Tetrindole mesylateMAO-A inhibitor CAS# 170964-68-8 |
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
| Cas No. | 170964-68-8 | SDF | Download SDF |
| PubChem ID | 54792409 | Appearance | Powder |
| Formula | C21H30N2O3S | M.Wt | 390.54 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Solubility | Soluble to 100 mM in DMSO | ||
| SMILES | CS(=O)(=O)O.C1CCC(CC1)C2=CC3=C(C=C2)N4CCNC5C4=C3CCC5 | ||
| Standard InChIKey | CWPNPYVNPOAMHY-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C20H26N2.CH4O3S/c1-2-5-14(6-3-1)15-9-10-19-17(13-15)16-7-4-8-18-20(16)22(19)12-11-21-18;1-5(2,3)4/h9-10,13-14,18,21H,1-8,11-12H2;1H3,(H,2,3,4) | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
||
| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
||
| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | Novel antidepressant, a selective inhibitor of MAO-A. |
Tetrindole mesylate Dilution Calculator
Tetrindole mesylate Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.5606 mL | 12.8028 mL | 25.6056 mL | 51.2111 mL | 64.0139 mL |
| 5 mM | 0.5121 mL | 2.5606 mL | 5.1211 mL | 10.2422 mL | 12.8028 mL |
| 10 mM | 0.2561 mL | 1.2803 mL | 2.5606 mL | 5.1211 mL | 6.4014 mL |
| 50 mM | 0.0512 mL | 0.2561 mL | 0.5121 mL | 1.0242 mL | 1.2803 mL |
| 100 mM | 0.0256 mL | 0.128 mL | 0.2561 mL | 0.5121 mL | 0.6401 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
Calcutta University
University of Minnesota
University of Maryland School of Medicine
University of Illinois at Chicago
The Ohio State University
University of Zurich
Harvard University
Colorado State University
Auburn University
Yale University
Worcester Polytechnic Institute
Washington State University
Stanford University
University of Leipzig
Universidade da Beira Interior
The Institute of Cancer Research
Heidelberg University
University of Amsterdam
University of Auckland
TsingHua University
The University of Michigan
Miami University
DRURY University
Jilin University
Fudan University
Wuhan University
Sun Yat-sen University
Universite de Paris
Deemed University
Auckland University
The University of Tokyo
Korea University
- Dihydroactinidiolide
Catalog No.:BCN6890
CAS No.:17092-92-1
- Donitriptan hydrochloride
Catalog No.:BCC7742
CAS No.:170911-68-9
- Aburatubolactam A
Catalog No.:BCN1821
CAS No.:170894-24-3
- Persianone
Catalog No.:BCN7359
CAS No.:170894-20-9
- Cyasterone
Catalog No.:BCN5416
CAS No.:17086-76-9
- Sonepiprazole
Catalog No.:BCC7879
CAS No.:170858-33-0
- PNU 96415E
Catalog No.:BCC7467
CAS No.:170856-41-4
- (RS)-APICA
Catalog No.:BCC6925
CAS No.:170847-18-4
- E4CPG
Catalog No.:BCC6888
CAS No.:170846-89-6
- CHPG
Catalog No.:BCC6910
CAS No.:170846-74-9
- Astressin
Catalog No.:BCC5790
CAS No.:170809-51-5
- Trityl candesartan cilexetil
Catalog No.:BCC9188
CAS No.:170791-09-0
- EGLU
Catalog No.:BCC6871
CAS No.:170984-72-2
- H-Ser(tBu)-OMe.HCl
Catalog No.:BCC3033
CAS No.:17114-97-5
- PD 158780
Catalog No.:BCC7434
CAS No.:171179-06-9
- N-Methylquipazine dimaleate
Catalog No.:BCC6697
CAS No.:171205-17-7
- Posaconazole
Catalog No.:BCC1103
CAS No.:171228-49-2
- TAPI-1
Catalog No.:BCC5400
CAS No.:171235-71-5
- (RS)-AMPA hydrobromide
Catalog No.:BCC6926
CAS No.:171259-81-7
- Delphinidin-3-O-arabinoside chloride
Catalog No.:BCN3021
CAS No.:171370-55-1
- Ethyl 4-hydroxyphenylacetate
Catalog No.:BCN3792
CAS No.:17138-28-2
- Calcium Gluceptate
Catalog No.:BCC3743
CAS No.:17140-60-2
- Otophylloside B 4'''-O-alpha-L-cymaropyranoside
Catalog No.:BCN7511
CAS No.:171422-82-5
- Otophylloside B 4'''-O-beta-D-cymaropyranoside
Catalog No.:BCN7522
CAS No.:171422-85-8
Hemodynamic effects of tetrindol in alert normotensive mice and rats after blockade of nitric oxide synthesis.[Pubmed:11177242]
Bull Exp Biol Med. 2000 Aug;130(8):777-9.
Single intravenous injection of antidepressant tetrindol (1 and 10 mg/kg), a reversible monoamine oxidase A inhibitor, dose-dependently decreased heart rate and mean arterial pressure (in a concentration of 10 mg/kg) in alert NMRI mice and Sprague-Dawley rats. Nitric oxide synthase blockade with L-NAME attenuated tetrindol-induced bradycardia in rats and completely abolished this effect in mice.
Resolution, EPC-syntheses, absolute stereochemistry, and pharmacology of the (S)-(+)- and (R)-(-)-isomers of the MAO-A inhibitor tetrindole hydrochloride.[Pubmed:7492268]
Arch Pharm (Weinheim). 1995 Jul-Aug;328(7-8):619-22.
Resolution of (RS)-tetrindole (3) and enantioselective reductions of the imine 7 yielded (S)-(+)-(4) and (R)-(-)-tetrindole (5). The absolute stereochemistry of 4 was established by X-ray analysis of the corresponding Mosher amide 6. From in vitro as well as in vivo data (MAO-inhibition, levels of monoamines and their respective metabolites in rat brain), 4 was identified as the eutomer.
Monoamine oxidase inhibition by novel antidepressant tetrindole.[Pubmed:8304974]
Biochem Pharmacol. 1994 Jan 20;47(2):303-8.
The novel antidepressant tetrindole (2,3,3a,4,5,6-hexahydro-8-cyclohexyl-1H[3,2,1-j,k] carbazole) was found to be a selective inhibitor of monoamine oxidase A (MAO A). In vitro it inhibited rat brain mitochondrial MAO A in a competitive manner with Ki value of 0.4 microM. A 60 min preincubation did not change the competitive mode of interaction between enzyme and tetrindole (Ki value was 0.27 microM). The inhibition of rat brain mitochondrial MAO B was of mixed type with Ki value of 110 microM. Dilution or dialysis of mitochondrial suspension did not restore MAO A activity after inhibition by tetrindole both in vitro and in vivo, whereas inhibition of MAO B in vitro was completely reversible. Oral administration of tetrindole inhibited rat brain and liver mitochondrial MAO A by 80% within 0.5-1 hr and the onset of recovery of enzyme activity became evident after 24 hr. A small inhibition of MAO B (-20-30%) was observed in isolated brain and liver mitochondria within 1-6 hr and enzyme activity had completely recovered after 16 hr. The data obtained indicate that antidepressant activity of tetrindole may be explained by selective inhibition of MAO A, however an apparent discrepancy between competitive manner of MAO A inhibition in vitro and poor recovery of enzyme activity in vivo does not allow us to decide whether tetrindole is a "tight-binding" reversible inhibitor or a selective irreversible inhibitor of MAO A.
