Cyclo(Pro-Pro)CAS# 6708-06-1 |
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
| Cas No. | 6708-06-1 | SDF | Download SDF |
| PubChem ID | 529063 | Appearance | Powder |
| Formula | C10H14N2O2 | M.Wt | 194.23 |
| Type of Compound | Miscellaneous | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | 1,2,3,5a,6,7,8,10a-octahydrodipyrrolo[1,2-c:1',2'-f]pyrazine-5,10-dione | ||
| SMILES | C1CC2C(=O)N3CCCC3C(=O)N2C1 | ||
| Standard InChIKey | BKASXWPLSXFART-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C10H14N2O2/c13-9-7-3-1-5-11(7)10(14)8-4-2-6-12(8)9/h7-8H,1-6H2 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
||
| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
||
| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | Cyclo(Pro-Pro) tasted bitter.Verpacamides A-D, a sequence of C11N5 diketopiperazines relating cyclo(Pro-Pro) to cyclo(Pro-Arg), from the marine sponge Axinella vaceleti is possible biogenetic precursors of pyrrole-2-aminoimidazole alkaloids. |
| Structure Identification | Anal Bioanal Chem. 2014 Apr;406(9-10):2433-44.Quantification of cyclic dipeptides from cultures of Lactobacillus brevis R2Δ by HRGC/MS using stable isotope dilution assay.[Pubmed: 24477717 ]Lactic acid bacteria (LAB) play an important role as natural preservatives in fermented food and beverage systems, reducing the application of chemical additives. Thus, investigating their antifungal compounds, such as cyclic dipeptides, has gained prominence. Previous research has primarily focussed on isolation of these compounds. However, their precise quantification will provide further information regarding their antifungal performance in a complex system. Org .Lett., 2006, 8(11):2421-4.Verpacamides A-D, a sequence of C11N5 diketopiperazines relating cyclo(Pro-Pro) to cyclo(Pro-Arg), from the marine sponge Axinella vaceleti: possible biogenetic precursors of pyrrole-2-aminoimidazole alkaloids.[Pubmed: 16706541 ]Four C(11)N(5) diketopiperazine metabolites named verpacamides A (6), B (7), C (8), and D (9) consisting of a proline-arginine dipeptide skeleton have been isolated from the marine sponge Axinella vaceleti. Verpacamides A-D are a sequence of metabolites showing the transformation of proline and arginine into the oxidized guanidinyl-Cyclo(Pro-Pro) 8 and 9. Compounds 6-9 are structurally and chemically related to C(11)N(5) pyrrole-2-aminoimidazole metabolites also isolated from the Axinellidae and Agelasidae families of sponges and exemplified by dispacamide A (4) and dibromophakellin (10). |
Cyclo(Pro-Pro) Dilution Calculator
Cyclo(Pro-Pro) Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 5.1485 mL | 25.7427 mL | 51.4854 mL | 102.9707 mL | 128.7134 mL |
| 5 mM | 1.0297 mL | 5.1485 mL | 10.2971 mL | 20.5941 mL | 25.7427 mL |
| 10 mM | 0.5149 mL | 2.5743 mL | 5.1485 mL | 10.2971 mL | 12.8713 mL |
| 50 mM | 0.103 mL | 0.5149 mL | 1.0297 mL | 2.0594 mL | 2.5743 mL |
| 100 mM | 0.0515 mL | 0.2574 mL | 0.5149 mL | 1.0297 mL | 1.2871 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
Calcutta University
University of Minnesota
University of Maryland School of Medicine
University of Illinois at Chicago
The Ohio State University
University of Zurich
Harvard University
Colorado State University
Auburn University
Yale University
Worcester Polytechnic Institute
Washington State University
Stanford University
University of Leipzig
Universidade da Beira Interior
The Institute of Cancer Research
Heidelberg University
University of Amsterdam
University of Auckland
TsingHua University
The University of Michigan
Miami University
DRURY University
Jilin University
Fudan University
Wuhan University
Sun Yat-sen University
Universite de Paris
Deemed University
Auckland University
The University of Tokyo
Korea University
- Datumetine
