AC 45594inverse agonist of steroidogenic factor 1 (SF-1) CAS# 13037-86-0 |
- Thrombin Receptor Agonist Peptide
Catalog No.:BCC3950
CAS No.:137339-65-2
- SLIGRL-NH2
Catalog No.:BCC3947
CAS No.:171436-38-7
- TFLLR-NH2
Catalog No.:BCC3948
CAS No.:197794-83-5
- AY-NH2
Catalog No.:BCC3949
CAS No.:352017-71-1
- ML161
Catalog No.:BCC3642
CAS No.:423735-93-7
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
| Cas No. | 13037-86-0 | SDF | Download SDF |
| PubChem ID | 25641 | Appearance | Powder |
| Formula | C13H20O2 | M.Wt | 208.3 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Solubility | Soluble in DMSO > 10 mM | ||
| Chemical Name | 4-heptoxyphenol | ||
| SMILES | CCCCCCCOC1=CC=C(C=C1)O | ||
| Standard InChIKey | HZBABTUFXQLADL-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C13H20O2/c1-2-3-4-5-6-11-15-13-9-7-12(14)8-10-13/h7-10,14H,2-6,11H2,1H3 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
||
| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
||
| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | Selective inverse agonist at the orphan nuclear receptor steroidogenic factor-1 (SF-1) (IC50= 50 - 100 nM). Displays no activity at estrogen, LRH-1, ROR, ERR or Nurr receptors. Inhibits SFRE-mediated transcription. |
AC 45594 Dilution Calculator
AC 45594 Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 4.8008 mL | 24.0038 mL | 48.0077 mL | 96.0154 mL | 120.0192 mL |
| 5 mM | 0.9602 mL | 4.8008 mL | 9.6015 mL | 19.2031 mL | 24.0038 mL |
| 10 mM | 0.4801 mL | 2.4004 mL | 4.8008 mL | 9.6015 mL | 12.0019 mL |
| 50 mM | 0.096 mL | 0.4801 mL | 0.9602 mL | 1.9203 mL | 2.4004 mL |
| 100 mM | 0.048 mL | 0.24 mL | 0.4801 mL | 0.9602 mL | 1.2002 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
Calcutta University
University of Minnesota
University of Maryland School of Medicine
University of Illinois at Chicago
The Ohio State University
University of Zurich
Harvard University
Colorado State University
Auburn University
Yale University
Worcester Polytechnic Institute
Washington State University
Stanford University
University of Leipzig
Universidade da Beira Interior
The Institute of Cancer Research
Heidelberg University
University of Amsterdam
University of Auckland
TsingHua University
The University of Michigan
Miami University
DRURY University
Jilin University
Fudan University
Wuhan University
Sun Yat-sen University
Universite de Paris
Deemed University
Auckland University
The University of Tokyo
Korea University
AC 45594 is a full inverse agonist of steroidogenic factor 1 (SF-1) with an IC50 value of 50~100 nM [1].
SF-1 is a constitutively nuclear hormone receptor. It is essential to the development of gonadal and adrenal glands. It acts as a shaping factor in sexual differentiation and determination. Its effects are exerted primarily via controlling steroid hormone synthesis [1].
Human adrenocortical H295R/TR SF-1 cells were overexpressing SF-1 in a Dox-inducible fashion. After a 4-day treatment with AC 45594, the proliferation of H295R/TR SF-1 cells cultured in basal conditions was inhibited in a dose-dependent manner. AC 45594 showed maximal effect at 10 µM. SF-1 overexpression induced cell proliferation. In the presence of Dox, incubation with AC 45594 at 1 µM markedly reduced the effect of SF-1 overexpression. Moreover, treatment with AC 45594 increased the percentage of sub-G1 (apoptotic) cells [2]. In human adrenocortical H295 cells, cAMP is able to induce the expression of StAR. This induction is dependent on the presence of SF-1. Incubation with AC 45594 dose-dependently reduced amounts of the StAR mRNA to basal levels. At the protein level, 24 h after the cAMP treatment, StAR was increased by 30-fold. But treatment with AC 45594 completely and dose-dependently reversed the cAMP-dependent activation of StAR [1].
No result regarding the effect of AC 45594 in animal bodies had been found.
References:
[1]. Del Tredici AL, Andersen CB, Currier EA, et al. Identification of the first synthetic steroidogenic factor 1 inverse agonists: pharmacological modulation of steroidogenic enzymes. Molecular pharmacology, 2008, 73(3): 900-908.
[2]. Doghman M, Cazareth J, Douguet D, et al. Inhibition of adrenocortical carcinoma cell proliferation by steroidogenic factor-1 inverse agonists. The Journal of Clinical Endocrinology & Metabolism, 2009, 94(6): 2178-2183.
- MI-773 (SAR405838)
Catalog No.:BCC5648
CAS No.:1303607-60-4
- MI-773
Catalog No.:BCC5155
CAS No.:1303607-07-9
- Cathayanon I
Catalog No.:BCN3678
CAS No.:1303438-52-9
- Cathayanon H
Catalog No.:BCN3570
CAS No.:1303438-51-8
- CI 988
Catalog No.:BCC7430
CAS No.:130332-27-3
- H-D-Phe-OMe.HCl
Catalog No.:BCC3013
CAS No.:13033-84-6
- Fmoc-Oic-OH
Catalog No.:BCC3305
CAS No.:130309-37-4
- Fmoc-D-Tic-OH
Catalog No.:BCC3342
CAS No.:130309-33-0
- HOE 140
Catalog No.:BCC5964
CAS No.:130308-48-4
- Fmoc-Asp(OcHex)-OH
Catalog No.:BCC3468
CAS No.:130304-80-2
- Rubiarbonol B
Catalog No.:BCN6159
CAS No.:130288-60-7
- PD 135158
Catalog No.:BCC7431
CAS No.:130285-87-9
- Batimastat (BB-94)
Catalog No.:BCC1223
CAS No.:130370-60-4
- Decinnamoyltaxagifine
Catalog No.:BCN7329
CAS No.:130394-69-3
- Pungiolide A
Catalog No.:BCN8128
CAS No.:130395-54-9
- 2-Oxokolavenol
Catalog No.:BCN4716
CAS No.:130395-82-3
- DL-AP5 Sodium salt
Catalog No.:BCC7753
CAS No.:1303993-72-7
- CHPG Sodium salt
Catalog No.:BCC7755
CAS No.:1303993-73-8
- (RS)-MCPG disodium salt
Catalog No.:BCC7756
CAS No.:1303994-09-3
- Paulownin
Catalog No.:BCN6160
CAS No.:13040-46-5
- (-)-Catechin gallate(CG)
Catalog No.:BCN5330
CAS No.:130405-40-2
- A-71623
Catalog No.:BCC7354
CAS No.:130408-77-4
- Peucedanocoumarin I
Catalog No.:BCN3434
CAS No.:130464-55-0
- Peucedanocoumarin II
Catalog No.:BCN3435
CAS No.:130464-56-1
