Bryonolic acid

Catalog No. BCN5103
CAS RN 24480-45-3
Molecular Weight 456.7
Molecular Formula C30H48O3
Database [PubChem]:382158969
[ChEBI]:65846
[PCIDB]:29859

Definition

A pentacyclic triterpenoid of D:C-friedooleanane-type triterpenoids isolated from the stems of Lagenaria siceraria and roots of Coriaria intermedia and has been found to exhibit antineoplastic activity.

Standard InChI

InChI=1S/C30H48O3/c1-25(2)21-9-8-20-19(28(21,5)12-11-23(25)31)10-13-30(7)22-18-27(4,24(32)33)15-14-26(22,3)16-17-29(20,30)6/h21-23,31H,8-18H2,1-7H3,(H,32,33)/t21-,22+,23-,26+,27-,28+,29+,30-/m0/s1

Biological Activity

Bryonolic acid(BA), isolated in high yield from transformed hairy root cultures of Trichosanthes kirilowii var. Japonica, it exhibits cytotoxic activity to various tumor cells in vitro, independent of cell type. [1]
Bryonolic acid can induce a marked increase in the expression of a phase 2 response enzyme, heme oxygenase 1 (HO-1), in a dose-dependent manner. [2]
Bryonolic acid can protect PC12 cells against NMDA-induced apoptosis by inhibiting Ca2+ influx and regulating gene expression in the Ca2+-CaMKII-CREB signal pathway, supports that BA may be a promising neuroprotective agent for the treatment of cerebral ischemia disease.[3]
Bryonolic acid has anti-inflammatory and antioxidant activities, can reduce the inflammatory mediator NO by suppressing the expression of the inflammatory enzyme inducible nitric oxide synthase (iNOS) in LPS-activated RAW 264.7 macrophage cells; can induce the antioxidant protein heme oxygenase-1 (HO-1) in vitro and in vivo in an Nrf2-dependent manner. [4]
Bryonolic Acid is an anti-allergic triterpene.[5]

Product information

English website: Bryonolic acid
Japanese website: Bryonolic acid
Chinese website: Bryonolic acid

References

[1] Kondo T, Inoue M, Mizukami H, et al. Biol Pharm Bull, 1995, 18(5):726-9.
[2] Barker E C, Gatbontonschwager T N, Han Y, et al. J Nat Prod, 2010, 73(6):1064-8.
[3] Que J, Ye M, Zhang Y, et al. Molecules, 2016, 21(4):418.
[4] Gatbonton-Schwager T N, Letterio J J, Tochtrop G P. J Nat Prod, 2012, 75(4):591-8.
[5] Tabata M, Tanaka S, Cho H J, et al. J Nat Prod, 1993, 56(2):165-74.
[6] Barker E C, Gatbontonschwager T N, Han Y, et al. J Nat Prod, 2010, 73(6):1064-8.