooperi has led to the isolation of ethyl heamatomate (1), atraric acid (2), Ethyl orsellinate (3), orsellinic acid (4), lecanoric acid (5), gyrophoric acid (6), and licanorin (7). The structures of 1–7 were mainly elucidated from spectroscopic methods including 1D, and 2D NMR spectroscopy, and mass spectrometry. These compounds were evaluated for their antiglycation, urease, α-chymotrypsin, and β-glucoronidase inhibitory activities.
CONCLUSIONS:
Few of the phenolic compounds showed significant, while most of them showed good inhibition of protein glycation, and urease activities.

Protocol of Ethyl orsellinate

Structure Identification
Zhongguo Zhong Yao Za Zhi. 2011 Aug;36(16):2233-5.

Determination of atranol, lecanorin, ethyl orsellinate and methyl orsellinate in Usnea diffracta by RP-HPLC.[Pubmed: 22097337 ]

To develop a RP-HPLC method for determining the contents of atranol, lecanorin, Ethyl orsellinate and mEthyl orsellinate in Usnea diffracta.
METHODS AND RESULTS:
A Kromasil-C18 column (4.6 mm x 250 mm, 5 microm) was used at 25 degrees C with the mobile phases of acetonitrile -1% acetic acid in a gradient manner. The flow rate was set at 1.0 mL x min(-1). The detection wavelength was 280 nm. The correlation coefficients of atranol, lecanorin, Ethyl orsellinate, and mEthyl orsellinate were higher than 0.999. Recoveries were from 102.9% to 95.30%; with RSD from 2.3% to 1.9%.
CONCLUSIONS:
The method is quick, simple and repeatable for simultaneous determination of atranol, lecanorin, Ethyl orsellinate and mEthyl orsellinate in U. diffracta.

Ethyl orsellinate Dilution Calculator

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Ethyl orsellinate Molarity Calculator

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Preparing Stock Solutions of Ethyl orsellinate

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 5.0968 mL 25.4842 mL 50.9684 mL 101.9368 mL 127.421 mL
5 mM 1.0194 mL 5.0968 mL 10.1937 mL 20.3874 mL 25.4842 mL
10 mM 0.5097 mL 2.5484 mL 5.0968 mL 10.1937 mL 12.7421 mL
50 mM 0.1019 mL 0.5097 mL 1.0194 mL 2.0387 mL 2.5484 mL
100 mM 0.051 mL 0.2548 mL 0.5097 mL 1.0194 mL 1.2742 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Ethyl orsellinate

[Determination of atranol, lecanorin, ethyl orsellinate and methyl orsellinate in Usnea diffracta by RP-HPLC].[Pubmed:22097337]

Zhongguo Zhong Yao Za Zhi. 2011 Aug;36(16):2233-5.

OBJECTIVE: To develop a RP-HPLC method for determining the contents of atranol, lecanorin, Ethyl orsellinate and mEthyl orsellinate in Usnea diffracta. METHOD: A Kromasil-C18 column (4.6 mm x 250 mm, 5 microm) was used at 25 degrees C with the mobile phases of acetonitrile -1% acetic acid in a gradient manner. The flow rate was set at 1.0 mL x min(-1). The detection wavelength was 280 nm. RESULT: The correlation coefficients of atranol, lecanorin, Ethyl orsellinate, and mEthyl orsellinate were higher than 0.999. Recoveries were from 102.9% to 95.30%; with RSD from 2.3% to 1.9%. CONCLUSION: The method is quick, simple and repeatable for simultaneous determination of atranol, lecanorin, Ethyl orsellinate and mEthyl orsellinate in U. diffracta.

[Study on the chemical constituents of two lichen plants from Meng Mountain].[Pubmed:24620693]

Zhong Yao Cai. 2013 Sep;36(9):1454-6.

OBJECTIVE: To investigate the chemical constituents of the lichen plants Parmelia tinctorum and Parmelia nimandairana collected from Meng Mountain in Shandong province. METHODS: Various chromatographic techniques were used to isolate and purify the constituents and their structures were elucidated by means of spectral evidence and physiochemical properties. RESULTS: Four compounds were isolated from Parmelia tinctorum and identified as: lecanoric acid (I), evernic acid (II), Ethyl orsellinate (III) and 3,5-dihydroxytoluene (IV). Two compounds were isolated from Parmelia nimandairana and identified as: usnic acid (V) and salazinic acid (VI). CONCLUSION: Compounds V and VI are isolated from Parmelia nimandairana for the first time.

Description

Ethyl orsellinate is a lichen metabolite and a derivative of lecanoric acid with antiproliferative and antitumour activities. Ethyl Orsellinate is against A. salina for the cytotoxic activity with an LC50 of 495 μM.

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