Colchicum autumnale, commonly known as autumn crocus, meadow saffron or naked lady, is a flower which resembles the true crocuses, but flowers in autumn. The name "naked lady" comes from the fact that the flowers emerge from the ground long after the leaves have died back. Colchicum autumnale is the only species of its genus native to the United Kingdom, with notable populations under the stewardship of the County Wildlife Trusts. The bulb-like corms of Colchicum autumnale contain colchicine, a useful drug with a narrow therapeutic index. Colchicine is approved by the US FDA for the treatment of gout and familial Mediterranean fever. Colchicine is also used in plant breeding to produce polyploid strains. A synthetic chemical compound, called ICT2588, which is similar to one from the autumn crocus, is in the early stages of drug development for the treatment of some types of cancer.