A diterpene alkaloid with formula C25H41NO9 that is isolated from several Aconitum species.
Aconine can inhibit RANKL-induced osteoclast differentiation in RAW264.7 cells by suppressing NF-κB and NFATc1 activation and DC-STAMP expression.[1]
Aconine has GW26-e4470 effect on the expression of Sirt-1 and eNOS system in EAhy926 cell injured by Homocysteine.[2]
Aconine can attenuate hepatic fat degeneration of rats with fatty liver induced by high-fat diet through decreasing TG,TC deposit in liver.[3]
[1] Zeng X Z, He L G, Wang S, et al. Acta Pharmacol Sin, 2015, 37(2):255-63.
[2] Liu Y, Zheng Z, Zhou B, et al. J Am Coll Cardiol, 2015, 66(16):C92-3.
[3] Shou Z X, Fan H.Journal of Shandong University of Traditional Chinese Medicine, 2008, 32(2):166-8.
[4] Liu M, Zhang H, Cai Y M, et al.Journal of Pharmaceutical Practice, 2013, 31(3):181-4.
