Phytochemical analysis and antibacterial activity of methanolic extract of Bergenia purpurascens against common respiratory infection causing bacterial species in vitro and in neonatal rats.[Pubmed: 29366865]

Respiratory bacterial infections are responsible for significant mortality across the world and with emergence of drug resistant bacterial strains there is urgent need to look for new treatment options. In this study we evaluated the antimicrobial activity of methanolic extract of Bergenia purpurasceus in vitro and in neonatal rats. The results of the present study revealed that the methanolic extract exhibits antimicrobial activity against all the bacterial species with MIC ranging from 75 to 150 μg/ml. The antibacterial activity of the Bergenia purpurasceus extract was also determined in the neonatal rat models wherein it was observed that administration of 50 and 100 mg/kg doses of Bergenia purpurasceus extract improved the survival of the neonatal rats infected with S. aureus. Furthermore, the extract showed considerable antioxidant activity which was positively associated with the phenolics and flavonoids content. Finally the constituents responsible for the bioactivity of the extract were identified and found to be bergenin, catechin, naringenin, myricetin and gallic acid. Takentogether, these results indicate that Bergenia purpurasceus extract could prove useful for the treatment of bacterial respiratory infections.

A new aromatic glycoside and its anti-proliferative activities from the leaves of Bergenia purpurascens.[Pubmed: 28602105]

None

12-Membered Resorcylic Acid Lactones Isolated from Saccharicola bicolor, an Endophytic Fungi from Bergenia purpurascens.[Pubmed: 26882683]

Two new resorcylic acid lactones, 13-hydroxyhidroresorcylide (1) and 12-hydroxyhidroresorcylide (2), along with four known congeners (3-6) were isolated from Saccharicola bicolor, an endophytic fungus from Bergenia purpurascens. Their structures were elucidated by interpretation of the spectroscopic evidence.

Study on the antibacterial activity of Bergenia purpurascens extract.[Pubmed: 25435634]

Bergenia purpurascens has tonic, haemostatic and anti-tussive actions. Anti-inflammatory and anti-bacterial activities of Bergenia purpurascens have not been reported so far. The objective of this paper is to provide experimental basis for the clinical application of Bergenia purpurascens through the pharmacodynamic study on its anti-inflammatory and anti-bacterial effects.

[Research on growth state and physiological changes of Tianquan Bergenia purpurascens under different shade conditions].[Pubmed: 21506405]

To study the growth index and physiological index of Tianquan Bergenia purpurascens under different shade conditions (100%, 80%, 60%, 40%, 20%), and investigate its adaptation mechanism to shade environment so that it can provide theoretical basis for cultivation and production.

[Comparative studies on content of arbutin, bergenin and catechin in different part of Bergenia purpurascens and B. crassifolia].[Pubmed: 21046733]

To develop a HPLC method for the determination of arbutin, bergenin and catechin in Chinese herb Bergenia, and to provide a scientific basis for evaluating the quality and reasonable utilization of the herb.

[Comparison of arbutin contents from Bergenia purpurascens in Yunnan].[Pubmed: 20939273]

To determine arbutin contents in different populations of Bergenia purpurascens in Yunnan province, for screening out the best resource and best part of B. purpurascens.