Complanatoside ACAS# 146501-37-3 |
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
| Cas No. | 146501-37-3 | SDF | Download SDF |
| PubChem ID | 122173248 | Appearance | Yellow powder |
| Formula | C27H30O18 | M.Wt | 642.5 |
| Type of Compound | Flavonoids | Storage | Desiccate at -20°C |
| Solubility | DMSO : ≥ 35.7 mg/mL (55.56 mM) *"≥" means soluble, but saturation unknown. | ||
| Chemical Name | 2-[3,5-dihydroxy-4-[(2R,3S,4R,5R,6S)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyphenyl]-5,7-dihydroxy-3-[(2R,3S,4R,5R,6S)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxychromen-4-one | ||
| SMILES | C1=C(C=C(C(=C1O)OC2C(C(C(C(O2)CO)O)O)O)O)C3=C(C(=O)C4=C(C=C(C=C4O3)O)O)OC5C(C(C(C(O5)CO)O)O)O | ||
| Standard InChIKey | LLVOJEYSNCNXJN-LALDPBHMSA-N | ||
| Standard InChI | InChI=1S/C27H30O18/c28-5-13-16(34)19(37)21(39)26(42-13)44-24-10(32)1-7(2-11(24)33)23-25(18(36)15-9(31)3-8(30)4-12(15)41-23)45-27-22(40)20(38)17(35)14(6-29)43-27/h1-4,13-14,16-17,19-22,26-35,37-40H,5-6H2/t13-,14-,16-,17-,19+,20+,21-,22-,26+,27+/m0/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
||
| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
||
| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | 1. Complanatoside A is a flavonol glycoside isolated from Astragalus complanatus, and currently it is used as a quality control index for A. complanatus in the 2010 edition of the Chinese Pharmacopoeia. |
Complanatoside A Dilution Calculator
Complanatoside A Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 1.5564 mL | 7.7821 mL | 15.5642 mL | 31.1284 mL | 38.9105 mL |
| 5 mM | 0.3113 mL | 1.5564 mL | 3.1128 mL | 6.2257 mL | 7.7821 mL |
| 10 mM | 0.1556 mL | 0.7782 mL | 1.5564 mL | 3.1128 mL | 3.8911 mL |
| 50 mM | 0.0311 mL | 0.1556 mL | 0.3113 mL | 0.6226 mL | 0.7782 mL |
| 100 mM | 0.0156 mL | 0.0778 mL | 0.1556 mL | 0.3113 mL | 0.3891 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
Calcutta University
University of Minnesota
University of Maryland School of Medicine
University of Illinois at Chicago
The Ohio State University
University of Zurich
Harvard University
Colorado State University
Auburn University
Yale University
Worcester Polytechnic Institute
Washington State University
Stanford University
University of Leipzig
Universidade da Beira Interior
The Institute of Cancer Research
Heidelberg University
University of Amsterdam
University of Auckland
TsingHua University
The University of Michigan
Miami University
DRURY University
Jilin University
Fudan University
Wuhan University
Sun Yat-sen University
Universite de Paris
Deemed University
Auckland University
The University of Tokyo
Korea University
Complanatoside A is a flavonol glycoside isolated from Astragalus complanatus, and currently it is used as a quality control index for A. complanatus in the 2010 edition of the Chinese Pharmacopoeia.
In Vitro:A simple and sensitive LC-MS/MS method is developed for the determination of complanatoside A in rat plasma over the range of 2.3–575 ng/mL. Complanatoside A is extracted from plasma by a protein precipitation procedure, separated by LC and detected by MS/MS in positive electrospray ionization mode. The lower limit of quantification is established at 2.3 ng/mL. Intra- and inter-day precisions (LLOQ, low-QC, med-QC and high-QC) are less than 7.9%, and accuracies are between 94.0 and 105.1%. Matrix effect is acceptable (97.9–103.0%) and extraction recovery is reproducible (88.5–94.4%). Complanatoside A is stable in the investigated conditions. The method is applied to the pharmacokinetics of complanatoside A in rats[1].
References:
[1]. Li N, et al. Quantification of complanatoside A in rat plasma using LC-MS/MS and its application to a pharmacokinetic study. Biomed Chromatogr. 2016 Jun;30(6):888-93.
