Darifenacin HBrCAS# 133099-07-7 |
Related Products
- Nelarabine
Catalog No.:BCC1072
CAS No.:121032-29-9
- Gemcitabine HCl
Catalog No.:BCC1076
CAS No.:122111-03-9
- Clofarabine
Catalog No.:BCC1078
CAS No.:123318-82-1
- Ifosfamide
Catalog No.:BCC1164
CAS No.:3778-73-2
- Carboplatin
Catalog No.:BCC1170
CAS No.:41575-94-4
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
| Cas No. | 133099-07-7 | SDF | Download SDF |
| PubChem ID | 444030 | Appearance | Powder |
| Formula | C28H31BrN2O2 | M.Wt | 507.48 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Solubility | DMSO : 33.33 mg/mL (65.68 mM; Need ultrasonic) H2O : < 0.1 mg/mL (insoluble) | ||
| Chemical Name | 2-[(3S)-1-[2-(2,3-dihydro-1-benzofuran-5-yl)ethyl]pyrrolidin-3-yl]-2,2-diphenylacetamide;hydrobromide | ||
| SMILES | C1CN(CC1C(C2=CC=CC=C2)(C3=CC=CC=C3)C(=O)N)CCC4=CC5=C(C=C4)OCC5.Br | ||
| Standard InChIKey | UQAVIASOPREUIT-VQIWEWKSSA-N | ||
| Standard InChI | InChI=1S/C28H30N2O2.BrH/c29-27(31)28(23-7-3-1-4-8-23,24-9-5-2-6-10-24)25-14-17-30(20-25)16-13-21-11-12-26-22(19-21)15-18-32-26;/h1-12,19,25H,13-18,20H2,(H2,29,31);1H/t25-;/m1./s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
||
| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
||
| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | Darifenacin HBr(UK88525) is a selective M3 muscarinic receptor antagonist with pKi of 8.9.
IC50 value: 8.9 (pKi) [1]
Target: M3 receptor
in vitro: Darifenacin exerts non-parallel rightward displacement of the agonist curve and also significant depression of the maximum response (+)-cis-Dioxolane produced concentration-dependent contraction of the isolated bladder of rat [1]. Darifenacin produces a concentration dependent increase in R123 (P-gp probe) accumulation in MDCK cells. Darifenacin stimulates ATPase activity in P-gp membrane in a clear concentration dependent response manner with an estimated ED50 value of 1.6?μM. Darifenacin (100 nM) shows a significantly greater permeability for darifenacin in the basolateral to apical direction resulting in an efflux ratio in BBMEC monolayers of approximately 2.6 [2].
in vivo: Darifenacin produces dose-dependent inhibition of amplitude of volume-induced bladder contractions(VIBCAMP), producing 35% inhibition at dose of 283.3 nmol/kg and maximal inhibition of approximately 50–55% [1]. Darifenacin (0.1 mg/kg i.v.) reduces bladder afferent activity in both Aδ and C fibers in female Sprague-Dawley rats, the decrease in afferent spikes in C fibers may be more pronounced than that in Aδ fibers [3]. References: | |||||
Darifenacin HBr Dilution Calculator
Darifenacin HBr Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 1.9705 mL | 9.8526 mL | 19.7052 mL | 39.4104 mL | 49.263 mL |
| 5 mM | 0.3941 mL | 1.9705 mL | 3.941 mL | 7.8821 mL | 9.8526 mL |
| 10 mM | 0.1971 mL | 0.9853 mL | 1.9705 mL | 3.941 mL | 4.9263 mL |
| 50 mM | 0.0394 mL | 0.1971 mL | 0.3941 mL | 0.7882 mL | 0.9853 mL |
| 100 mM | 0.0197 mL | 0.0985 mL | 0.1971 mL | 0.3941 mL | 0.4926 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
Calcutta University
University of Minnesota
University of Maryland School of Medicine
University of Illinois at Chicago
The Ohio State University
University of Zurich
Harvard University
Colorado State University
Auburn University
Yale University
Worcester Polytechnic Institute
Washington State University
Stanford University
University of Leipzig
Universidade da Beira Interior
The Institute of Cancer Research
Heidelberg University
University of Amsterdam
University of Auckland
TsingHua University
The University of Michigan
Miami University
DRURY University
Jilin University
Fudan University
Wuhan University
Sun Yat-sen University
Universite de Paris
Deemed University
Auckland University
The University of Tokyo
Korea University
Darifenacin HBr(UK88525) is a selective M3 muscarinic receptor antagonist with pKi of 8.9.
Featured Products
- Darifenacin
Catalog No.:BCC1516
CAS No.:133099-04-4
- 3PO
Catalog No.:BCC5616
CAS No.:13309-08-5
- Crassifoline methine
Catalog No.:BCN1793
CAS No.:133084-00-1
- Fmoc-D-Lys(Boc)-OPfp
Catalog No.:BCC3527
CAS No.:133083-36-0
- BIM 23052
Catalog No.:BCC5945
CAS No.:133073-82-2
- ZD 7288
Catalog No.:BCC6884
CAS No.:133059-99-1
- Go 6983
Catalog No.:BCC3705
CAS No.:133053-19-7
- GF 109203X
Catalog No.:BCC3704
CAS No.:133052-90-1
- LY 225910
Catalog No.:BCC6891
CAS No.:133040-77-4
- Ethacrynic acid - d5
Catalog No.:BCC7987
CAS No.:1330052-59-9
- (+)-SK&F 10047 hydrochloride
Catalog No.:BCC6928
CAS No.:133005-41-1
- 13-Epijhanol
Catalog No.:BCN4713
CAS No.:133005-15-9
New Products
- Flutamide
Catalog No.:BCC4364
CAS No.:13311-84-7
- Epimedin B1
Catalog No.:BCN8199
CAS No.:133137-58-3
- GR 73632
Catalog No.:BCC5801
CAS No.:133156-06-6
- Oxypeucedan hydrate
Catalog No.:BCN8372
CAS No.:133164-11-1
- Fmoc-Cit-OH
Catalog No.:BCC3180
CAS No.:133174-15-9
- Fmoc-Thr(Trt)-OH
Catalog No.:BCC3554
CAS No.:133180-01-5
- PI3k-delta inhibitor 1
Catalog No.:BCC1861
CAS No.:1332075-63-4
- AM 92016 hydrochloride
Catalog No.:BCC6825
CAS No.:133229-11-5
- Heliangin
Catalog No.:BCN6487
CAS No.:13323-48-3
- 4-O-Methylbutein
Catalog No.:BCN6677
CAS No.:13323-67-6
- GSK2194069
Catalog No.:BCC8053
CAS No.:1332331-08-4
- KPT-185
Catalog No.:BCC4444
CAS No.:1333151-73-7
Darifenacin hydrobromide (UK-88525 hydrobromide) is a selective M3 muscarinic receptor antagonist with pKi of 8.9.
Darifenacin HBr,133099-07-7,Natural Products,Muscarinic Receptor, buy Darifenacin HBr , Darifenacin HBr supplier , purchase Darifenacin HBr , Darifenacin HBr cost , Darifenacin HBr manufacturer , order Darifenacin HBr , high purity Darifenacin HBr
