Products with Antibacterial bioactivity
| Cat.No. | Product Name |
|---|---|
| BCN3894 | Gliotoxin |
| 1. Gliotoxin targets nuclear NOTCH2 in human solid tumor derived cell lines in vitro and inhibits melanoma growth in xenograft mouse model. 2. Gliotoxin exhibits very strong anti-tuberculosis activity towards Mycobacterium tuberculosis with the the prominent MIC50 value of <0.03 uM. 3. Gliotoxin displays significant selective cytotoxicities against K562, A549 and Huh-7 cell lines with the IC50 values of 0.191, 0.015 and 95.4 uM, respectively. 4. Gliotoxin suppresses macrophage immune function by subverting phosphatidylinositol 3,4,5-trisphosphate homeostasis. 5. Gliotoxin, a Wnt signaling pathway inhibitor, induces growth inhibition and apoptosis in multiple colorectal cancer cell lines with mutations of the Wnt signaling pathway. | |
| BCN3895 | beta-Thujaplicin |
| 1. Hinokitiol can inhibit ultraviolet B-induced apoptosis in keratinocytes and strongly suggest that the inhibitory mechanism is due to the antioxidant activity of metallothionein induced by the agent. 2. Hinokitiol has antibacterial effect , it can inhibit all Staphylococcus aureus isolates with MICs of 1.56-3.13 mg/L. 3. Hinokitiol has antifungal activity against 51 Malassezia pachydermatis strains, it is an inexpensive and safe treatment with anti-inflammatory and deodorant effects that can be recommended as an effective remedy for canine otitis externa. 4. beta-thujaplicin (Hinokitiol) has ability to extract mitochondrial Mg++ and the prevention of the effects of beta-thujaplicin by an excess of Mg++ in the medium, suggests a common mode of action of beta-thujaplicin as a lipophilic chelator of Mg++ and other divalent cations. | |
| BCN3921 | Haplopine |
| 1. Haplopine shows photo-activated antimicrobial activity against S. aureus. 2. Haplopine exhibits potent melanogenesis-inhibitory activities with almost no toxicity to the cells. | |
| BCN3924 | Aristolactam AII |
| 1. Aristolactam AII has cytotoxic activity. 2. Aristolactam AII shows platelet aggregation inhibitory activity. | |
| BCN3954 | Pedalitin |
| 1. Pedalitin is a mixed-type inhibitor of tyrosinase. 2. In the assay of α-glucosidase inhibition, rosmarinic acid is a competitive inhibitor, whereas both methyl rosmarinate and Pedalitin are mixed-type inhibitors. | |
