Products with Metal-chelators bioactivity
| Cat.No. | Product Name |
|---|---|
| BCN3261 | Chebulanin |
| 1. Chebulanin is a topoisomerase I inhibitor. 2. Chebulanin inhibits the calcineurin pathway in C. neoformans. 3. Chebulanin exhibits potent antifungal activity against various human pathogenic fungi with minimum inhibitory concentrations ranging from 0.25 to over 64 μg/ml. 4. Chebulanin suppresses the expression of inflammatory mediators and prevents cartilage destruction and bone erosion in mice, therefore, chebulanin is a strong therapeutic alternative for the treatment of rheumatism arthritis. 5. Chebulanin shows strong radical scavenging activity, good potency to chelate Fe2⁺ and good inhibition ability of lipid peroxidation. 6. Chebulanin has apparent capacities of inhibiting the survival of MCF-7 human cancer cell line. | |
| BCN3396 | Hypocrellin A |
| 1. Hypocrellin A , an a natural perylene quinine photosensitizers (PSs), can chelate with heavy metal ions, including Au(III) and Pt(IV), to form a 1:2 complex . 2. Hypocrellin A has light-induced antitumor activity . 3. Hypocrellin A has antifungal and antiviral activities. 4. Hypocrellin A exerts immunomodulatory effects on MHC-restricted presentation of antigen. | |
| BCN3895 | beta-Thujaplicin |
| 1. Hinokitiol can inhibit ultraviolet B-induced apoptosis in keratinocytes and strongly suggest that the inhibitory mechanism is due to the antioxidant activity of metallothionein induced by the agent. 2. Hinokitiol has antibacterial effect , it can inhibit all Staphylococcus aureus isolates with MICs of 1.56-3.13 mg/L. 3. Hinokitiol has antifungal activity against 51 Malassezia pachydermatis strains, it is an inexpensive and safe treatment with anti-inflammatory and deodorant effects that can be recommended as an effective remedy for canine otitis externa. 4. beta-thujaplicin (Hinokitiol) has ability to extract mitochondrial Mg++ and the prevention of the effects of beta-thujaplicin by an excess of Mg++ in the medium, suggests a common mode of action of beta-thujaplicin as a lipophilic chelator of Mg++ and other divalent cations. | |
| BCN5374 | Citric acid |
| Citric acid is a natural preservative and food tartness enhancer, it is also an Al-chelating substance and a natural antioxidant. Citric acid (1-2 g/kg) can decrease brain lipid peroxidation and inflammation, liver damage, and DNA fragmentation. Citric acid has phytoremediation of heavy metal contaminated soil; citric acid can decrease the adsorption of both lead and cadmium. Dietary citric acid can effectively improve phytate P utilization in chicks. | |
| BCN5571 | Tetrahydroamentoflavone |
| 1. (2S,2″S )-Tetrahydroamentoflavone exerts its antioxidant activity in vitro through metal-chelating, and radical-scavenging, which is via donating a hydrogen atom (H61) and an electron (e). 2. Tetrahydroamentoflavone is a potent XO inhibitor, may be considered as a drug candidate or chemopreventive agent. 3. Tetrahydroamentoflavone has anti-inflammatory effects, it shows in vitro cyclooxygenase (COX) inhibition activity ( an IC(50) value of 29.5 microM (COX-1) and 40.5% inhibition at 100 microg/mL (COX-2)). | |
