Nociception

Nociception is the sensory process that provides the signals that lead to pain. This occurs through nociceptors, primary sensory neurons that are activated by stimuli that cause tissue damage. Stimuli can include tissue injury, extremes of heat and noxious chemicals. Unlike other sensory neurons that detect vision or taste, nociceptors are located all around the body, particularly under the skin, however, they are notably absent from the brain.

Nociception Products Targets

Products for Nociception - Page 38

Cat.No. Product Name Information/Activity
BCC7664 PNU 177864 hydrochloride 250266-51-4
BCC7887 SB 277011A dihydrochloride SB-277011 dihydrochloride (SB-277011A dihydrochloride) is a potent, selective, orally bioavailable and brain penetrate dopamine D3 receptor antagonist, with pKis of 8.0, 6.0, <5.2 and 5.9 for D3, D2, 5-HT1B, and 5-HT1D receptors, respectively.
BCC7029 U 99194 maleate 234757-41-6
BCC6224 A 412997 dihydrochloride Selective D<sub>4</sub> agonist
BCC7293 ABT 724 trihydrochloride ABT-724 trihydrochloride is a potent and highly selective dopamine D4 receptor agonist with an EC50 of 12.4 nM for human dopamine D4 receptor. ABT-724 trihydrochloride is a potent partial agonist at the rat D4 (EC50 of 14.3 nM) and the ferret D4 receptor (EC50 of 23.2 nM), and has no effect on dopamine D1, D2, D3, or D5 receptors. ABT-724 trihydrochloride could be useful for the treatment of erectile dysfunction and has favorable side-effect profile.
BCC6919 PD 168077 maleate PD-168077 maleate is a selective dopamine D4 receptor agonist, with a Ki of 9 nM.
BCC7330 Ro 10-5824 dihydrochloride Ro 10-5824 dihydrochloride is a selective dopamine D4 receptor partial agonist, with Ki of 5.2 nM.
BCC2054 WAY-100635 maleate salt WAY-100635 maleate salt is a potent and selective 5-hydroxytryptamine 1A (5-HT1A) receptor antagonist with an IC50 value of 0.91 nM and Ki value of 0.39 nM. WAY-100635 maleate salt has pIC50 values for 5-HT1A and α1-adrenergic receptors of 8.9 and 6.6, respectively. WAY-100635 maleate salt is also a potent dopamine D4 receptor agonist.
BCC7440 Fananserin Fananserin (RP 62203) is an orally bioavailable, potent and selective 5-hydroxytryptamine2 (5-HT2) receptor antagonist, with a Ki of 0.37 nM for the rat 5-HT2A receptor. Fananserin also is a selective dopamine D4 receptor antagonist, with a Ki of 2.93 nM for the human dopamine D4 receptor.
BCC5696 L-741,742 hydrochloride 874882-93-6