- 1-Methylpsilocin
Catalog No.:BCC7536
CAS No.:1465-16-3
- Pralatrexate
Catalog No.:BCC2304
CAS No.:146464-95-1
- Camaric acid
Catalog No.:BCN1650
CAS No.:146450-83-1
- Flavopiridol
Catalog No.:BCC1577
CAS No.:146426-40-6
- Lactose
Catalog No.:BCN8387
CAS No.:14641-93-1
- Desmethylrocaglamide
Catalog No.:BCN7735
CAS No.:146408-78-8
- SR 48692
Catalog No.:BCC7763
CAS No.:146362-70-1
- N-Methyllidocaine iodide
Catalog No.:BCC6905
CAS No.:1462-71-1
- Chlorajapolide F
Catalog No.:BCN6425
CAS No.:1461760-59-7
- R-(-)-Deprenyl hydrochloride
Catalog No.:BCC5196
CAS No.:14611-52-0
- Z-Arg(Z)2-OH
Catalog No.:BCC3574
CAS No.:14611-34-8
- Pulchinenoside E1
Catalog No.:BCN8185
CAS No.:146100-02-9
- WR 1065
Catalog No.:BCC2417
CAS No.:14653-77-1
- Tyrphostin AG 1296
Catalog No.:BCC1195
CAS No.:146535-11-7
- Fmoc-Gly(allyl)-OH
Catalog No.:BCC3156
CAS No.:146549-21-5
- 2-Cyclopropyl-3-[(diphenylphosphinyl)methyl]-4-(4-fluorophenyl)quinoline
Catalog No.:BCC8572
CAS No.:146578-99-6
- 2,6-Dimethoxybenzoic acid
Catalog No.:BCN1651
CAS No.:1466-76-8
- Dantrolene, sodium salt
Catalog No.:BCC6673
CAS No.:14663-23-1
- H-Trp(Boc)-OH
Catalog No.:BCC3115
CAS No.:146645-63-8
- SR 2640 hydrochloride
Catalog No.:BCC7180
CAS No.:146662-42-2
- (RS)-MCPG
Catalog No.:BCC6610
CAS No.:146669-29-6
- SR 11237
Catalog No.:BCC7681
CAS No.:146670-40-8
- Hybridaphniphylline A
Catalog No.:BCN7042
CAS No.:1467083-07-3
- Hybridaphniphylline B
Catalog No.:BCN7045
CAS No.:1467083-09-5
[Determination of complanatoside A in semen Astragali complanati by HPLC].[Pubmed:16011285]
Zhongguo Zhong Yao Za Zhi. 2005 Apr;30(8):600-2.
OBJECTIVE: To establish the determination method for Complanatoside A in seeds of Astragalus complanatus. METHOD: An HPLC method has been developed to separate Complanatoside A on ZORBAX EXTEND-C18 (4.6 mm x 250 mm, 5 microm) column with acetonitrile-water-phosphoric acid (20:80:0.2) as mobile phase and UV detection at 267 nm. RESULT: The good linearity of Complanatoside A ranged 0.086-0.430 microg, r = 0.9999. An average recovery of 99.8% (n = 5) was obtained with a RSD of 1.0%. CONCLUSION: The established method is proved to be stability, fast, accurate and can be used for quantification of Complanatoside A in Semen Astragali Complanati.
Quantification of complanatoside A in rat plasma using LC-MS/MS and its application to a pharmacokinetic study.[Pubmed:26393341]
Biomed Chromatogr. 2016 Jun;30(6):888-93.
Complanatoside A is a flavonol glycoside isolated from Astragalus complanatus, and currently it is used as a quality control index for A. complanatus in the 2010 edition of the Chinese Pharmacopoeia. For the first time, a simple and sensitive LC-MS/MS method was developed for the determination of Complanatoside A in rat plasma over the range of 2.3-575 ng/mL. Complanatoside A was extracted from plasma by a protein precipitation procedure, separated by LC and detected by MS/MS in positive electrospray ionization mode. The method was validated for selectivity, carryover, sensitivity, linearity, extraction recovery, matrix effect, accuracy, precision and stability studies. The lower limit of quantification was established at 2.3 ng/mL. Intra- and inter-day precisions (LLOQ, low-QC, med-QC and high-QC) were <7.9%, and accuracies were between 94.0 and 105.1%. Matrix effect was acceptable (97.9-103.0%) and extraction recovery was reproducible (88.5-94.4%). Complanatoside A was stable in the investigated conditions. The method was applied to the pharmacokinetics of Complanatoside A in rats. Copyright (c) 2015 John Wiley & Sons, Ltd.
