Hedgehog Signaling
The Hedgehog (Hh) signaling pathway is crucial in the development of all animals. In the embryo, it regulates morphogenesis of a variety of tissues and organs; in the adult, it controls stem cell proliferation. There are three known human Hh proteins: Shh, Dhh and Ihh.
Products for Hedgehog Signaling - Page 2
- Cat.No. Product Name Information/Activity
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BCC6254
SMANT hydrochloride
1177600-74-6
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BCC7136
U 18666A
U18666A, a cell permeable drug, is a cholesterol synthesis and transport inhibitor.
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BCC7937
20(S)-Hydroxycholesterol
20(S)-hydroxyCholesterol (20α-Hydroxycholesterol) is an allosteric activator of the oncoprotein smoothened (Smo) that activates the hedgehog (Hh) signaling pathway with an EC50 of 3 μM in a gene transcription reporter assay using NIH3T3 cells.
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BCC6390
SAG
SAG is a potent Smo receptor agonist which activates the Hedgehog signaling pathway with a Kd of 59 nM.
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BCC7621
Thiostrepton
Thiostrepton is a natural cyclic oligopeptide antibiotic, is a natural product of the ribosomally synthesized and post-translationally modified peptide (RiPP) class.
