Products with Antidepressant bioactivity
| Cat.No. | Product Name |
|---|---|
| BCN5612 | Orcinol |
| Orcinol glucoside is anxiolytic agent without sedative effect, it improves depressive behaviour in CUMS rats by downregulating HPA axis hyperactivity and increasing BDNF expression and ERK1/2 phosphorylation in the hippocampus. | |
| BCN5687 | Magnolol |
| Magnolol is a dual agonist of both RXRα and PPARγ, with EC50 values of 10.4 μM and 17.7 μM, respectively. Magnolol has antifungal, antibacterial, anti-oxidative, antidepressant-like, anti- tumor, and neuroprotective effects, it also prevents skin photoaging in UVB-irradiated hairless mice. Magnolol has a wide spectrum of targets including TNF-α, NF-KB, GSK3β. | |
| BCN5746 | beta-Amyrin |
| 1. alpha- and beta-Amyrin have hepatoprotective potential against toxic liver injury, the diminution in oxidative stress and toxic metabolite formation as likely mechanisms involved in its hepatoprotection. 2. alpha- and beta-Amyrin have antinociceptive properties in inflammatory models of pain, the mechanisms involved in their action are not completely understood but seem to involve the inhibition of protein kinase A- and protein kinase C-sensitive pathways. 3. alpha- and beta-Amyrin have anti-inflammatory potential, they retard acute inflammation in rat model of periodontitis and warrant further study on its efficacy to prevent chronic periodontitis-associated bone loss. 4. alpha- and beta-Amyrin mixture has gastro-protective activity, the mechanism involves at least in part the activation of capsaicin-sensitive primary afferent neurons. 5. alpha- and beta-Amyrin mixture has sedative and anxiolytic effects, the mechanism may involve an action on benzodiazepine-type receptors, and also an antidepressant effect where noradrenergic mechanisms will probably play a role. 6. Beta-Amyrin can enhance the total sleeping behavior in pentobarbital-induced sleeping model via the activation of GABAergic neurotransmitter system through GABA content in the brain. 7. beta-Amyrin has antiviral activity. | |
| BCN5944 | Liquiritin |
| Liquiritin possesses antidepressant-like, neuroprotective , antioxidant, antiapoptosis, anti-inflammatory and anti-cancer abilities. Liquiritin can attenuate advanced glycation end products-induced endothelial dysfunction via RAGE/NF-κB pathway in human umbilical vein endothelial cells, it may be a promising agent for the treatment of vasculopathy in diabetic patients. | |
| BCN5945 | Isoliquiritin |
| 1. Isoliquiritoside has antioxidant activity,remarkable anti-tumor and anti-HIV effects. 2. Isoliquiritoside shows strong inhibition against pancreatic lipase ( IC50 of 37.6 uM ). | |
