CorynoxidineCAS# 57906-85-1 |
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| Cas No. | 57906-85-1 | SDF | Download SDF |
| PubChem ID | 21589010 | Appearance | Powder |
| Formula | C21H25NO5 | M.Wt | 371.4 |
| Type of Compound | Alkaloids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | (7S,13aS)-2,3,9,10-tetramethoxy-7-oxido-6,8,13,13a-tetrahydro-5H-isoquinolino[2,1-b]isoquinolin-7-ium | ||
| SMILES | COC1=C(C2=C(CC3C4=CC(=C(C=C4CC[N+]3(C2)[O-])OC)OC)C=C1)OC | ||
| Standard InChIKey | QYEMUDHNCZHUKC-JTSKRJEESA-N | ||
| Standard InChI | InChI=1S/C21H25NO5/c1-24-18-6-5-13-9-17-15-11-20(26-3)19(25-2)10-14(15)7-8-22(17,23)12-16(13)21(18)27-4/h5-6,10-11,17H,7-9,12H2,1-4H3/t17-,22-/m0/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
The roots of Stephania epigaea.
| Description | 1. Corynoxidine exhibits antibacterial activities against Staphylococcus aureus and methicillin-resistant S. aureus strains. 2. Corynoxidine inhibits acetylcholinesterase activity in a dose-dependent manner, and the IC50 value of 89.0 microM. |
| Targets | Antifection | AChR |
Corynoxidine Dilution Calculator
Corynoxidine Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.6925 mL | 13.4626 mL | 26.9251 mL | 53.8503 mL | 67.3129 mL |
| 5 mM | 0.5385 mL | 2.6925 mL | 5.385 mL | 10.7701 mL | 13.4626 mL |
| 10 mM | 0.2693 mL | 1.3463 mL | 2.6925 mL | 5.385 mL | 6.7313 mL |
| 50 mM | 0.0539 mL | 0.2693 mL | 0.5385 mL | 1.077 mL | 1.3463 mL |
| 100 mM | 0.0269 mL | 0.1346 mL | 0.2693 mL | 0.5385 mL | 0.6731 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Acetylcholinesterase inhibitors from the aerial parts of Corydalis speciosa.[Pubmed:15595415]
Arch Pharm Res. 2004 Nov;27(11):1127-31.
In a bioassay-guided search for acetylcholinesterase inhibitors from Korean natural resources, four isoquinoline alkaloids, Corynoxidine (1), protopine (2), palmatine (3), and berberine (4) have been isolated from the methanolic extract of the aerial parts of Corydalis speciosa. Structures of these compounds were elucidated on the basis of spectroscopic techniques. These compounds inhibited acetylcholinesterase activity in a dose-dependent manner, and the IC50 values of compounds 1-4 were 89.0, 16.1, 5.8, and 3.3 microM, respectively.
A new antibacterial denitroaristolochic acid from the tubers of Stephania succifera.[Pubmed:23418880]
J Asian Nat Prod Res. 2013;15(3):315-8.
A new denitroaristolochic acid, demethylaristofolin C (1), together with six known alkaloids, crebanine N-oxide (2), (-)-sukhodianine-beta-N-oxide (3), palmatine (4), corydalmine (5), dehydrocorydalmine (6), and Corynoxidine (7), was isolated from the tubers of Stephania succifera. The structure of demethylaristofolin C was elucidated by spectroscopic techniques (UV, IR, 1D, and 2D NMR) and HR-ESI-MS analyses. These compounds exhibited antibacterial activities against Staphylococcus aureus and methicillin-resistant S. aureus strains in different degrees.
(-)-Corynoxidine is an acetylcholinesterase inhibitor with an IC50 value of 89.0 μM, isolated from the aerial parts of Corydalis speciosa. (-)-Corynoxidine exhibits antibacterial activities against Staphylococcus aureus and methicillin-resistant S. aureus strains in different degrees.
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