(+)-CorynolineCAS# 18797-79-0 |
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
| Cas No. | 18797-79-0 | SDF | Download SDF |
| PubChem ID | 177014 | Appearance | Light yellow powder |
| Formula | C21H21NO5 | M.Wt | 367.40 |
| Type of Compound | Alkaloids | Storage | Desiccate at -20°C |
| Synonyms | 13-Methylchelidonine | ||
| Solubility | Soluble in chloroform; slightly soluble in methan | ||
| SMILES | CC12C(CC3=CC4=C(C=C3C1N(CC5=C2C=CC6=C5OCO6)C)OCO4)O | ||
| Standard InChIKey | IQUGPRHKZNCHGC-TYPHKJRUSA-N | ||
| Standard InChI | InChI=1S/C21H21NO5/c1-21-14-3-4-15-19(27-10-24-15)13(14)8-22(2)20(21)12-7-17-16(25-9-26-17)5-11(12)6-18(21)23/h3-5,7,18,20,23H,6,8-10H2,1-2H3/t18-,20+,21-/m0/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
||
| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
||
| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | Corynoline is a reversible and noncompetitive inhibitor of acetylcholinesterase(AChE) with the IC50 value of 30.6 microM, which exhibits the potent anti-inflammatory and/or immunosuppressive activity, the potent inhibitory activity of corynoline for the ICAM-1/LFA-1 adhesion and would be important on developing the clinically usable drugs for the inflammatory diseases. |
| Targets | AChE |
| In vitro | Cell adhesion inhibitory activity of (d)-corynoline, a hexahydrobenzo[c]phenanthridine-type alkaloid, and its structure-activity relationship, studied by X-ray crystal structure analysis and molecular docking study.[Pubmed: 15698804 ]Bioorg Med Chem. 2005 Mar 1;13(5):1867-72.Corynoline (1), a hexahydrobenzo[c]phenanthridine-type alkaloid, exhibited the concentration-dependent inhibition for the adhesion of human polymorphonuclear leukocyte and eosinophil to human umbilical vein cultured endothelial cell in the concentration range of showing no significant cytotoxicity for the cell: IC(50) value=72.4 microM for (d)-1 and 156.7 microM for (l)-1.
This shows the potent anti-inflammatory and/or immunosuppressive activity of 1.
|
| Kinase Assay | Inhibitory effect of corynoline isolated from the aerial parts of Corydalis incisa on the acetylcholinesterase.[Pubmed: 12510831]Arch Pharm Res. 2002 Dec;25(6):817-9.
|
| Structure Identification | Tetrahedron Letters Volume 27, Issue 19, 1986, Pages 2103–2106Synthesis of a hypothetical intermediate in the biosynthesis of the 13-methylbenzophenanthridine alkaloids corynoline and 14-epicorynoline and the B-secoprotoberberine alkaloid corydalic acid methyl ester[Reference: WebLink]A novel carbinolammonium chloride has been synthesized as a possible intermediate in the biosynthetic conversion of the 13-methylprotoberberine alkaloid (+)-tetrahydrocorysamine to the benzophenanthridine alkaloids (+)-Corynoline, (+)-14-epicorynoline, and the B-secoprotoberberine alkaloid (+)-corydalic acid methyl ester. |
(+)-Corynoline Dilution Calculator
(+)-Corynoline Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.7218 mL | 13.6091 mL | 27.2183 mL | 54.4366 mL | 68.0457 mL |
| 5 mM | 0.5444 mL | 2.7218 mL | 5.4437 mL | 10.8873 mL | 13.6091 mL |
| 10 mM | 0.2722 mL | 1.3609 mL | 2.7218 mL | 5.4437 mL | 6.8046 mL |
| 50 mM | 0.0544 mL | 0.2722 mL | 0.5444 mL | 1.0887 mL | 1.3609 mL |
| 100 mM | 0.0272 mL | 0.1361 mL | 0.2722 mL | 0.5444 mL | 0.6805 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
Calcutta University
University of Minnesota
University of Maryland School of Medicine
University of Illinois at Chicago
The Ohio State University
University of Zurich
Harvard University
Colorado State University
Auburn University
Yale University
Worcester Polytechnic Institute
Washington State University
Stanford University
University of Leipzig
Universidade da Beira Interior
The Institute of Cancer Research
Heidelberg University
