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5,7,3'-Trihydroxy-6,4',5'-trimethoxyflavone

CAS# 78417-26-2

5,7,3'-Trihydroxy-6,4',5'-trimethoxyflavone

Catalog No. BCN1353----Order now to get a substantial discount!

Product Name & Size Price Stock
5,7,3'-Trihydroxy-6,4',5'-trimethoxyflavone:5mg Please Inquire In Stock
5,7,3'-Trihydroxy-6,4',5'-trimethoxyflavone:10mg Please Inquire In Stock
5,7,3'-Trihydroxy-6,4',5'-trimethoxyflavone:20mg Please Inquire In Stock
5,7,3'-Trihydroxy-6,4',5'-trimethoxyflavone:50mg Please Inquire In Stock

Quality Control of 5,7,3'-Trihydroxy-6,4',5'-trimethoxyflavone

Number of papers citing our products

Chemical structure

5,7,3'-Trihydroxy-6,4',5'-trimethoxyflavone

3D structure

Chemical Properties of 5,7,3'-Trihydroxy-6,4',5'-trimethoxyflavone

Cas No. 78417-26-2 SDF Download SDF
PubChem ID 5496475 Appearance Yellow powder
Formula C18H16O8 M.Wt 360.3
Type of Compound Flavonoids Storage Desiccate at -20°C
Solubility Soluble in DMSO and methanol; insoluble in water
Chemical Name 5,7-dihydroxy-2-(3-hydroxy-4,5-dimethoxyphenyl)-6-methoxychromen-4-one
SMILES COC1=CC(=CC(=C1OC)O)C2=CC(=O)C3=C(C(=C(C=C3O2)O)OC)O
Standard InChIKey PMBOOVZSTMWOFS-UHFFFAOYSA-N
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of 5,7,3'-Trihydroxy-6,4',5'-trimethoxyflavone

1 Citrus sp. 2 Gardenia sp. 3 Lycium sp.

Biological Activity of 5,7,3'-Trihydroxy-6,4',5'-trimethoxyflavone

Description5,7,3'-Trihydroxy-6,4',5'-trimethoxyflavone is a natural product from Artemisia argyi.
In vitro

Further characterization of foliar flavonoids in Crossostephium chinense and their geographic variation.[Pubmed: 24689280]

Nat Prod Commun. 2014 Feb;9(2):163-4.


METHODS AND RESULTS:
Foliar flavonoids of Crossostephium chinense in Japan and Taiwan were isolated and further characterized. Eighteen flavonoid aglycones, luteolin, apigenin, hispidulin, chrysoeriol, 5,7,4'-trihydroxy-6,3',5'-trimethoxyflavone, jaceosidin, cilsimaritin, quercetin 3-methyl ether, axillarin, chrysosplenol-D, cirsiliol, apometzgerin, 5,7,3'-Trihydroxy-6,4',5'-trimethoxyflavone, luteolin 3',4'-dimethyl ether, cirsilineol, eupatilin, nepetin and 5,7,3',4'-tetrahydroxy-6,5'-dimethoxyflavone, were identified by UV, 1H and 13C NMR spectroscopic, LC-MS and HPLC comparisons w ith authentic samples. The compounds existed on the leaf surface. Four flavonoid glycosides, quercetin 3,7-di-O-glucoside, quercetin 3-O-rutinoside, luteolin 7-O-glucoside and apigenin 7-O-rutinoside, were also isolated as the intracellular flavonoids.
CONCLUSIONS:
It was shown by HPLC survey that variation of the species' flavonoids occurs among the collection sites.

Protocol of 5,7,3'-Trihydroxy-6,4',5'-trimethoxyflavone

Structure Identification
Zhong Yao Cai. 2013 May;36(5):752-5.

