MesuolCAS# 16981-20-7 |
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
| Cas No. | 16981-20-7 | SDF | Download SDF |
| PubChem ID | 5277586 | Appearance | Yellow powder |
| Formula | C24H24O5 | M.Wt | 392.5 |
| Type of Compound | Coumarins | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | 5,7-dihydroxy-8-(3-methylbut-2-enyl)-6-(2-methylpropanoyl)-4-phenylchromen-2-one | ||
| SMILES | CC(C)C(=O)C1=C(C2=C(C(=C1O)CC=C(C)C)OC(=O)C=C2C3=CC=CC=C3)O | ||
| Standard InChIKey | IWUNXYBEJCJQHB-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C24H24O5/c1-13(2)10-11-16-22(27)20(21(26)14(3)4)23(28)19-17(12-18(25)29-24(16)19)15-8-6-5-7-9-15/h5-10,12,14,27-28H,11H2,1-4H3 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | 1. Mesuol can suppress HIV-1 replication in Jurkat T cells, it inhibits TNFα-induced HIV-1-LTR transcriptional activity by targeting the nuclear factor-κB (NF-κB) pathway. 2. Mesuol has immunomodulatory activity, it can potentiate percentage neutrophil adhesion in neutrophil adhesion test in rats and phagocytosis in carbon clearance assay. 3. Mesuol has antioxidant activity, it shows very high scavenging activity against DPPH radical. |
| Targets | HIV | NF-kB |
Mesuol Dilution Calculator
Mesuol Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.5478 mL | 12.7389 mL | 25.4777 mL | 50.9554 mL | 63.6943 mL |
| 5 mM | 0.5096 mL | 2.5478 mL | 5.0955 mL | 10.1911 mL | 12.7389 mL |
| 10 mM | 0.2548 mL | 1.2739 mL | 2.5478 mL | 5.0955 mL | 6.3694 mL |
| 50 mM | 0.051 mL | 0.2548 mL | 0.5096 mL | 1.0191 mL | 1.2739 mL |
| 100 mM | 0.0255 mL | 0.1274 mL | 0.2548 mL | 0.5096 mL | 0.6369 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Mesuol, a natural occurring 4-phenylcoumarin, inhibits HIV-1 replication by targeting the NF-kappaB pathway.[Pubmed:15911030]
Antiviral Res. 2005 Jun;66(2-3):137-45.
Coumarins and structurally related compounds have been recently shown to inhibit replication of human immunodeficiency virus (HIV) and thus, exhibit a therapeutic potential. In this study we report that Mesuol and isoMesuol, two 4-phenyl coumarins, isolated from the tree Marila pluricostata, suppress HIV-1 replication in Jurkat T cells. These coumarins do not affect the reverse transcription and integration steps of the viral cycle and their antiviral effect is additive with that of azidothymidine (AZT). In addition, Mesuol inhibits TNFalpha-induced HIV-1-LTR transcriptional activity by targeting the nuclear factor-kappaB (NF-kappaB) pathway. While Mesuol does not prevent either the binding of NF-kappaB to DNA or the phosphorylation and degradation of NF-kappaB inhibitory protein, IkappaBalpha, it inhibits the phosphorylation and the transcriptional activity of the NF-kappaB p65 subunit in TNFalpha-stimulated cells. These results highlight the potential of the NF-kappaB transcription factor as a target for anti-HIV-1 compounds such as 4-phenyl coumarins, which could serve as lead compounds for the development of additional therapeutic approaches against AIDS.
In-vivo antioxidant and immunomodulatory activity of mesuol isolated from Mesua ferrea L. seed oil.[Pubmed:22634479]
Int Immunopharmacol. 2012 Aug;13(4):386-91.
Mesua ferrea L. (Nagkesar) is traditionally being used for antiseptic, anti-inflammatory, antiasthmatic and antiallergic activities. It is an ingredient of ayurvedic formulations like Brahma Rasayana and Chyavanprash which are being used to improve immunity. The present study was performed to evaluate immunomodulatory activity of Mesuol isolated from M. ferrea seed oil in experimental animals. In humoral immune response model, Mesuol evoked a significant dose dependent increase in antibody titer values in cyclophosphamide (50 mg/kg, i.p., 9th and 16th day) induced immunosuppression which was sensitized with sheep red blood cells (SRBC) on the 7th and 14th day of experiment. In cellular immune response model, an increase in paw volume was recorded on the 23rd day in cyclophosphamide-induced immunosuppressed rats treated with SRBC (0.03 ml 2% v/v, s.c.) on the 21st day. Mesuol restored the hematological profile in cyclophosphamide induced myelosuppression model. Mesuol potentiated percentage neutrophil adhesion in neutrophil adhesion test in rats and phagocytosis in carbon clearance assay. The study indicated immunomodulatory activity of Mesuol.
