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5-Hydroxytryptamine

CAS# 50-67-9

5-Hydroxytryptamine

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Product Name & Size Price Stock
5-Hydroxytryptamine:5mg Please Inquire In Stock
5-Hydroxytryptamine:10mg Please Inquire In Stock
5-Hydroxytryptamine:20mg Please Inquire In Stock
5-Hydroxytryptamine:50mg Please Inquire In Stock

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Chemical structure

5-Hydroxytryptamine

3D structure

Chemical Properties of 5-Hydroxytryptamine

Cas No. 50-67-9 SDF Download SDF
PubChem ID 5202 Appearance Powder
Formula C10H12N2O M.Wt 176
Type of Compound N/A Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name 3-(2-aminoethyl)-1H-indol-5-ol
SMILES C1=CC2=C(C=C1O)C(=CN2)CCN
Standard InChIKey QZAYGJVTTNCVMB-UHFFFAOYSA-N
Standard InChI InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

5-Hydroxytryptamine Dilution Calculator

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5-Hydroxytryptamine Molarity Calculator

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Preparing Stock Solutions of 5-Hydroxytryptamine

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 5.6818 mL 28.4091 mL 56.8182 mL 113.6364 mL 142.0455 mL
5 mM 1.1364 mL 5.6818 mL 11.3636 mL 22.7273 mL 28.4091 mL
10 mM 0.5682 mL 2.8409 mL 5.6818 mL 11.3636 mL 14.2045 mL
50 mM 0.1136 mL 0.5682 mL 1.1364 mL 2.2727 mL 2.8409 mL
100 mM 0.0568 mL 0.2841 mL 0.5682 mL 1.1364 mL 1.4205 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on 5-Hydroxytryptamine

Chrysin ameliorates ANTU-induced pulmonary edema and pulmonary arterial hypertension via modulation of VEGF and eNOs.[Pubmed:30974023]

J Biochem Mol Toxicol. 2019 Apr 11:e22332.

Alpha-naphthylthiourea (ANTU), a rodenticide induces lung toxicity. Chrysin a flavonoid possesses antioxidant, anti-inflammatory, and antihypertensive potential. The aim of this study was to evaluate the efficacy of chrysin against ANTU-induced pulmonary edema (PE) and pulmonary arterial hypertension (PAH) in laboratory rats. Sprague-Dawley rats were used to induce PE (ANTU, 10 mg/kg, ip) and PAH (ANTU, 5 mg/kg, ip, 4 weeks). Animals were treated with chrysin (10, 20, and 40 mg/kg) and various biochemical, molecular, and histological parameters were evaluated. Acute administration of ANTU induces PE revealed by significant (P < 0.05) increase in relative lung weight, pleural effusion volume, lung edema, bronchoalveolar lavage fluid cell counts, total protein, 5-Hydroxytryptamine (5-HT), lactate dehydrogenase (LDH), and gamma-glutamyl transferase (GGT), whereas pretreatment with chrysin (20 and 40 mg/kg, ip) significantly (P < 0.05) attenuated these ANTU-induced biochemical and histological alterations. Repeated administration of ANTU caused induction of PAH evaluated by significant (P < 0.05) alterations in electrocardiographic, hemodynamic changes, and left ventricular function, whereas chrysin (20 and 40 mg/kg, p.o.) treatment significantly (P < 0.05) attenuated these alterations. ANTU-induced hematological and serum biochemical (aspartate transaminase, alanine transaminase, LDH, and creatinine kinase MB) alterations were significantly (P < 0.05) inhibited by chrysin. It also significantly (P < 0.05) decreased elevated levels of oxido-nitrosative stress in the right ventricle (RV) and lung. Chrysin significantly (P < 0.05) attenuated downregulated endothelial nitric oxide synthase and upregulated vascular endothelial growth factor messenger RNA and protein expressions both in the RV and pulmonary artery. Chrysin inhibited ANTU-induced PE and PAH via modulation of inflammatory responses (5-HT, LDH, and GGT), oxido-nitrosative stress, and VEGF and eNOs levels.

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