WZ8040

EGFR T790M inhibitor,irreversible amd potent CAS# 1214265-57-2

WZ8040

Catalog No. BCC1075----Order now to get a substantial discount!

Product Name & Size Price Stock
WZ8040: 5mg $138 In Stock
WZ8040: 10mg Please Inquire In Stock
WZ8040: 20mg Please Inquire Please Inquire
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Quality Control of WZ8040

Number of papers citing our products

Chemical structure

WZ8040

3D structure

Chemical Properties of WZ8040

Cas No. 1214265-57-2 SDF Download SDF
PubChem ID 44607531 Appearance Powder
Formula C24H25ClN6OS M.Wt 481.01
Type of Compound N/A Storage Desiccate at -20°C
Synonyms WZ-8040;WZ 8040
Solubility Soluble in DMSO > 10 mM
Chemical Name N-[3-[5-chloro-2-[4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]sulfanylphenyl]prop-2-enamide
SMILES CN1CCN(CC1)C2=CC=C(C=C2)NC3=NC=C(C(=N3)SC4=CC=CC(=C4)NC(=O)C=C)Cl
Standard InChIKey KIISCIGBPUVZBF-UHFFFAOYSA-N
Standard InChI InChI=1S/C24H25ClN6OS/c1-3-22(32)27-18-5-4-6-20(15-18)33-23-21(25)16-26-24(29-23)28-17-7-9-19(10-8-17)31-13-11-30(2)12-14-31/h3-10,15-16H,1,11-14H2,2H3,(H,27,32)(H,26,28,29)
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Biological Activity of WZ8040

DescriptionWZ8040 is an irreversible inhibitor of EGFR T790M with IC50 value of <10nM.
TargetsEGFR T790M    
IC50<10nM     

WZ8040 Dilution Calculator

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WZ8040 Molarity Calculator

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Preparing Stock Solutions of WZ8040

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.079 mL 10.3948 mL 20.7896 mL 41.5792 mL 51.974 mL
5 mM 0.4158 mL 2.079 mL 4.1579 mL 8.3158 mL 10.3948 mL
10 mM 0.2079 mL 1.0395 mL 2.079 mL 4.1579 mL 5.1974 mL
50 mM 0.0416 mL 0.2079 mL 0.4158 mL 0.8316 mL 1.0395 mL
100 mM 0.0208 mL 0.1039 mL 0.2079 mL 0.4158 mL 0.5197 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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Background on WZ8040

WZ8040 is a novel, irreversible mutant-selective EGFR kinase inhibitor that specifically inhibits phosphorylation of EGFRT790M.

WZ8040 shows to suppress the growth of EGFR T790M containing cell lines as well as inhibit phosphorylation of EGFR in the Non–Small-Cell Lung Cancer (NSCLC) cells. WZ8040 was identified from the screen that possessed up to a 300-fold lower IC50 against the PC9GR cells compared to clinical stage inhibitors such as HKI-272 [1].

References:
[1] Zhou W1, Ercan D, Chen L, Yun CH, Li D, Capelletti M, Cortot AB, Chirieac L, Iacob RE, Padera R, Engen JR, Wong KK, Eck MJ, Gray NS, Jänne PA. Novel mutant-selective EGFR kinase inhibitors against EGFR T790M. Nature. 2009 Dec 24;462(7276):1070-4. doi: 10.1038/nature08622.

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Description

WZ8040 is an irreversible mutated EGFR T790M inhibitor and inhibits EGFR phosphorylation. WZ8040 displays 100-fold greater activity against the mutated EGFR than the normal.

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