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Dihydropedicin

CAS# 169234-89-3

Dihydropedicin

Catalog No. BCN4692----Order now to get a substantial discount!

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Dihydropedicin:5mg Please Inquire In Stock
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Quality Control of Dihydropedicin

Number of papers citing our products

Chemical structure

Dihydropedicin

3D structure

Chemical Properties of Dihydropedicin

Cas No. 169234-89-3 SDF Download SDF
PubChem ID 10449415 Appearance Powder
Formula C18H20O6 M.Wt 332.35
Type of Compound Chalcones Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name 1-(2,5-dihydroxy-3,4,6-trimethoxyphenyl)-3-phenylpropan-1-one
SMILES COC1=C(C(=C(C(=C1C(=O)CCC2=CC=CC=C2)O)OC)OC)O
Standard InChIKey HIEHRZJVVWOTEJ-UHFFFAOYSA-N
Standard InChI InChI=1S/C18H20O6/c1-22-16-13(12(19)10-9-11-7-5-4-6-8-11)14(20)17(23-2)18(24-3)15(16)21/h4-8,20-21H,9-10H2,1-3H3
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Dihydropedicin

The herbs of Fissistigma lanuginosum

Biological Activity of Dihydropedicin

DescriptionStandard reference

Protocol of Dihydropedicin

Structure Identification
J Nat Prod. 1995 Aug;58(8):1160-6.

An antimitotic and cytotoxic chalcone from Fissistigma lanuginosum.[Pubmed: 7595585]


METHODS AND RESULTS:
Bioassay-guided fractionation of an ethyl acetate extract of Fissistigma lanuginosum led to the isolation of the known chalcone pedicin [1], which inhibited tubulin assembly into microtubules (IC50 value of 300 microM). From the same EtOAc fraction, two new condensed chalcones, fissistin [2] and isofissistin [3], which showed cytotoxicity against KB cells, were also obtained, together with the inactive Dihydropedicin [4] and 6,7-dimethoxy-5,8-dihydroxyflavone [5]. In addition, the aminoquinones 6, 8, and 9 were isolated from the alkaloid extract.
CONCLUSIONS:
These compounds were artifacts, prepared by treatment of 1, 4, and 2, respectively, with NH4OH. The structures of the new compounds were elucidated by spectral methods, especially 2D nmr.

Dihydropedicin Dilution Calculator

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Dihydropedicin Molarity Calculator

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Preparing Stock Solutions of Dihydropedicin

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.0089 mL 15.0444 mL 30.0888 mL 60.1775 mL 75.2219 mL
5 mM 0.6018 mL 3.0089 mL 6.0178 mL 12.0355 mL 15.0444 mL
10 mM 0.3009 mL 1.5044 mL 3.0089 mL 6.0178 mL 7.5222 mL
50 mM 0.0602 mL 0.3009 mL 0.6018 mL 1.2036 mL 1.5044 mL
100 mM 0.0301 mL 0.1504 mL 0.3009 mL 0.6018 mL 0.7522 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Dihydropedicin

An antimitotic and cytotoxic chalcone from Fissistigma lanuginosum.[Pubmed:7595585]

J Nat Prod. 1995 Aug;58(8):1160-6.

Bioassay-guided fractionation of an ethyl acetate extract of Fissistigma lanuginosum led to the isolation of the known chalcone pedicin [1], which inhibited tubulin assembly into microtubules (IC50 value of 300 microM). From the same EtOAc fraction, two new condensed chalcones, fissistin [2] and isofissistin [3], which showed cytotoxicity against KB cells, were also obtained, together with the inactive Dihydropedicin [4] and 6,7-dimethoxy-5,8-dihydroxyflavone [5]. In addition, the aminoquinones 6, 8, and 9 were isolated from the alkaloid extract. These compounds were artifacts, prepared by treatment of 1, 4, and 2, respectively, with NH4OH. The structures of the new compounds were elucidated by spectral methods, especially 2D nmr.

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