TeucrenoneCAS# 152511-43-8 |
Quality Control & MSDS
Number of papers citing our products
Chemical structure
| Cas No. | 152511-43-8 | SDF | Download SDF |
| PubChem ID | N/A | Appearance | Solid |
| Formula | C15H22O2 | M.Wt | 234.37 |
| Type of Compound | Sesquiterpenoids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
Teucrenone Dilution Calculator
Teucrenone Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 4.2668 mL | 21.3338 mL | 42.6676 mL | 85.3352 mL | 106.6689 mL |
| 5 mM | 0.8534 mL | 4.2668 mL | 8.5335 mL | 17.067 mL | 21.3338 mL |
| 10 mM | 0.4267 mL | 2.1334 mL | 4.2668 mL | 8.5335 mL | 10.6669 mL |
| 50 mM | 0.0853 mL | 0.4267 mL | 0.8534 mL | 1.7067 mL | 2.1334 mL |
| 100 mM | 0.0427 mL | 0.2133 mL | 0.4267 mL | 0.8534 mL | 1.0667 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Integrated UPLC-MS/MS and UHPLC-Q-orbitrap HRMS Analysis to Reveal Pharmacokinetics and Metabolism of Five Terpenoids from Alpiniae oxyphyllae Fructus in Rats.[Pubmed:33334283]
Curr Drug Metab. 2021;22(1):70-82.
BACKGROUND: Alpiniae oxyphyllae Fructus (AOF), a traditional Chinese medicine (TCM), is widely used in the treatment of urinary, gastrointestinal and neurologic diseases in China. Although terpenoids are the main active ingredients of AOF, there are few researches on their pharmacokinetics and metabolism. METHODS: In this study, a sensitive, rapid, accurate and novel ultra high performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) method was established to evaluate the pharmacokinetic behavior of five terpenoids (oxyphyllenodiol B, (4S*,5E,10R*)-7-oxo-tri-nor-eudesm-5-en-4beta-ol, 7-epi-Teucrenone, (+)- (4R,5S,7R)-13-hydroxynootkatone, (E)-labda-12,14-dien-15(16)-olide-17-oic acid) in rats after oral administration of AOF extracts. 27 metabolic metabolites of the five terpenoids were identified by ultra high performance liquid chromatography -Q Exactive hybrid quadrupole-orbitrap high-resolution accurate mass spectrometry (UHPLC-Q-Orbitrap HRMS) based on precise mass and fragment ions. RESULTS: The established pharmacokinetic analysis method showed good linearity over a wide concentration range, and the lower quantitative limit (LLOQ) ranged from 0.97 to 4.25 ng/mL. Other validation parameters were within the acceptable range. In addition, 27 metabolites were identified in plasma, urine and feces samples, and the metabolic pathways of five terpenoids were mainly focused on glucoside conjugation, dehydration, desaturation and glycine conjugation. CONCLUSION: This is the first study on the pharmacokinetics and metabolism of five terpenoids in AOF, illuminating the disposal process of terpenoids in vivo. It was expected that the results of this study would provide some references for the apprehension of the action mechanism and the further pharmacological study of five terpenoids in AOF.
Dictyophorines A and B, two stimulators of NGF-synthesis from the mushroom Dictyophora indusiata.[Pubmed:9272967]
Phytochemistry. 1997 Jul;45(6):1203-5.
Two novel eudesmane-type sesquiterpenes, dictyophorines A and B, and a known compound, Teucrenone, were isolated from the mushroom Dictyophora indusiata. Dictyophorines A and B promoted nerve growth factor (NGF)-synthesis by astroglial cells.
