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Isotanshinone IIB

CAS# 109664-01-9

Isotanshinone IIB

Catalog No. BCN2513----Order now to get a substantial discount!

Product Name & Size Price Stock
Isotanshinone IIB:5mg Please Inquire In Stock
Isotanshinone IIB:10mg Please Inquire In Stock
Isotanshinone IIB:20mg Please Inquire In Stock
Isotanshinone IIB:50mg Please Inquire In Stock

Quality Control of Isotanshinone IIB

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Chemical structure

Isotanshinone IIB

3D structure

Chemical Properties of Isotanshinone IIB

Cas No. 109664-01-9 SDF Download SDF
PubChem ID 184102 Appearance Red powder
Formula C19H18O4 M.Wt 310.35
Type of Compound Diterpenoids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name 4-(hydroxymethyl)-4,8-dimethyl-2,3-dihydro-1H-naphtho[2,1-f][1]benzofuran-7,11-dione
SMILES CC1=COC2=C1C(=O)C3=C(C2=O)C4=C(C=C3)C(CCC4)(C)CO
Standard InChIKey VIDDDTBBUDIKKK-UHFFFAOYSA-N
Standard InChI InChI=1S/C19H18O4/c1-10-8-23-18-14(10)16(21)12-5-6-13-11(15(12)17(18)22)4-3-7-19(13,2)9-20/h5-6,8,20H,3-4,7,9H2,1-2H3
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Isotanshinone IIB

The roots of Salvia miltiorrhiza Bge.

Biological Activity of Isotanshinone IIB

Description1. Tanshinol protects against hydrogen peroxide-induced oxidative stress via regulating Wnt/FoxO pathway in osteoblastic differentiation of C2C12 cells. 2. Tanshinol protects hippocampus and attenuates vascular dementia development, it may be a potential compound in vascular dementia (VD) model. 3. Tanshinol protects against atherosclerosis by preventing H2O2-induced apoptosis of human umbilical vein endothelial cells (HUVECs), these effects appear to be mediated by enhancing the antioxidant defenses and preserving the mitochondrial function of the cells. 4. Tanshinol can stimulate bone formation and attenuate dexamethasone-induced inhibition of osteogenesis in larval zebrafish. 5. Tanshinol attenuates oxidative stress via down-regulation of FoxO3a signaling, and rescues the decrease of osteoblastic differentiation through upregulation of Wnt signal under oxidative stress.
TargetsWnt/β-catenin

Isotanshinone IIB Dilution Calculator

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Isotanshinone IIB Molarity Calculator

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Preparing Stock Solutions of Isotanshinone IIB

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.2222 mL 16.1108 mL 32.2217 mL 64.4434 mL 80.5542 mL
5 mM 0.6444 mL 3.2222 mL 6.4443 mL 12.8887 mL 16.1108 mL
10 mM 0.3222 mL 1.6111 mL 3.2222 mL 6.4443 mL 8.0554 mL
50 mM 0.0644 mL 0.3222 mL 0.6444 mL 1.2889 mL 1.6111 mL
100 mM 0.0322 mL 0.1611 mL 0.3222 mL 0.6444 mL 0.8055 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Isotanshinone IIB

Isolation and bioactivity of new tanshinones.[Pubmed:3655791]

J Nat Prod. 1987 Mar-Apr;50(2):157-60.

Two new diterpenoids, designated neocryptotanshinone and Isotanshinone IIB, have been isolated from "Tan-Shen," the root of Salvia miltiorrhiza, together with a known compound, danshexinkun A. Their structures are established by spectral and physical data. Isotanshinone IIB exhibits significant inhibitory activity in vitro on ADP- and collagen-induced aggregation.

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