(-)-Carvone

CAS# 6485-40-1

(-)-Carvone

Catalog No. BCN8949----Order now to get a substantial discount!

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Chemical structure

(-)-Carvone

3D structure

Chemical Properties of (-)-Carvone

Cas No. 6485-40-1 SDF Download SDF
PubChem ID 439570 Appearance Colorless liquid
Formula C10H14O M.Wt 150.22
Type of Compound Isoprenoids Storage Desiccate at -20°C
Synonyms L-CARVONE
Solubility Soluble in chloroform
Chemical Name (5R)-2-methyl-5-prop-1-en-2-ylcyclohex-2-en-1-one
SMILES CC1=CCC(CC1=O)C(=C)C
Standard InChIKey ULDHMXUKGWMISQ-SECBINFHSA-N
Standard InChI InChI=1S/C10H14O/c1-7(2)9-5-4-8(3)10(11)6-9/h4,9H,1,5-6H2,2-3H3/t9-/m1/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

(-)-Carvone Dilution Calculator

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(-)-Carvone Molarity Calculator

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Preparing Stock Solutions of (-)-Carvone

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 6.6569 mL 33.2845 mL 66.569 mL 133.1381 mL 166.4226 mL
5 mM 1.3314 mL 6.6569 mL 13.3138 mL 26.6276 mL 33.2845 mL
10 mM 0.6657 mL 3.3285 mL 6.6569 mL 13.3138 mL 16.6423 mL
50 mM 0.1331 mL 0.6657 mL 1.3314 mL 2.6628 mL 3.3285 mL
100 mM 0.0666 mL 0.3328 mL 0.6657 mL 1.3314 mL 1.6642 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on (-)-Carvone

Sustainable catalytic rearrangement of terpene-derived epoxides: towards bio-based biscarbonyl monomers.[Pubmed:32623988]

Philos Trans A Math Phys Eng Sci. 2020 Jul 24;378(2176):20190267.

Seeking a sustainable and selective approach for terpene modification, a catalyst deconvolution approach was applied to the Meinwald rearrangement of (+)-limonene oxide as a model substrate to yield dihydrocarvone. In order to identify the most suitable catalyst and reaction conditions, different Lewis acids were evaluated. Bismuth triflate proved to be the most active catalyst under mild reaction conditions, with a low catalyst loading (1 mol%) and a relatively short reaction time (3 h). The optimized reaction conditions were subsequently transferred to other terpene-based epoxides, yielding different bio-based biscarbonyl structures, which constitute interesting and valuable substances, e.g. for polymer synthesis or as fragrances. Monoepoxides derived from (R)-(-)-Carvone and (+)-dihydrocarvone rearranged to the desired products with high selectivities and yields. gamma-Terpinene dioxide could be transformed in a double rearrangement to the respective biscarbonyl in moderate yields. A better result was achieved for limonene dioxide after further adjustment of the protocol to reach acceptable yields with a low catalyst loading of 0.1 mol% using 2-methyl tetrahydrofuran as a sustainable solvent. Compared to many procedures described in the literature, this procedure represents a step towards an increased sustainability in terpene modification by considering several principles of Green Chemistry, such as renewable resources, catalysis and mild reaction conditions for elementary chemical transformations. This article is part of a discussion meeting issue 'Science to enable the circular economy'.

Composition and Antibacterial Effect of Mint Flavorings in Candies and Food Supplements.[Pubmed:32365392]

Planta Med. 2020 May 4.

Mint flavorings are widely used in confections, beverages, and dairy products. For the first time, mint flavoring composition of mint candies and food supplements (n = 45), originating from 16 countries, as well as their antibacterial properties, was analyzed. The flavorings were isolated by Marcusson's type micro-apparatus and analyzed by GC-MS. The total content of the mint flavoring hydrodistilled extracts was in the range of 0.01 - 0.9%. The most abundant compounds identified in the extracts were limonene, 1,8-cineole, menthone, menthofuran, isomenthone, menthol and its isomers, menthyl acetate. The antimicrobial activity of 13 reference substances and 10 selected mint flavoring hydrodistilled extracts was tested on Escherichia coli and Staphylococcus aureus by broth dilution method. Linalool acetate and (-)-Carvone, as most active against both bacteria, had the lowest MIC90 values. (+)-Menthyl acetate, (-)-menthyl acetate, and limonene showed no antimicrobial activity. Three of the tested extracts had antimicrobial activity against E. coli and 8 extracts against S. aureus. Their summary antimicrobial activity was not always in concordance with the activities of respective reference substances.

Standardised comparison of limonene-derived monoterpenes identifies structural determinants of anti-inflammatory activity.[Pubmed:32350292]

Sci Rep. 2020 Apr 29;10(1):7199.

Mint species are widely used in traditional and conventional medicine as topical analgesics for osteoarthritic pain and for disorders of the gastrointestinal and respiratory tracts which are all associated with chronic inflammation. To identify the structural determinants of anti-inflammatory activity and potency which are required for chemical optimization towards development of new anti-inflammatory drugs, a selected group of monoterpenes especially abundant in mint species was screened by measuring bacterial lipopolysacharide (LPS)-induced nitric oxide (NO) production in murine macrophages. Nine compounds significantly decreased LPS-induced NO production by more than 30%. IC50 values were calculated showing that the order of potency is: (S)-(+)-carvone > (R)-(-)-Carvone > (+)-dihydrocarveol > (S)-8-hydroxycarvotanacetone > (R)-8-hydroxycarvotanacetone > (+)-dihydrocarvone > (-)-carveol > (-)-dihydrocarveol > (S)-(-)-pulegone. Considering the carbon numbering relative to the common precursor, limonene, the presence of an oxygenated group at C6 conjugated to a double bond at C1 and an isopropenyl group and S configuration at C4 are the major chemical features relevant for activity and potency. The most potent compound, (S)-(+)-carvone, significantly decreased the expression of NOS2 and IL-1beta in macrophages and in a cell model of osteoarthritis using primary human chondrocytes. (S)-(+)-carvone may be efficient in halting inflammation-related diseases, like osteoarthritis.

Description

(-)-carvone is a carvone having (R) configuration. It is an enantiomer of a (+)-carvone.

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