University of Amsterdam
University of Auckland
TsingHua University
The University of Michigan
Miami University
DRURY University
Jilin University
Fudan University
Wuhan University
Sun Yat-sen University
Universite de Paris
Deemed University
Auckland University
The University of Tokyo
Korea University
- Arachidonyl serotonin
Catalog No.:BCC7500
CAS No.:187947-37-1
- Serpentine
Catalog No.:BCN1162
CAS No.:18786-24-8
- BIO 1211
Catalog No.:BCC3945
CAS No.:187735-94-0
- Fmoc-Asp-OFm
Catalog No.:BCC3467
CAS No.:187671-16-5
- PNU 142633
Catalog No.:BCC7222
CAS No.:187665-65-2
- PNU 109291
Catalog No.:BCC7408
CAS No.:187665-60-7
- Tataramide B
Catalog No.:BCN3897
CAS No.:187655-56-7
- Fmoc-D-Arg(Pbf)-OH
Catalog No.:BCC3077
CAS No.:187618-60-6
- Ethyl rutinoside
Catalog No.:BCC8976
CAS No.:187539-57-7
- MaxiPost
Catalog No.:BCC7984
CAS No.:187523-35-9
- N-Aminophthalimide
Catalog No.:BCC9085
CAS No.:1875-48-5
- Sitoindoside I
Catalog No.:BCN1161
CAS No.:18749-71-8
- Acetylcorynoline
Catalog No.:BCN1239
CAS No.:18797-80-3
- WKYMVM trifluoroacetate salt
Catalog No.:BCC5815
CAS No.:187986-11-4
- Trp-Lys-Tyr-Met-Val-Met
Catalog No.:BCC5816
CAS No.:187986-17-0
- 5-Acetyltaxachitriene A
Catalog No.:BCN7412
CAS No.:187988-48-3
- Boc-Glu-NH2
Catalog No.:BCC3387
CAS No.:18800-74-3
- Bikinin
Catalog No.:BCC5582
CAS No.:188011-69-0
- Abacavir sulfate
Catalog No.:BCC5023
CAS No.:188062-50-2
- Odoroside H
Catalog No.:BCN1163
CAS No.:18810-25-8
- AWD 131-138
Catalog No.:BCC4045
CAS No.:188116-07-6
- NocII
Catalog No.:BCC5704
CAS No.:188119-47-3
- H-Ser(tBu)-OH
Catalog No.:BCC3032
CAS No.:18822-58-7
- H-Tyr(tBu)-OH
Catalog No.:BCC3129
CAS No.:18822-59-8
Inhibitory effect of corynoline isolated from the aerial parts of Corydalis incisa on the acetylcholinesterase.[Pubmed:12510831]
Arch Pharm Res. 2002 Dec;25(6):817-9.
In the course of screening Korean natural products for acetylcholinesterase (AChE) inhibitory activity, it was found that a methanolic extract of the aerial parts of Corydalis incisa (Papaveraceae) showed significant inhibitory effects on AChE. Corynoline isolated from this plant inhibited AChE activity in a dose-dependent manner, and the IC50 value of corynoline was 30.6 microM. The AChE inhibitory activity of corynoline was reversible and noncompetitive.
Cell adhesion inhibitory activity of (d)-corynoline, a hexahydrobenzo[c]phenanthridine-type alkaloid, and its structure-activity relationship, studied by X-ray crystal structure analysis and molecular docking study.[Pubmed:15698804]
Bioorg Med Chem. 2005 Mar 1;13(5):1867-72.
Corynoline (1), a hexahydrobenzo[c]phenanthridine-type alkaloid, exhibited the concentration-dependent inhibition for the adhesion of human polymorphonuclear leukocyte and eosinophil to human umbilical vein cultured endothelial cell in the concentration range of showing no significant cytotoxicity for the cell: IC(50) value=72.4 microM for (d)-1 and 156.7 microM for (l)-1. This shows the potent anti-inflammatory and/or immunosuppressive activity of 1. To elucidate possible structure-activity relationship, the conformational/structural feature of (d)-1 was investigated by X-ray crystal structure analysis and molecular orbital energy calculations, and the docking study was performed for its interaction with the D1-domain of ICAM-1 (intracellular adhesion molecule-1). A plausible model was proposed, in which all polar atoms of (d)-1 are linked by hydrogen bonds or electrostatic interactions with the functional residues of ICAM-1, that have been supposed to be necessary for the binding with LFA-1 (leukocyte function-associated antigen-1). This suggests the potent inhibitory activity of 1 for the ICAM-1/LFA-1 adhesion and would be important on developing the clinically usable drugs for the inflammatory diseases.
