Products with Carcinogens bioactivity
| Cat.No. | Product Name |
|---|---|
| BCN2133 | Riddelline |
| 1. Riddelline is a potent genotoxic agent in vitro and induces significant elevations in unscheduled DNA synthesis and S-phase synthesis in rat liver. | |
| BCN2160 | Sodium barbital |
| 1. Sodium barbital was used as a model non-genotoxic renal carcinogen to test whether a concentration that increased renal tubular proliferation without severe nephrotoxicity would enhance tumor induction in a hereditary tumor model. 2. Sodium barbital causes progression to the stage of spontaneous renal lesions in Tsc2 mutant rats but do not increase their overall number. 3. Sodium barbital is a depressant of the central nervous system, has sedative/hypnotic effects. 4. Sodium barbital as an inhibitor of rabbit-muscle creatine kinase (CK), it might compete with both creatine and ATP, but mainly with creatine, to inhibit the activity of CK. 5. Sodium barbital is a tumour promoter, it can shorten the otherwise long latency between exposure to toxin and tumourigenesis. | |
| BCN2217 | Tartrazine |
| Tartrazine is a food additive that belongs to a class of artificial dyes and contains an azo group; it has significant genotoxic effect , may be harmful to health and its prolonged use could trigger carcinogenesis. | |
| BCN2511 | 12-O-tetradecanoylphorbol-13-acetate |
| 1. 12-O-tetradecanoylphorbol-13-acetate has skin tumor-promoting potential. 2. 12-O-tetradecanoylphorbol-13-acetate induces endogenous FBXO10 mRNA and FBXO10 protein in Jurkat cells, a human T cell line. 3. 12-O-tetradecanoylphorbol-13-acetate provokes cell motility through regulating the expression and function of S100A14 in a KLF4-dependent manner. | |
| BCN2658 | Aristolochic acid C |
| 1. Aristolochic acid(AA) is a powerful nephrotoxic and carcinogenic substance with an extremely short latency period, not only in animals but also in humans, in particular, the highly similar metabolic pathway of activation and resultant DNA adducts of AA allows the extrapolation of carcinogenesis data from laboratory animals to the human situation; therefore, all products containing botanicals known to or suspected of containing AA should be banned from the market world wide. | |
