TCS PrP Inhibitor 13Antiprion agent; potently inhibits PrP-res accumulation CAS# 34320-83-7 |
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Quality Control & MSDS
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Chemical structure
3D structure
| Cas No. | 34320-83-7 | SDF | Download SDF |
| PubChem ID | 2750328 | Appearance | Powder |
| Formula | C15H11N3O3 | M.Wt | 281.27 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Solubility | Soluble to 100 mM in DMSO and to 25 mM in ethanol | ||
| Chemical Name | 5-(4-nitrophenyl)-2-phenyl-4H-pyrazol-3-one | ||
| SMILES | C1C(=NN(C1=O)C2=CC=CC=C2)C3=CC=C(C=C3)[N+](=O)[O-] | ||
| Standard InChIKey | FDAVFKZPGQEGDX-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C15H11N3O3/c19-15-10-14(11-6-8-13(9-7-11)18(20)21)16-17(15)12-4-2-1-3-5-12/h1-9H,10H2 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | Antiprion agent. Potently inhibits protease-resistant prion protein (PrP-res) accumulation in two types of prion-infected mouse neuroblastoma (N2a) cell lines (IC50 = 3 nM). |
TCS PrP Inhibitor 13 Dilution Calculator
TCS PrP Inhibitor 13 Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 3.5553 mL | 17.7765 mL | 35.553 mL | 71.1061 mL | 88.8826 mL |
| 5 mM | 0.7111 mL | 3.5553 mL | 7.1106 mL | 14.2212 mL | 17.7765 mL |
| 10 mM | 0.3555 mL | 1.7777 mL | 3.5553 mL | 7.1106 mL | 8.8883 mL |
| 50 mM | 0.0711 mL | 0.3555 mL | 0.7111 mL | 1.4221 mL | 1.7777 mL |
| 100 mM | 0.0356 mL | 0.1778 mL | 0.3555 mL | 0.7111 mL | 0.8888 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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New series of antiprion compounds: pyrazolone derivatives have the potent activity of inhibiting protease-resistant prion protein accumulation.[Pubmed:17850126]
J Med Chem. 2007 Oct 18;50(21):5053-6.
To find effective antiprion compounds, we synthesized and evaluated various pyrazolone derivatives. Seven of 19 compounds showed inhibition of PrP-res accumulation and the remarkably active compound 13 showed an IC50 value of 3 nM in both ScN2a and F3 cell lines. Findings from studies on physicochemical and biochemical properties suggest that the action mechanism of these compounds does not correlate with any antioxidant activities, any of hydroxyl radical scavenging activities, or any SOD-like activities.
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