(E)-3-Hydroxy-5-methoxystilbeneCAS# 35302-70-6 |
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| Cas No. | 35302-70-6 | SDF | Download SDF |
| PubChem ID | 5281719 | Appearance | White powder |
| Formula | C15H14O2 | M.Wt | 226.3 |
| Type of Compound | Phenols | Storage | Desiccate at -20°C |
| Synonyms | 5-Methoxy-3-stilbenol;5150-38-9 | ||
| Solubility | Soluble in acetone and ethanol; practically insoluble in water | ||
| Chemical Name | 3-methoxy-5-[(E)-2-phenylethenyl]phenol | ||
| SMILES | COC1=CC(=CC(=C1)O)C=CC2=CC=CC=C2 | ||
| Standard InChIKey | JVIXPWIEOVZVJC-BQYQJAHWSA-N | ||
| Standard InChI | InChI=1S/C15H14O2/c1-17-15-10-13(9-14(16)11-15)8-7-12-5-3-2-4-6-12/h2-11,16H,1H3/b8-7+ | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
The herbs of Jatropha curcas
| Description | 1. (E)-3-Hydroxy-5-methoxystilbene possesses inhibitory activity against several Gram-positive bacteria, including isolates of methicillin-resistant Staphylococcus aureus (MRSA), Mycobacterium bovis BCG, and avirulent Bacillusanthracis (Sterne strain), among others. |
| Targets | Antifection |
(E)-3-Hydroxy-5-methoxystilbene Dilution Calculator
(E)-3-Hydroxy-5-methoxystilbene Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 4.4189 mL | 22.0946 mL | 44.1891 mL | 88.3783 mL | 110.4728 mL |
| 5 mM | 0.8838 mL | 4.4189 mL | 8.8378 mL | 17.6757 mL | 22.0946 mL |
| 10 mM | 0.4419 mL | 2.2095 mL | 4.4189 mL | 8.8378 mL | 11.0473 mL |
| 50 mM | 0.0884 mL | 0.4419 mL | 0.8838 mL | 1.7676 mL | 2.2095 mL |
| 100 mM | 0.0442 mL | 0.2209 mL | 0.4419 mL | 0.8838 mL | 1.1047 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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New classes of Gram-positive selective antibacterials: inhibitors of MRSA and surrogates of the causative agents of anthrax and tuberculosis.[Pubmed:18849164]
Bioorg Med Chem Lett. 2008 Nov 1;18(21):5745-9.
An antimicrobial phenolic stilbene, (E)-3-Hydroxy-5-methoxystilbene, 1 was recently isolated from the leaves of Comptonia peregrina (L.) Coulter and shown to possess inhibitory activity against several Gram-positive bacteria, including isolates of methicillin-resistant Staphylococcus aureus (MRSA), Mycobacterium bovis BCG, and avirulent Bacillusanthracis (Sterne strain), among others. These results prompted the design and synthesis of two new classes of compounds, phenoxystyrenes and phenothiostyrenes, as analogs of the natural antimicrobial stilbene. These and additional stilbenoid analogs were synthesized using new, efficient, copper-mediated coupling strategies. Minimum inhibitory concentration (MIC) antimicrobial assays were performed on all compounds prepared. These preliminary structure-activity relationship studies indicated that both new classes of synthetic analogs, as well as the stilbenes, show promising activity against Gram-positive bacteria when at least one phenolic moiety is present, but not when absent. The potencies of the phenolic phenoxystyrenes and phenothiostyrenes were found to be comparable to those of the phenolic stilbenes tested.
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