2'-MethoxykurarinoneCAS# 270249-38-2 |
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
| Cas No. | 270249-38-2 | SDF | Download SDF |
| PubChem ID | 11982641 | Appearance | Powder |
| Formula | C27H32O6 | M.Wt | 452.6 |
| Type of Compound | Flavonoids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | (2S)-7-hydroxy-2-(4-hydroxy-2-methoxyphenyl)-5-methoxy-8-[(2R)-5-methyl-2-prop-1-en-2-ylhex-4-enyl]-2,3-dihydrochromen-4-one | ||
| SMILES | CC(=CCC(CC1=C(C=C(C2=C1OC(CC2=O)C3=C(C=C(C=C3)O)OC)OC)O)C(=C)C)C | ||
| Standard InChIKey | KTAQQSUPNZAWEY-OSPHWJPCSA-N | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | 2'-Methoxykurarinone has strong alpha-glucosidase inhibitory activities, with IC(50) values of 155 microM. 2'-Methoxykurarinone is a noncompetitive inhibitor of protein tyrosine phosphatase 1B, it exhibits cellular activity in the insulin signaling pathway by increasing the insulin-stimulated Akt phosphorylation level in human hepatocellular liver carcinoma HepG2 cells, suggesting its potential for new anti-insulin-resistant drug developments. 2′-Methoxykurarinone exhibits lethal activity against Trypanosoma cruzi.,the minimum lethal concentrations is 6.9 uM. |
| Targets | Antifection | Akt |
| In vitro | Protein tyrosine phosphatase 1B inhibitory activity of lavandulyl flavonoids from roots of Sophora flavescens.[Pubmed: 24782228]Planta Med., 2014, 80(7):557-60.Protein tyrosine phosphatase 1B is a non-transmembrane protein tyrosine phosphatase and major negative regulator in insulin signaling cascades, and much attention has been paid to protein tyrosine phosphatase 1B inhibitors as potential therapies for diabetes.
Trypanocidal Flavonoids from Sophora flavescens[Reference: WebLink]Natural Medicines, 2003, 57:253-5.The acetone extract of Sophora flavescens Aiton (Leguminosae) exhibited lethal activity against Trypanosoma cruzi.
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| Kinase Assay | Glycosidase inhibitory flavonoids from Sophora flavescens.[Pubmed: 16462036]Biol. Pharm. Bull., 2006, 29(2):302-5.The methanol extract of Sophora flavescens showed a potent glycosidase inhibitory activity. |
2'-Methoxykurarinone Dilution Calculator
2'-Methoxykurarinone Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.2095 mL | 11.0473 mL | 22.0946 mL | 44.1891 mL | 55.2364 mL |
| 5 mM | 0.4419 mL | 2.2095 mL | 4.4189 mL | 8.8378 mL | 11.0473 mL |
| 10 mM | 0.2209 mL | 1.1047 mL | 2.2095 mL | 4.4189 mL | 5.5236 mL |
| 50 mM | 0.0442 mL | 0.2209 mL | 0.4419 mL | 0.8838 mL | 1.1047 mL |
| 100 mM | 0.0221 mL | 0.1105 mL | 0.2209 mL | 0.4419 mL | 0.5524 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Protein tyrosine phosphatase 1B inhibitory activity of lavandulyl flavonoids from roots of Sophora flavescens.[Pubmed:24782228]
Planta Med. 2014 May;80(7):557-60.
Protein tyrosine phosphatase 1B is a non-transmembrane protein tyrosine phosphatase and major negative regulator in insulin signaling cascades, and much attention has been paid to protein tyrosine phosphatase 1B inhibitors as potential therapies for diabetes. The screening of a natural compound library led to the discovery of five lavandulyl flavonoids, which were isolated from the roots of Sophora flavescens, as novel PTP1B inhibitors: kuraridin (1), norkurarinone (2), kurarinone (3), 2'-methoxykurarinone (4), and kushenol T (5). The three most potent compounds, 1, 2, and 4 (IC50 < 30 microM), were demonstrated to be noncompetitive inhibitors of protein tyrosine phosphatase 1B based on a kinetic analysis, and they exhibited different inhibitory selectivities against four homologous protein tyrosine phosphatases (T cell protein tyrosine phosphatase, vaccinia H1-related phosphatase, and Src homology domain 2-containing protein tyrosine phosphatases 1 and 2). Compounds 1, 2, and 4 also exhibited cellular activity in the insulin signaling pathway by increasing the insulin-stimulated Akt phosphorylation level in human hepatocellular liver carcinoma HepG2 cells, suggesting their potential for new anti-insulin-resistant drug developments.
Glycosidase inhibitory flavonoids from Sophora flavescens.[Pubmed:16462036]
Biol Pharm Bull. 2006 Feb;29(2):302-5.
The methanol extract of Sophora flavescens showed a potent glycosidase inhibitory activity. Active components were identified as well-known flavonoid antioxidants: kushenol A (1), (-)-kurarinone (2), sophoraflavanone G (3), 2'-methoxykurarinone (4), kurarinol (5), 8-prenylkaempferol (6), isoxanthohumol (7), kuraridin (8) and maackian (9). All flavonoids were effective inhibitors of alpha-glucosidase and beta-amylase. Interestingly, lavandulylated flavanones 1-5 had strong alpha-glucosidase inhibitory activities, with IC(50) values of 45 microM, 68 microM, 37 microM, 155 microM and 179 microM, respectively. Kushenol A (1) which does not bear a 4'-hydroxy group showed selective alpha-glucosidase inhibitory activity. Lavandulylated chalcone, kuraridine (8), exhibited IC(50) value of 57 microM against beta-glucosidase, which is the first report of a chalcone displaying glycosidase inhibition. Results showed that 8-lavandulyl group in B-ring was a key factor of the glycosidase inhibitory activities. The inhibition pattern was noncompetitive for alpha-glucosidase, whereas mixed inhibition was observed for beta-amylase.
