Meliasenin B

CAS# 1221262-77-6

Meliasenin B

Catalog No. BCN6112----Order now to get a substantial discount!

Product Name & Size Price Stock
Meliasenin B:5mg Please Inquire In Stock
Meliasenin B:10mg Please Inquire In Stock
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Meliasenin B:50mg Please Inquire In Stock
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Chemical structure

Meliasenin B

3D structure

Chemical Properties of Meliasenin B

Cas No. 1221262-77-6 SDF Download SDF
PubChem ID 46210176 Appearance Powder
Formula C30H44O4 M.Wt 468.7
Type of Compound Triterpenoids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name (2S,4S,7R,8S,9S,12R,13R,16S,18R)-16-hydroxy-2,9,13,17,17-pentamethyl-7-(4-methylpent-3-enyl)-5-oxapentacyclo[10.8.0.02,9.04,8.013,18]icos-1(20)-ene-6,19-dione
SMILES CC(=CCCC1C2C(CC3(C2(CCC4C3=CC(=O)C5C4(CCC(C5(C)C)O)C)C)C)OC1=O)C
Standard InChIKey OWDAIHNVLSQWBW-SQAWLGPQSA-N
Standard InChI InChI=1S/C30H44O4/c1-17(2)9-8-10-18-24-22(34-26(18)33)16-30(7)20-15-21(31)25-27(3,4)23(32)12-13-28(25,5)19(20)11-14-29(24,30)6/h9,15,18-19,22-25,32H,8,10-14,16H2,1-7H3/t18-,19+,22+,23+,24-,25+,28-,29+,30-/m1/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Meliasenin B

The seeds of Melia azedarach L.

Biological Activity of Meliasenin B

Description1. Meliasenin B displays dose-dependent toxicity on HepG2 cells, suggests that it may cause hepatotoxicity.

Meliasenin B Dilution Calculator

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Meliasenin B Molarity Calculator

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Preparing Stock Solutions of Meliasenin B

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.1336 mL 10.6678 mL 21.3356 mL 42.6712 mL 53.339 mL
5 mM 0.4267 mL 2.1336 mL 4.2671 mL 8.5342 mL 10.6678 mL
10 mM 0.2134 mL 1.0668 mL 2.1336 mL 4.2671 mL 5.3339 mL
50 mM 0.0427 mL 0.2134 mL 0.4267 mL 0.8534 mL 1.0668 mL
100 mM 0.0213 mL 0.1067 mL 0.2134 mL 0.4267 mL 0.5334 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Meliasenin B

[Study on rapid screening and identifying hepatotoxic compounds in toosendan fructus].[Pubmed:24010303]

Zhongguo Zhong Yao Za Zhi. 2013 Jun;38(11):1820-2.

Fluorescein diacetate-labeled HepG2 cells model and flouresence automatic microscopy screening assay were used for fast screening 23 components from Toosendan Fructus, in which 5 components showed significant toxicity on HepG2 cells. The 10 compounds in the 2 components were tentatively identified with LC-MS(n), and 3 of them (Meliasenin B, trichilinin D and 1-O-tigloy-1-O-debenzoylohchinal) were prepared and identified. Further experiments showed that the 3 compounds displayed dose-dependent toxicity on HepG2 cells, suggesting that these compounds in Toosendan Fructus may cause hepatotoxicity.

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