Ubiquitin E3 Ligase
Ubiquitin E3 ligases (EC 6.3.2.19) attach ubiquitin molecules onto lysine residues of proteins in order to target the protein for a specific cellular process, such as proteasomal degradation or an alteration in subcellular localization.
Products for Ubiquitin E3 Ligase
- Cat.No. Product Name Information/Activity
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BCC2408
HLI 373
Hdm2 inhibitor; activates p53-dependent transcription
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BCC2255
NSC 66811
MDM2 inhibitor. Disrupts MDM2-p53 interaction
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BCC6354
PRT 4165
PRT4165 is a potent inhibitor of PRC1 (Polycomb-repressive complex 1)-mediated H2A ubiquitylation.
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BCC5111
PTC-209
PTC-209 is a specific BMI-1 inhibitor with an IC50 of 0.5 μM.
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BCC2238
RITA (NSC 652287)
RITA is an inhibitor of p53-HDM-2 interaction, binds to p53dN, with a Kd of 1.5 nM, and also induces DNA-DNA cross-links.
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BCC6298
Skp2 Inhibitor C1
Skp2 Inhibitor C1(SKPin C1) is a specific small molecule inhibitor of Skp2-mediated p27 degradation, selectively inhibited Skp2-mediated p27 degradation by reducing p27 binding through key compound-receptor contacts.
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BCC6152
SMER 3
67200-34-4
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BCC8004
SZL P1-41
SZL P1-41 is a specific Skp2 inhibitor, binds to the F-box domain of Skp2 to prevent Skp1 association and Skp2 SCF complex formation. SZL P1-41, like Skp2 deficiency, augments p27-mediated apoptosis/senescence, while it impairs Akt-driven glycolysis. Anti-tumor activities.
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BCC2874
Tos-Arg-OMe.HCl
TAME hydrochloride is an inhibitor of anaphase-promoting complex/cyclosome (APC/C or APC), which binds to APC/C and prevents its activation by Cdc20 and Cdh1, produces mitotic arrest.
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BCC2239
Tenovin-1
Tenovin-1 is an inhibitor of sirtuin 1 and sirtuin 2, an activator of p53 and may have potential in the management of cancer.
