Flemingia macrophylla a is woody leguminous shrub belonging to the genus Flemingia. It is a multipurpose plant widely used in agriculture, crop improvement, fodder, dyes and for various therapeutic purposes. A number of bioactive compounds have been reported from F. macrophylla. Like other members of Fabaceae, it is rich in Flavonoids. Genistein, 5, 7,3’, 4’-tetrahydroxyisoflavone, 5, 7, 4’-trihydroxyisoflavone-7-O-β-D-glucopyranoside, 5, 7,4’-trihydroxy-8,3’-diprenylflavanone, 5, 7,4’-trihydroxy-6-prenylisoflavone, flemichin D, lespedezaflavanone A and ouratea-catechin are isolated from the root, in which genistein and its isoflavones analogs are the main constituents. A novel flavanone, named fleminone, was isolated from a petrol extract of the stems. A new isoflavone, called flemiphyllin was also isolated. Three new flavonoids, fleminginin (1), flemingichromone (2), and flemingichalcone (3), and other twenty known compounds were isolated from the aerial parts.