Shizukaol A

CAS# 131984-98-0

Shizukaol A

Catalog No. BCN6984----Order now to get a substantial discount!

Product Name & Size Price Stock
Shizukaol A:5mg Please Inquire In Stock
Shizukaol A:10mg Please Inquire In Stock
Shizukaol A:20mg Please Inquire In Stock
Shizukaol A:50mg Please Inquire In Stock

Quality Control of Shizukaol A

Number of papers citing our products

Chemical structure

Shizukaol A

3D structure

Chemical Properties of Shizukaol A

Cas No. 131984-98-0 SDF Download SDF
PubChem ID 127045559 Appearance Powder
Formula C31H34O6 M.Wt 502.60
Type of Compound Sesquiterpenoids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
SMILES CC1=C2CC3C(=C)C4CC4C3(C5C2(C6C7=C(C5)C8CC8C7(C(C(=O)C6=C(C)C(=O)OC)O)C)OC1=O)C
Standard InChIKey GQSUZVYXPAKHQW-SFVFYCNCSA-N
Standard InChI InChI=1S/C31H34O6/c1-11-14-7-19(14)29(4)17(11)10-18-12(2)28(35)37-31(18)21(29)9-16-15-8-20(15)30(5)23(16)24(31)22(25(32)26(30)33)13(3)27(34)36-6/h14-15,17,19-21,24,26,33H,1,7-10H2,2-6H3/b22-13-/t14-,15-,17+,19-,20-,21+,24+,26+,29-,30+,31+/m1/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Shizukaol A

The roots of Chloranthus japonicus.

Biological Activity of Shizukaol A

DescriptionShizukaol A is a natural product from Chloranthus japonicus.

Protocol of Shizukaol A

Structure Identification
Phytochemistry, 1990, 29(7):2332-2334.

Shizukaol a, a sesquiterpene dimer from Chloranthus japonicus.[Reference: WebLink]

Shizukaol A, a novel dimeric sesquiterpene consisted of two lindenane (modified eudesmane) units was isolated from roots of Chloranthus japonicus. The structure was elucidated by 1D and 2D NMR analyses and by chemical methods.

Shizukaol A Dilution Calculator

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Shizukaol A Molarity Calculator

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Preparing Stock Solutions of Shizukaol A

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.9897 mL 9.9483 mL 19.8965 mL 39.7931 mL 49.7413 mL
5 mM 0.3979 mL 1.9897 mL 3.9793 mL 7.9586 mL 9.9483 mL
10 mM 0.199 mL 0.9948 mL 1.9897 mL 3.9793 mL 4.9741 mL
50 mM 0.0398 mL 0.199 mL 0.3979 mL 0.7959 mL 0.9948 mL
100 mM 0.0199 mL 0.0995 mL 0.199 mL 0.3979 mL 0.4974 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Shizukaol A

[Sesquiterpenes with anti-metastasis breast cancer activity from Chloranthus henryi].[Pubmed:29243431]

Zhongguo Zhong Yao Za Zhi. 2017 Oct;42(20):3938-3944.

To study sesquiterpenes with anti-metastasis breast cancer activity from Chloranthus henryi, ten sesquiterpenes ,zedoarofuran (1), chlorajapolide D (2), 4beta, 8beta-dihydroxy-5alpha(H)-eudesm-7(11)-en-8, 12-olide (3), curcolonol (4), lasianthuslactone A (5), chlomultin C (6), (1E,4Z)-8-hydroxy-6-oxogermacra-1(10), 4, 7(11) -trieno-12, 8-lactone (7), shizukanolide E (8) , shizukanolide F (9) , 9alpha-hydroxycurcolonol (10), and five bis-sesquiterpenes, shizukaol B (11), shizukaol C (12) , cycloShizukaol A (13) , sarcandrolide B (14) , henriol A(15), were isolated by using different kinds of column chromatography methods from the ethyl acetate part of Ch.henryi and their structures were identified based on spectroscopic methods. Compounds 2, 8, 9, and 10 were obtained from the genus Chloranthus for the first time. Compounds 2, 5, 8-10, 12,and 14 were obtained from this plant for the first time. Some isolated compounds were subjected to evaluate the anti-metastasis breast cancer activity by using pharmacological methods, and only compounds 4, 11, and 12 were potent active.

Spicachlorantins G-J, new lindenane sesquiterpenoid dimers from the roots of Chloranthus spicatus.[Pubmed:21963639]

Chem Pharm Bull (Tokyo). 2011;59(10):1281-4.

Four new lindenane sesquiterpenoid dimers, spicachlorantins G-J (1-4), were isolated from the roots of Chloranthus spicatus together with seven known compounds, including chloramultilide A, shizukaol B, shizukaol D, shizukaol F, shizukaol P, chlorahololide D, and cycloShizukaol A. The planar structures of the new compounds were established by 1D-, 2D-NMR, and MS analyses. The absolute configurations of these compounds were determined by analyzing rotating Overhauser enhancement and exchange spectroscopy (ROESY) and circular dichroism (CD) spectra.

Terpenoids from Chloranthus multistachys.[Pubmed:18855217]

Nat Prod Res. 2008;22(13):1163-8.

Two new diterpenoids, ent-17-hydroxyl-16beta-methoxyl-kauran-3-one (1) and ent-17-acetoxyl-16beta-methoxyl-kauran-3-one (2), along with nine known compounds (3-12), ent-17-hydroxyl-kaur-15-en-3-one (3), ent-3beta-acetoxyl-kaur-15-en-16beta, 17-diol (4), ent-kauran-3beta, 16beta, 17-triol (5), ent-3beta-acetoxyl-kauran-16beta, 17-diol (6), ent-kauran-16beta, 17-diol (7), abbeokutone (8), ent-17alpha-acetyl-16beta-hydroxyl- kauran-3-one (9), shizukaol F (10), cycloShizukaol A (11) and curcolonol (12), were isolated from Chloranthus multistachys (Chloranthaceae). Their structures were elucidated by spectroscopic spectra.

Dimeric sesquiterpenoids isolated from Chloranthus japonicus inhibited the expression of cell adhesion molecules.[Pubmed:16229979]

J Ethnopharmacol. 2006 Mar 8;104(1-2):270-7.

In the search for cell adhesion inhibitors from natural sources, three active compounds were isolated from Chloranthus japonicus Sieb. (Chloranthaceae) roots. The compounds were identified as dimeric sesquiterpenoids of shizukaol B (1), cycloShizukaol A (2) and shizukaol F (3). These compounds inhibited PMA-induced homotypic aggregation of HL-60 cells without cytotoxicity with MIC values of 34.1 nM (1), 0.9 microM (2) and 27.3 nM (3), respectively. Although 1-3 did not affect the direct binding of LFA-1 to ICAM-1, these compounds markedly inhibited ICAM-1 expression in HL-60 cells in a dose-dependent fashion. On the other hand, when HUVEC were pretreated with 1-3 and stimulated with TNF-alpha, adhesion of THP-1 cells to HUVEC decreased in dose-dependent manner with IC(50) values of 54.6 nM, 1.2 microM and 34.1 nM, respectively. In fact, 1 inhibited TNF-alpha-induced surface expression of the ICAM-1, VCAM-1 and E-selectin in HUVEC with IC(50) values of 5.4 nM, 13.6 microM and 95.6 nM, respectively. The present findings suggest that 1-3 prevent monocyte adhesion to HUVEC through the inhibition of cell adhesion molecules expression stimulated by TNF-alpha.

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