MnTBAP ChlorideCell-permeable superoxide dismutase mimetic CAS# 55266-18-7 |
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Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
| Cas No. | 55266-18-7 | SDF | Download SDF |
| PubChem ID | 124080981 | Appearance | Powder |
| Formula | C48H28ClMnN4O8 | M.Wt | 879.15 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Solubility | >25.4mg/ml in DMSO | ||
| Chemical Name | 4-[10,15-bis(4-carboxylatophenyl)-20-(4-carboxyphenyl)-21,24-dihydroporphyrin-5-yl]benzoate;manganese(3+);hydrochloride | ||
| SMILES | C1=CC(=CC=C1C2=C3C=CC(=C(C4=NC(=C(C5=NC(=C(C6=CC=C2N6)C7=CC=C(C=C7)C(=O)[O-])C=C5)C8=CC=C(C=C8)C(=O)[O-])C=C4)C9=CC=C(C=C9)C(=O)[O-])N3)C(=O)O.Cl.[Mn+3] | ||
| Standard InChIKey | ZLTXWWFMHDMCGZ-UHFFFAOYSA-K | ||
| Standard InChI | InChI=1S/C48H30N4O8.ClH.Mn/c53-45(54)29-9-1-25(2-10-29)41-33-17-19-35(49-33)42(26-3-11-30(12-4-26)46(55)56)37-21-23-39(51-37)44(28-7-15-32(16-8-28)48(59)60)40-24-22-38(52-40)43(36-20-18-34(41)50-36)27-5-13-31(14-6-27)47(57)58;;/h1-24,49-50H,(H,53,54)(H,55,56)(H,57,58)(H,59,60);1H;/q;;+3/p-3 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
MnTBAP Chloride Dilution Calculator
MnTBAP Chloride Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 1.1375 mL | 5.6873 mL | 11.3746 mL | 22.7492 mL | 28.4366 mL |
| 5 mM | 0.2275 mL | 1.1375 mL | 2.2749 mL | 4.5498 mL | 5.6873 mL |
| 10 mM | 0.1137 mL | 0.5687 mL | 1.1375 mL | 2.2749 mL | 2.8437 mL |
| 50 mM | 0.0227 mL | 0.1137 mL | 0.2275 mL | 0.455 mL | 0.5687 mL |
| 100 mM | 0.0114 mL | 0.0569 mL | 0.1137 mL | 0.2275 mL | 0.2844 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Superoxide (O(2)(·-)) is the proximal mitochondrial reactive oxygen species underlying pathology and redox signaling. This central role prioritizes development of a mitochondria-targeted reagent selective for controlling O(2)(·-). MnTBAP is a novel, stable and cell-permeable superoxide dismutase mimetic.
In vitro: Due to its superoxide dismutase mimetic property, 50 microM MnTBAP was found to attenuate the injury produced dose-dependently by exposure to various concentrations of paraquat for 4 h. MnTBAP also protected endothelial cells in a dose-dependent manner against paraquat. The protective effect of MnTBAP appears to be caused by its intracellular superoxide-scavenging activity because neither the zinc form nor CuZnSOD protected the cells against paraquat-induced injury [1].
In vivo: Local administration of MnTBAP significantly and reduced carrageenan-induced paw oedema dose-dependently at all time points, which was related to its superoxide dismutase mimetic property. MnTBAP also caused a significant dose-dependent reduction in paw myeloperoxidase activity, as well as preventing histological injury. Immunohistochemical analyses for nitrotyrosine showed a positive staining in paw from carrageenan-treated rats [2].
Clinical trial: Up to now, MnTBAP is still in the preclinical development stage.
References:
[1] Day BJ, Shawen S, Liochev SI, Crapo JD. A metalloporphyrin superoxide dismutase mimetic protects against paraquat-induced endothelial cell injury, in vitro. J Pharmacol Exp Ther. 1995 Dec;275(3):1227-32.
[2] Cuzzocrea S, Costantino G, Mazzon E, Zingarelli B, De Sarro A, Caputi AP. Protective effects of Mn(III)tetrakis (4-benzoic acid) porphyrin (MnTBAP), a superoxide dismutase mimetic, in paw oedema induced by carrageenan in the rat. Biochem Pharmacol. 1999 Jul 1;58(1):171-6.
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