SulfamethoxypyridazineCAS# 80-35-3 |
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Quality Control & MSDS
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Chemical structure
3D structure
| Cas No. | 80-35-3 | SDF | Download SDF |
| PubChem ID | 5330 | Appearance | Powder |
| Formula | C11H12N4O3S | M.Wt | 280.3 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Solubility | DMSO : ≥ 42 mg/mL (149.84 mM) *"≥" means soluble, but saturation unknown. | ||
| Chemical Name | 4-amino-N-(6-methoxypyridazin-3-yl)benzenesulfonamide | ||
| SMILES | COC1=NN=C(C=C1)NS(=O)(=O)C2=CC=C(C=C2)N | ||
| Standard InChIKey | VLYWMPOKSSWJAL-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C11H12N4O3S/c1-18-11-7-6-10(13-14-11)15-19(16,17)9-4-2-8(12)3-5-9/h2-7H,12H2,1H3,(H,13,15) | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | Sulfamethoxypyridazine is a long-acting sulfonamide antibiotic, for treatment of Dermatitis herpetiformis. |
Sulfamethoxypyridazine Dilution Calculator
Sulfamethoxypyridazine Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 3.5676 mL | 17.838 mL | 35.6761 mL | 71.3521 mL | 89.1902 mL |
| 5 mM | 0.7135 mL | 3.5676 mL | 7.1352 mL | 14.2704 mL | 17.838 mL |
| 10 mM | 0.3568 mL | 1.7838 mL | 3.5676 mL | 7.1352 mL | 8.919 mL |
| 50 mM | 0.0714 mL | 0.3568 mL | 0.7135 mL | 1.427 mL | 1.7838 mL |
| 100 mM | 0.0357 mL | 0.1784 mL | 0.3568 mL | 0.7135 mL | 0.8919 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Sulfamethoxypyridazine is a long-acting sulfonamide for treatment of Dermatitis herpetiformis.
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Fabrication of 2D nanosheet through self assembly behavior of sulfamethoxypyridazine inclusion complexes with alpha- and beta-cyclodextrins.[Pubmed:24394532]
Spectrochim Acta A Mol Biomol Spectrosc. 2014 Apr 5;123:158-66.
A 2D nanosheet was fabricated through the supramolecular self assembly of Sulfamethoxypyridazine (SMP) and beta-cyclodextrin (beta-CD) inclusion complexes. HRTEM image exhibited 2D nanosheet morphology with a length of 1200mm and the sheet thickness of 60mm. It is noted that the nanosheet did not form a single layer aggregation but a bulk aggregation of SMP/beta-CD inclusion complex. The formation of this multilayer 2D nanosheet based on the self assembly of SMP/beta-CD inclusion complexes is proposed by the topological transformation as well as molecular modeling calculations. But, nanorods are formed in SMP/alpha-CD inclusion complex indicated that the nature of the CD determined the shape of the self assembled supramolecular architecture. The formation of nanomaterial was characterized by using FT-IR, DSC, PXRD, (1)H NMR, absorption, fluorescence and lifetime measurements.
[Enzyme immunoassay for determination of sulfamethoxypyridazine in honey].[Pubmed:20391769]
Prikl Biokhim Mikrobiol. 2010 Mar-Apr;46(2):232-6.
An enzyme immunoassay technique for the detection of Sulfamethoxypyridazine in honey, developed using rabbit polyclonal antibodies raised against N-sulfonyl-4-aminobutyric acid, which contains a structural group characteristic of sulfonamides, is proposed. Under the optimized conditions, the Sulfamethoxypyridazine detection limit was 0.05 ng/ml, with the entire analysis procedure taking 2 h. In total, 24 honey samples were tested using the protocol based on tenfold dilutions of samples without their preliminary treatment.
Photolysis of sulfamethoxypyridazine in various aqueous media: aerobic biodegradation and identification of photoproducts by LC-UV-MS/MS.[Pubmed:23183348]
J Hazard Mater. 2013 Jan 15;244-245:654-61.
Sulfonamides are one of the most frequently used antibiotics worldwide. Therefore, mitigation processes such as abiotic or biotic degradation are of interest. Photodegradation and biodegradation are the potentially significant removal mechanisms for pharmaceuticals in aquatic environments. The photolysis of Sulfamethoxypyridazine (SMP) using a medium pressure Hg-lamp was evaluated in three different media: Millipore water pH 6.1 (MW), effluent from sewage treatment plant pH 7.6 (STP), and buffered demineralized water pH 7.4 (BDW). Identification of transformation products (TPs) was performed by LC-UV-MS/MS. The biodegradation of SMP using two tests from the OECD series was studied: Closed Bottle test (OECD 301 D), and Manometric Respirometry test (OECD 301 F). In biodegradation tests, it was found that SMP was not readily biodegradable so it may pose a risk to the environment. The results showed that SMP was removed completely within 128 min of irradiation in the three media, and the degradation rate was different for each investigated type of water. However, dissolved organic carbon (DOC) was not removed in BDW and only little DOC removal was observed in MW and STP, thus indicating the formation of TPs. Analysis by LC-UV-MS/MS revealed new TPs formed. The hydroxylation of SMP represents the main photodegradation pathway.
Advantages of soybean peroxidase over horseradish peroxidase as the enzyme label in chemiluminescent enzyme-linked immunosorbent assay of sulfamethoxypyridazine.[Pubmed:20175541]
J Agric Food Chem. 2010 Mar 24;58(6):3284-9.
An indirect competitive chemiluminescent enzyme-linked immunosorbent assay (CL-ELISA) of Sulfamethoxypyridazine (SMP) was developed. The conjugates of streptavidin with cationic horseradish peroxidase (HRP) and anionic soybean peroxidase (SbP) were used in CL-ELISA for the detection of biotinylated anti-SMP antibodies. For streptavidin-HRP conjugate-catalyzed chemiluminescence measured 20 s after the initiation of the enhanced chemiluminescence reaction (ECR), the limit of detection (IC(10)), the IC(50) value, and the working range in CL-ELISA of SMP are 0.3, 12.4, and 1.2-85.0 ng/mL, respectively. An increase in the time interval between the ECR initiation and the luminescence measurement results in the loss in the quality of analytical measurements because of the time-dependent quenching of chemiluminescence typical of the HRP-catalyzed ECR. In the case of SbP-based CL-ELISA of SMP, the limit of detection, the IC(50) value, and the working range (0.025, 0.17, and 0.045-0.63 ng/mL, respectively) are better than those for HRP-based CL-ELISA. Furthermore, the analytical parameters of SbP-based CL-ELISA remain unchanged during a long period of time (for at least 30 min). The recovery values from four spiked milk samples with different concentrations of SMP in SbP-based CL-ELISA vary from 70 to 130%.
