Scutebata BCAS# 1207181-58-5 |
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
| Cas No. | 1207181-58-5 | SDF | Download SDF |
| PubChem ID | 46183385 | Appearance | Powder |
| Formula | C35H39NO10 | M.Wt | 633.7 |
| Type of Compound | Diterpenoids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | [(1R,2S,3R,4S,4aS,8aR)-4-[(1S)-1-acetyloxy-2-(4-hydroxy-5-oxo-2H-furan-3-yl)ethyl]-2-benzoyloxy-3-hydroxy-3,4,8,8a-tetramethyl-2,4a,5,6-tetrahydro-1H-naphthalen-1-yl] pyridine-3-carboxylate | ||
| SMILES | CC1=CCCC2C1(C(C(C(C2(C)C(CC3=C(C(=O)OC3)O)OC(=O)C)(C)O)OC(=O)C4=CC=CC=C4)OC(=O)C5=CN=CC=C5)C | ||
| Standard InChIKey | PMRCLNAMSQXGTL-MJSWBYPNSA-N | ||
| Standard InChI | InChI=1S/C35H39NO10/c1-20-11-9-15-25-33(20,3)28(45-31(40)23-14-10-16-36-18-23)29(46-30(39)22-12-7-6-8-13-22)35(5,42)34(25,4)26(44-21(2)37)17-24-19-43-32(41)27(24)38/h6-8,10-14,16,18,25-26,28-29,38,42H,9,15,17,19H2,1-5H3/t25-,26-,28-,29-,33-,34-,35-/m0/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | Scutebata B inhibited NO production efficiently with IC50 values of lower than 50 μM. |
| Targets | NO |
| In vitro | Constituents from Scutellaria barbata Inhibiting Nitric Oxide Production in LPS-Stimulated Microglial Cells.[Reference: WebLink]Chemistry & Biodiversity, 2017, 14(11).
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| Structure Identification | Journal of Natural Products, 2010, 73(2):233-236.Cytotoxic neoclerodane diterpenoids from Scutellaria barbata.[Reference: WebLink]
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Scutebata B Dilution Calculator
Scutebata B Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 1.578 mL | 7.8902 mL | 15.7803 mL | 31.5607 mL | 39.4508 mL |
| 5 mM | 0.3156 mL | 1.578 mL | 3.1561 mL | 6.3121 mL | 7.8902 mL |
| 10 mM | 0.1578 mL | 0.789 mL | 1.578 mL | 3.1561 mL | 3.9451 mL |
| 50 mM | 0.0316 mL | 0.1578 mL | 0.3156 mL | 0.6312 mL | 0.789 mL |
| 100 mM | 0.0158 mL | 0.0789 mL | 0.1578 mL | 0.3156 mL | 0.3945 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Neoclerodane diterpenoids from Scutellaria barbata with cytotoxic activities.[Pubmed:30449170]
Nat Prod Res. 2018 Nov 19:1-7.
Two new neoclerodane diterpenoids, barbatin F (1), barbatin G (2) together with four known compounds, scutebata A (3), Scutebata B (4), scutebata C (5) and scutebata P (6) were isolated from the whole plant of Scutellaria barbata D.Don. Their structures were elucidated on the basis of spectroscopic studies. In vitro cytotoxicity of selected compounds against cancer cell lines LoVo, SMMC-7721, HCT-116, and MCF-7 were evaluated, compound 1 and 2 showed weak cytotoxic activities against HCT-116 colon cancer cell lines with IC50 value of 44.3, 32.3 muM, respectively, while compound 3 and 4 exhibited moderate cytotoxic activities against four tested human cancer cell lines with IC50 values of 5.3128.5 muM.
