(+)-SophoranolCAS# 3411-37-8 |
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
| Cas No. | 3411-37-8 | SDF | Download SDF |
| PubChem ID | 3083801 | Appearance | Cryst. |
| Formula | C15H24N2O2 | M.Wt | 264.4 |
| Type of Compound | Alkaloids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| SMILES | C1CC2C3CCCN4C3C(CCC4)(CN2C(=O)C1)O | ||
| Standard InChIKey | VQYBAEAOOJBSTR-HKTMVNTCSA-N | ||
| Standard InChI | InChI=1S/C15H24N2O2/c18-13-6-1-5-12-11-4-2-8-16-9-3-7-15(19,14(11)16)10-17(12)13/h11-12,14,19H,1-10H2/t11?,12?,14?,15-/m1/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | 1. (+)-Sophoranol exhibits antiviral activity against the Coxsackie virus B3. 2. (+)-Sophoranol shows potent anti-HBV activity with an inhibitory potency against HBsAg secretion and against HBeAg secretion. |
| Targets | HBV |
(+)-Sophoranol Dilution Calculator
(+)-Sophoranol Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 3.7821 mL | 18.9107 mL | 37.8215 mL | 75.643 mL | 94.5537 mL |
| 5 mM | 0.7564 mL | 3.7821 mL | 7.5643 mL | 15.1286 mL | 18.9107 mL |
| 10 mM | 0.3782 mL | 1.8911 mL | 3.7821 mL | 7.5643 mL | 9.4554 mL |
| 50 mM | 0.0756 mL | 0.3782 mL | 0.7564 mL | 1.5129 mL | 1.8911 mL |
| 100 mM | 0.0378 mL | 0.1891 mL | 0.3782 mL | 0.7564 mL | 0.9455 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Quinolizidine alkaloids with anti-HBV activity from Sophora tonkinensis.[Pubmed:16783704]
Planta Med. 2006 Jul;72(9):854-6.
A new matrine-type alkaloid, (-)-14 beta-hydroxyoxymatrine (1), was isolated from the roots and rhizomes of Sophora tonkinensis Gapnep. (Leguminosae), together with five known matrine-type alkaloids, (-)-14 beta-hydroxymatrine (2), (+)-oxymatrine (3), (+)-matrine (4), (+)-Sophoranol (5), and (-)-5 alpha-hydroxysophocarpine ( 6), as well as with two known cytisine-type alkaloids, (-)-cytisine (7) and (-)- N-methylcytisine (8). Their structures were elucidated by spectroscopic methods. Compounds 1, 5 and 7 showed potent anti-HBV activity with an inhibitory potency against HBsAg secretion of 22.6 %, 31.1 % and 33.2 %, and against HBeAg secretion of 30.4 %, 26.3 % and 27.8 %, respectively.
Antiviral Matrine-Type Alkaloids from the Rhizomes of Sophora tonkinensis.[Pubmed:26132528]
J Nat Prod. 2015 Jul 24;78(7):1683-8.
Three new matrine-type alkaloids, (+)-5alpha-hydroxyoxysophocarpine (1), (-)-12beta-hydroxyoxysophocarpine (2), and (+)-5alpha-hydroxylemannine (3), along with 14 known analogues, (-)-sophocarpine (4), (-)-5alpha-hydroxysophocarpine (5), (-)-9alpha-hydroxysophocarpine (6), (+)-12alpha-hydroxysophocarpine (7), (-)-12beta-hydroxysophocarpine (8), (+)-oxysophocarpine (9), (+)-matrine (10), (+)-Sophoranol (11), (+)-9alpha-hydroxymatrine (12), (-)-14beta-hydroxymatrine (13), (+)-oxymatrine (14), (+)-5alpha-hydroxyoxymatrine (15), (-)-14beta-hydroxyoxymatrine (16), and (+)-sophoramine (17), were isolated from the rhizomes of Sophora tonkinensis. Their structures were elucidated via spectrometric data analyses, and the absolute configurations were established by single-crystal X-ray diffraction and ECD data. Alkaloids 2, 6, 11, and 13 exhibited antiviral activity against the Coxsackie virus B3 (CVB3), with IC50 values of 26.62-252.18 muM, and alkaloids 7, 8, and 17 inhibited influenza virus A/Hanfang/359/95 (H3N2) replication with IC50 values of 63.07-242.46 muM.
