Products with Anti-inflammatory bioactivity
| Cat.No. | Product Name |
|---|---|
| BCN6458 | Isorhynchophylline |
| 1. Isorhynchophylline exerts anticancer and anti-metastatic effects through regulation of multiple signaling cascades in hepatocellular carcinoma cells. 2. Isorhynchophylline exerts neuroprotective effect against Aβ 25-35-induced neurotoxicity in vitro via PI3K/Akt signaling pathway. 3. Isorhynchophylline shows antidepressant-like effects, which are mediated, at least in part, by the inhibition of monoamine oxidases. 4. Isorhynchophylline shows inhibition on angiotensin II-induced proliferation in rat vascular smooth muscle cells. 5. Isorhynchophylline shows anti-inflammatory effects in mouse N9 microglial cells. 6. Isorhynchophylline plays a remarkably preventive role in cardiac arrhythmias through the inhibition of calcium currents in rats and guinea pigs. | |
| BCN6466 | Boeravinone B |
| 1. Boeravinone B exhibits significant anti-inflammatory activity (56.6% at 50 mg/kg) when evaluated in an in vivo carrageenan-induced rat paw model. 2. Boeravinone B, a novel efflux pump inhibitor, apart from inhibiting the MdeA mediated efflux, also significantly inhibit the biofilm formation of S. aureus, boeravinone B may be used in combination with mupirocin for further development. | |
| BCN6475 | Okanin |
| 1. Okanin shows significant activities on both linoleic acid peroxidation inhibition and DPPH radical scavenging effect. 2. Okanin shows significant protective effects against tacrine-induced cytotoxicity in human liver-derived Hep G2 cells with the EC50 value of 29.8±1.1 uM. 3. Okanin can inhibit nitric oxide production and inducible nitric oxide synthase expression via nuclear factor-erythroid 2-related factor 2-dependent heme oxygenase-1 expression in lipopolysaccharide-activated macrophages. 4. Okanin attenuates LPS-induced microglial activation through inhibition of the TLR4/NF-κB signaling pathways, suggests that okanin may have potential as a nutritional preventive strategy for neurodegenerative disorders. | |
| BCN6479 | Desoxyrhapontigenin |
| 1. Desoxyrhapontigenin shows significant monoamine oxidase inhibitory activities with the IC50 value of 11.5 ± 1.1 uM. 2. Desoxyrhapontigenin up-regulates Nrf2-mediated heme oxygenase-1(HO-1) expression in macrophages and inflammatory lung injury, and HO-1 is an important anti-inflammatory, antioxidative and cytoprotective enzyme. 3. Desoxyrhapontigenin shows anti-inflammatory properties by the inhibition of iNOS and COX-2 expression via the down-regulation of the MAPK signaling pathways and the inhibition of NF-κB and Akt activation. 4. Desoxyrhapontigenin and desoxyrhaponticin have significant hypoglycemic and antioxidant effects. | |
| BCN6480 | Quercetagetin-7-O-glucoside |
| 1. Quercetagetin-7-O-glucoside, quercetagetin, quercetagetin 3'-methyl ether 7-O-glucoside, patuletin, and patuletin 7-O-glucoside are "yellow flavonols", and it was shown that the flower colors of three yellow-flowered species are due to these compounds. 2. Quercetagetin-7-O-glucoside, a potent inhibitor of beta-glucuronidase and lysozyme release, shows anti-inflammatory activity, can significantly inhibit arachidonic acid release from membranes. | |