Chemical constituents from flowers of Gardenia jasminoides.[Pubmed: 24218967]

To study the chemical constituents from flowers of Gardenia jasminoides.
METHODS AND RESULTS:
The compounds were isolated and purified by column chromatography and their structures were elucidated through spectroscopic techniques (NMR) and physicochemical properties.15 compounds were isolated from flowers of G. jasminoides, and identified as 5,7,3'-Trihydroxy-6,4',5'-trimethoxyflavone (1), 5, 7, 3', 5'- tetrahydroxy-6, 4'-dymethoxyflavone (2), kaempferol (3), quercetin (4), 3beta,23- dihydroxyurs-12-en-28-oic acid (5), 3beta,19alpha-dihydroxy-urs-12-en-28-oic acid (6), 3beta,19alpha,23-trihydroxy-urs-12-en-28-oic acid (7), emodin (8), physcion (9), crocin-I (10), beta-daucosterol (11), beta-sitosterol (12), stearic acid (13), palmitic acid (14), oleic acid (15).
CONCLUSIONS:
Compounds 1 - 15 are isolated from flowers of G. jasminoides and compounds 5 and 6 are isolated from genus Gardenia for the first time.

5,7,3'-Trihydroxy-6,4',5'-trimethoxyflavone Dilution Calculator

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5,7,3'-Trihydroxy-6,4',5'-trimethoxyflavone Molarity Calculator

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Preparing Stock Solutions of 5,7,3'-Trihydroxy-6,4',5'-trimethoxyflavone

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.7755 mL 13.8773 mL 27.7546 mL 55.5093 mL 69.3866 mL
5 mM 0.5551 mL 2.7755 mL 5.5509 mL 11.1019 mL 13.8773 mL
10 mM 0.2775 mL 1.3877 mL 2.7755 mL 5.5509 mL 6.9387 mL
50 mM 0.0555 mL 0.2775 mL 0.5551 mL 1.1102 mL 1.3877 mL
100 mM 0.0278 mL 0.1388 mL 0.2775 mL 0.5551 mL 0.6939 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on 5,7,3'-Trihydroxy-6,4',5'-trimethoxyflavone

Further characterization of foliar flavonoids in Crossostephium chinense and their geographic variation.[Pubmed:24689280]

Nat Prod Commun. 2014 Feb;9(2):163-4.

Foliar flavonoids of Crossostephium chinense in Japan and Taiwan were isolated and further characterized. Eighteen flavonoid aglycones, luteolin, apigenin, hispidulin, chrysoeriol, 5,7,4'-trihydroxy-6,3',5'-trimethoxyflavone, jaceosidin, cilsimaritin, quercetin 3-methyl ether, axillarin, chrysosplenol-D, cirsiliol, apometzgerin, 5,7,3'-trihydroxy-6,4',5'-trimethoxyflavone, luteolin 3',4'-dimethyl ether, cirsilineol, eupatilin, nepetin and 5,7,3',4'-tetrahydroxy-6,5'-dimethoxyflavone, were identified by UV, 1H and 13C NMR spectroscopic, LC-MS and HPLC comparisons w ith authentic samples. The compounds existed on the leaf surface. Four flavonoid glycosides, quercetin 3,7-di-O-glucoside, quercetin 3-O-rutinoside, luteolin 7-O-glucoside and apigenin 7-O-rutinoside, were also isolated as the intracellular flavonoids. It was shown by HPLC survey that variation of the species' flavonoids occurs among the collection sites.

[Chemical constituents from flowers of Gardenia jasminoides].[Pubmed:24218967]

Zhong Yao Cai. 2013 May;36(5):752-5.

OBJECTIVE: To study the chemical constituents from flowers of Gardenia jasminoides. METHODS: The compounds were isolated and purified by column chromatography and their structures were elucidated through spectroscopic techniques (NMR) and physicochemical properties. RESULTS: 15 compounds were isolated from flowers of G. jasminoides, and identified as 5, 7, 3'-trihydroxy-6, 4', 5'-trimethoxyflavone (1), 5, 7, 3', 5'- tetrahydroxy-6, 4'-dymethoxyflavone (2), kaempferol (3), quercetin (4), 3beta,23- dihydroxyurs-12-en-28-oic acid (5), 3beta,19alpha-dihydroxy-urs-12-en-28-oic acid (6), 3beta,19alpha,23-trihydroxy-urs-12-en-28-oic acid (7), emodin (8), physcion (9), crocin-I (10), beta-daucosterol (11), beta-sitosterol (12), stearic acid (13), palmitic acid (14), oleic acid (15). CONCLUSION: Compounds 1 - 15 are isolated from flowers of G. jasminoides and compounds 5 and 6 are isolated from genus Gardenia for the first time.

Description

5,7,3'-Trihydroxy-6,4',5'-trimethoxyflavone is a methylated flavones from Artemisia frigida.

Keywords:

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