Catalog No.:BCN1930
CAS No.:67078-20-0
- Trichophydine
Catalog No.:BCN1781
CAS No.:67031-54-3
- Pepluanin A
Catalog No.:BCN4221
CAS No.:670257-89-3
- Ohchinin acetate
Catalog No.:BCN4220
CAS No.:67023-81-8
- Ohchinin
Catalog No.:BCN4601
CAS No.:67023-80-7
- Crenolanib (CP-868596)
Catalog No.:BCC3671
CAS No.:670220-88-9
- 3,4-Dihydroxy-2-methoxyxanthone
Catalog No.:BCN7631
CAS No.:6702-55-2
- Methyl isovanillate
Catalog No.:BCN7960
CAS No.:6702-50-7
- Anthriscusin
Catalog No.:BCN3533
CAS No.:67008-16-6
- Gliotoxin
Catalog No.:BCN3894
CAS No.:67-99-2
- Vitamin D3
Catalog No.:BCN2186
CAS No.:67-97-0
- Dicyclomine HCl
Catalog No.:BCC3762
CAS No.:67-92-5
- Tubotaiwine
Catalog No.:BCN4016
CAS No.:6711-69-9
- Yamataimine
Catalog No.:BCN2064
CAS No.:67113-69-3
- Moronic acid
Catalog No.:BCN4222
CAS No.:6713-27-5
- (±)-U-50488 hydrochloride
Catalog No.:BCC6665
CAS No.:67197-96-0
- H-HoSer-OH
Catalog No.:BCC3247
CAS No.:672-15-1
- SMER 3
Catalog No.:BCC6152
CAS No.:67200-34-4
- 2'-O-Coumaroyljuglanin
Catalog No.:BCN6559
CAS No.:67214-05-5
- 5'-O-Dimethoxytrityl-N-benzoyl-desoxycytidine
Catalog No.:BCC8750
CAS No.:67219-55-0
- Fenoldopam
Catalog No.:BCC4462
CAS No.:67227-56-9
- 10(14)-Cadinene-4,5-diol
Catalog No.:BCN4223
CAS No.:672336-50-4
- Boc-MLF
Catalog No.:BCC6061
CAS No.:67247-12-5
- Cabraleadiol
Catalog No.:BCN4224
CAS No.:67253-01-4
Quantification of cyclic dipeptides from cultures of Lactobacillus brevis R2Delta by HRGC/MS using stable isotope dilution assay.[Pubmed:24477717]
Anal Bioanal Chem. 2014 Apr;406(9-10):2433-44.
Lactic acid bacteria (LAB) play an important role as natural preservatives in fermented food and beverage systems, reducing the application of chemical additives. Thus, investigating their antifungal compounds, such as cyclic dipeptides, has gained prominence. Previous research has primarily focussed on isolation of these compounds. However, their precise quantification will provide further information regarding their antifungal performance in a complex system. To address this, deuterated labelled standards of the cyclic dipeptides cyclo(Leu-Pro), Cyclo(Pro-Pro), cyclo(Met-Pro) and cyclo(Phe-Pro) were synthesized, and stable isotope dilution assays were developed, enabling an accurate quantification of cyclo(Leu-Pro), Cyclo(Pro-Pro), cyclo(Met-Pro) and cyclo(Phe-Pro) in MRS-broth and wort. Quantitative results showed that, in the Lactobacillus brevis R2Delta fermented MRS-broth, the concentrations of cyclo(Leu-Pro), Cyclo(Pro-Pro) and cyclo(Phe-Pro) were significantly higher (P < 0.05), than in wort for cyclo (Leu-Pro) when compared with their controls. This indicates that the formation of these three cyclic dipeptides is related to L. brevis R2Delta metabolism. Furthermore, this represents the first report of cyclic dipeptides quantification using stable isotope dilution assays in LAB cultures both in vitro and in a food system.
Verpacamides A-D, a sequence of C11N5 diketopiperazines relating cyclo(Pro-Pro) to cyclo(Pro-Arg), from the marine sponge Axinella vaceleti: possible biogenetic precursors of pyrrole-2-aminoimidazole alkaloids.[Pubmed:16706541]
Org Lett. 2006 May 25;8(11):2421-4.
[reaction: see text] Four C(11)N(5) diketopiperazine metabolites named verpacamides A (6), B (7), C (8), and D (9) consisting of a proline-arginine dipeptide skeleton have been isolated from the marine sponge Axinella vaceleti. Verpacamides A-D are a sequence of metabolites showing the transformation of proline and arginine into the oxidized guanidinyl-Cyclo(Pro-Pro) 8 and 9. Compounds 6-9 are structurally and chemically related to C(11)N(5) pyrrole-2-aminoimidazole metabolites also isolated from the Axinellidae and Agelasidae families of sponges and exemplified by dispacamide A (4) and dibromophakellin (10).
