(-)-Sativan

CAS# 41743-86-6

(-)-Sativan

Catalog No. BCN7752----Order now to get a substantial discount!

Product Name & Size Price Stock
(-)-Sativan:5mg Please Inquire In Stock
(-)-Sativan:10mg Please Inquire In Stock
(-)-Sativan:20mg Please Inquire In Stock
(-)-Sativan:50mg Please Inquire In Stock
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Quality Control of (-)-Sativan

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Chemical structure

(-)-Sativan

3D structure

Chemical Properties of (-)-Sativan

Cas No. 41743-86-6 SDF Download SDF
PubChem ID 170570 Appearance Powder
Formula C17H18O4 M.Wt 286.32
Type of Compound Flavonoids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name (3R)-3-(2,4-dimethoxyphenyl)-3,4-dihydro-2H-chromen-7-ol
SMILES COC1=CC(=C(C=C1)C2CC3=C(C=C(C=C3)O)OC2)OC
Standard InChIKey TUXCLJQCYVCGDW-LBPRGKRZSA-N
Standard InChI InChI=1S/C17H18O4/c1-19-14-5-6-15(17(9-14)20-2)12-7-11-3-4-13(18)8-16(11)21-10-12/h3-6,8-9,12,18H,7,10H2,1-2H3/t12-/m0/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of (-)-Sativan

The leaves of birdsfoot trefoil.

Biological Activity of (-)-Sativan

Description1. (-)-Sativan is a phytoalexin.

(-)-Sativan Dilution Calculator

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(-)-Sativan Molarity Calculator

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Preparing Stock Solutions of (-)-Sativan

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.4926 mL 17.463 mL 34.926 mL 69.8519 mL 87.3149 mL
5 mM 0.6985 mL 3.4926 mL 6.9852 mL 13.9704 mL 17.463 mL
10 mM 0.3493 mL 1.7463 mL 3.4926 mL 6.9852 mL 8.7315 mL
50 mM 0.0699 mL 0.3493 mL 0.6985 mL 1.397 mL 1.7463 mL
100 mM 0.0349 mL 0.1746 mL 0.3493 mL 0.6985 mL 0.8731 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on (-)-Sativan

The Chemical Components of Sesbania grandiflora Root and Their Antituberculosis Activity.[Pubmed:24280680]

Pharmaceuticals (Basel). 2012 Aug 23;5(8):882-9.

Three isoflavanoids, isovestitol (1), medicarpin (2), and (-)-Sativan (3), along with another known compound, betulinic acid (4), were isolated from the root of Sesbania grandiflora. The structures of the isolated compounds were characterised by means of spectroscopic techniques (UV, IR, MS, 1H- and 13C-NMR, DEPT, COSY, HMQC, HMBC, and MS analysis). All the tested compounds 1-4 exhibited antituberculosis activity against Mycobacterium tuberculosis H37Rv, with MIC values of 50 microg/mL for compounds 1-3, and 100 microg/mL for compound 4, whereas, the methanol extract exhibited antituberculosis activity of 625 microg/mL. This is the first report on the occurrence of isoflavonoids in this plant and their antituberculosis activity.

The effect of sativan from Viola verecunda A. Gray on the expressions of matrix metalloproteinase-1 caused by ultraviolet irradiated cultured primary human skin fibroblasts.[Pubmed:16207520]

J Ethnopharmacol. 2006 Mar 8;104(1-2):12-7.

Matrix metalloproteinases (MMPs) are a family of enzymes whose main function is degradation of the extracellular matrix. Matrix metalloproteinase-1 (MMP-1) degrades type I procollagen constituting the major structural component of the basement membrane and extra cellular membrane. The enzymatic activity is found to be elevated in photoaging. With the aim of finding novel MMP-1 inhibitors from natural products, 15 extracts of the Viola taxa, which are used as prescriptions for skin eruption treatment in traditional medicine, were screened for their inhibitory activities towards MMP-1. Among the 15 tested materials, the methanol extracts of Viola hondoensis W. BECKER et H. BOISS, Viola ibukiana MAKINO, Viola lactiflora NAKAI and Viola verecunda A. GRAY were potential inhibitory to MMP-1, and other Viola taxa showed a weak inhibitory effect at a concentration of 100 microg/ml. We investigated the effect of MMP-1 inhibitory of the solvent fractions of the same plants (Viola hondoensis, Viola ibukiana and Viola verecunda). Therefore, a strong inhibition was found in the ethylacetate fractions of Viola verecunda with inhibitory activity (>90%) at a concentration of 10 microg/ml. Here we investigated the effect of (-)-Sativan isolated from the ethylacetate fractions of Viola verecunda on the expression of MMPs in UV-irradiated human skin fibroblasts in vitro. (-)-Sativan markedly reduced UV-induced MMP-1 expression at the protein levels in a dose-dependent manner. Our report is the first description for the ability of (-)-Sativan to regulate UV-induced MMP-1 expression.

Susceptibility of zoopathogenic fungi to phytoalexins.[Pubmed:7387136]

Antimicrob Agents Chemother. 1980 Feb;17(2):120-3.

Phytoalexins are a group of low-molecular-weight antibiotics produced by higher plants in response to infection by relatively avirulent microorganisms. They are of relatively low toxicity for mammalian cells and have been reported to possess a broad spectrum of antimicrobial activity against bacteria and phytopathogenic fungi. Employing a broth dilution technique, we have found the zoopathogens Petriellidium boydii, Aspergillus flavus, A. fumigatus, Candida albicans, Coccidioides immitis, Cryptococcus neoformans, Histoplasma capsulatum, Rhizopus oryzae, Sporothrix schenckii, and Trichophyton rubrum to be inhibited by one or more of the phytoalexins maackiain, medicarpin, phaseollin, phaseollin isoflavan, pisatin, (-)-Sativan, and vestitol in concentrations of from 12.5 to 50 microgram/ml. Phaseollin isofalvan was the most effective of these. In agar cup diffusion tests growth of the yeast form of Blastomyces dermatitidis was inhibited by phaseollin at 50 microgram/ml and by phaseollin isoflavan at 25 microgram/ml. Susceptibility of the mycelial form of B. dermatitidis to these two compounds was demonstrated by inhibition of radial extension on agar plates.

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