Methylgomisin OCAS# 1276654-07-9 |
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
| Cas No. | 1276654-07-9 | SDF | Download SDF |
| PubChem ID | 46192500 | Appearance | Powder |
| Formula | C24H30O7 | M.Wt | 430.5 |
| Type of Compound | Lignans | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | (8R,9S,10S)-3,4,5,8,19-pentamethoxy-9,10-dimethyl-15,17-dioxatetracyclo[10.7.0.02,7.014,18]nonadeca-1(19),2,4,6,12,14(18)-hexaene | ||
| SMILES | CC1CC2=CC3=C(C(=C2C4=C(C(=C(C=C4C(C1C)OC)OC)OC)OC)OC)OCO3 | ||
| Standard InChIKey | FCFAWFPHAOTXPJ-KQHSUYLTSA-N | ||
| Standard InChI | InChI=1S/C24H30O7/c1-12-8-14-9-17-22(31-11-30-17)23(28-6)18(14)19-15(20(26-4)13(12)2)10-16(25-3)21(27-5)24(19)29-7/h9-10,12-13,20H,8,11H2,1-7H3/t12-,13-,20+/m0/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | Methylgomisin O has anti- inflammatory activity, it -induced attenuation of inflammatory cytokine production upon exposure to LPS was at least partially mediated by the suppression of NF-κB and MAPK pathway. Methylgomisin O exhibits strong cytotoxic effects on HL-60. It exhibits considerable inhibitory activity against tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6). |
| Targets | NF-κB | MAPK | TNF-α | IL Recepter |
| In vitro | Anti-inflammatory effect and mechanism of methylgomisin O.[Reference: WebLink]Chinese journal of veterinary science, 2011, 31(9):1309-1308.Methylgomisin O was a new dibenzocyclooctadiene lignan isolated from the fruits of Schisandra sphenanthera.
The Antiproliferative Effects of Compounds Isolated from Schisandra chinensis.[Reference: WebLink]Korean journal of food science & technology, 2014, 46(6):665-670.We isolated twelve lignans and three terpenoids were isolated from the n-hexane fraction of Schisandra chinensis extract. New Dibenzocyclooctadiene Lignans from Schisandra sphenanthera and Their Proinflammatory Cytokine Inhibitory Activities.[Reference: WebLink]Zeitschrift Für Naturforschung B, 2010, 65(2):1-8.
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Methylgomisin O Dilution Calculator
Methylgomisin O Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.3229 mL | 11.6144 mL | 23.2288 mL | 46.4576 mL | 58.072 mL |
| 5 mM | 0.4646 mL | 2.3229 mL | 4.6458 mL | 9.2915 mL | 11.6144 mL |
| 10 mM | 0.2323 mL | 1.1614 mL | 2.3229 mL | 4.6458 mL | 5.8072 mL |
| 50 mM | 0.0465 mL | 0.2323 mL | 0.4646 mL | 0.9292 mL | 1.1614 mL |
| 100 mM | 0.0232 mL | 0.1161 mL | 0.2323 mL | 0.4646 mL | 0.5807 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Isolation and anti-hepatitis B virus activity of dibenzocyclooctadiene lignans from the fruits of Schisandra chinensis.[Pubmed:25882501]
Phytochemistry. 2015 Aug;116:253-261.
Seven lignans with a dibenzocyclooctadiene skeleton, termed schinlignans A-G, and a 6,7-seco-homolignan, schischinone, together with seven known lignans, were isolated from the fruits of Schisandra chinensis (Turcz.) Baill. Their structures were elucidated by extensive spectroscopic methods, including HRESIMS, IR, UV, and 2D NMR (COSY, HMQC, COSY, and HMBC experiments). The stereochemistry at the chiral centers and the biphenyl moiety, were determined using ROESY, as well as via interpretation of their ECD spectra. Schinlignan G and Methylgomisin O exhibited potent anti-hepatitis B virus activity against HBV DNA replication with IC50 values of 5.13 and 5.49mugmL(-1), respectively.
