TRPP
The polycystin transient receptor potential (TRPP) channels are a subfamily of TRP channels that, when mutated, can lead to polycystic kidney disease. TRPP channels are divided into two distinct groups, polycystic kidney disease 1-like and polycystic kidney disease 2-like.
Products for TRPP
- Cat.No. Product Name Information/Activity
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BCC7674
Benzamil
Benzamil hydrochloride (Benzylamiloride hydrochloride), an Amiloride analogue, is a Na+/Ca2+ exchanger (NCX) inhibitor (IC50~100 nM). Benzamil hydrochloride also is a non-selective Deg/epithelial sodium channels (ENaC) blocker, and can potentiate myogenic vasoconstriction. Benzamil hydrochloride inhibits TRPP3-mediated Ca2+-activated currents, with an IC50 of 1.1 μM.
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BCC7672
EIPA
EIPA (L593754) is a TRPP3 channel inhibitor with an IC50 of 10.5 μM. EIPA also inhibits Na+/H+-exchanger (NHE) and macropinocytosis.
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BCC7673
Phenamil
1161-94-0
