Cornus officinalis is a species of dogwood known also as Japanese cornel or Japanese cornelian cherry or Cornelian cherries.It occurs in China, Japan and Korea where it is used as a food plant and as a medicinal plant-Shan-zhu-yu,(Chinese) San-syu-yu (Japanese). The fruits of Cornus officinalis have been used in traditional oriental medicine for treatment of inner ear diseases, such as tinnitus and hearing loss. The plant contains oleanolic acid and ursolic acid. Ursolic acid has shown in vitro protective effects on auditory cells. Ethanolic extracts of the fruit of C. officinalis has been shown to prevent hepatic injuries associated with acetaminophen-induced liver injury-induced hepatotoxicity (in mice) by preventing or alleviating oxidative stress. The chemical constituents isolated from the fruit (Corni fructus) have protective effects on beta cells in vitro, and may control postprandial hyperglycemia by alpha-glucosidase inhibition.