Luteolin-4'-O-glucosideCAS# 6920-38-3 |
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
| Cas No. | 6920-38-3 | SDF | Download SDF |
| PubChem ID | 12304738 | Appearance | Powder |
| Formula | C21H20O11 | M.Wt | 448.38 |
| Type of Compound | Flavonoids | Storage | Desiccate at -20°C |
| Synonyms | Juncein; 3',4',5,7-Tetrahydroxyflavone 4'-glucoside | ||
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | 5,7-dihydroxy-2-[3-hydroxy-4-[(3~{R},4~{S},5~{S},6~{R})-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyphenyl]chromen-4-one | ||
| SMILES | C1=CC(=C(C=C1C2=CC(=O)C3=C(C=C(C=C3O2)O)O)O)OC4C(C(C(C(O4)CO)O)O)O | ||
| Standard InChIKey | UHNXUSWGOJMEFO-MKJMBMEGSA-N | ||
| Standard InChI | InChI=1S/C21H20O11/c22-7-16-18(27)19(28)20(29)21(32-16)31-13-2-1-8(3-10(13)24)14-6-12(26)17-11(25)4-9(23)5-15(17)30-14/h1-6,16,18-25,27-29H,7H2/t16-,18-,19+,20-,21?/m1/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | Luteolin 4'-O-glucoside as a IL-5 inhibitor, it has anti-complementary,and anti-oxdiant activities. |
| Targets | IL recepter |
| In vitro | In vitro anti-complementary activity of flavonoids from olive (Olea europaea L.) leaves.[Pubmed: 8941947]Pharmazie. 1996 Oct;51(10):765-8.
Isolation of Antioxidant and Antibrowning Substance from Chionanthus retusa Leaves[Reference: WebLink]Journal of the Korean Society of Food Science & Nutrition, 2004, 33(9).
Studies on anti-complementary activity of extracts and isolated flavones from Ligustrum vulgare and Phillyrea latifolia leaves (Oleaceae).[Pubmed: 10837985]J Ethnopharmacol. 2000 Jun;70(3):213-7.
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| Kinase Assay | Inhibitory effect of luteolin 4'-O-glucoside from Kummerowia striata and other flavonoids on interleukin-5 bioactivity.[Pubmed: 10418337 ]Planta Med. 1999 Jun;65(5):457-9.Interleukin (IL)-5 is a chemotactic factor of eosinophils, and promotes the growth and survival of eosinophils, which plays an important role in the eosinophilia-associated allergic inflammation.
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Luteolin-4'-O-glucoside Dilution Calculator
Luteolin-4'-O-glucoside Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.2303 mL | 11.1513 mL | 22.3025 mL | 44.605 mL | 55.7563 mL |
| 5 mM | 0.4461 mL | 2.2303 mL | 4.4605 mL | 8.921 mL | 11.1513 mL |
| 10 mM | 0.223 mL | 1.1151 mL | 2.2303 mL | 4.4605 mL | 5.5756 mL |
| 50 mM | 0.0446 mL | 0.223 mL | 0.4461 mL | 0.8921 mL | 1.1151 mL |
| 100 mM | 0.0223 mL | 0.1115 mL | 0.223 mL | 0.4461 mL | 0.5576 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Luteolin-4'-O-glucoside and its aglycone, two major flavones of Gnaphalium affine D. Don, resist hyperuricemia and acute gouty arthritis activity in animal models.[Pubmed:29519319]
Phytomedicine. 2018 Mar 1;41:54-61.
BACKGROUND: Gnaphalium affine D. Don is a folk medicine of China believed to be efficacious in the treatment of many ailments, including hyperuricemia and gout. PURPOSE: Based on a previous study, we isolated two flavones, luteolin and luteolin-4'-O-glucoside, from G. affine. Our aim was to assess the potential beneficial effects of treatment and mechanisms of these two flavones on hyperuricemia and acute gouty arthritis. METHODS: The model of potassium oxonate (PO)-induced hyperuricemia and monosodium urate (MSU) crystal-induced inflammation in mice has been established. We evaluated serum uric acid (Sur), xanthine oxidase (XO) activity, protein expression of urate transporter 1 (mURAT1) and glucose transporter 9 (mGLUT9) in renal and kidney protection in a hyperuricemia model. In addition, paw swelling and levels of interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) in serum were assessed in MSU crystal-induced mice. RESULTS: Luteolin and luteolin-4'-O-glucoside showed a potent clinical effect in treating hyperuricemia and gout. We observed that the two flavones possess potent effect in hyperuricemia mice by decreasing the level of mURAT1 and inhibiting XO activity, which contribute to enhancing uric acid (UA) excretion and improving hyperuricemia-induced renal dysfunction. In addition, luteolin and luteolin-4'-O-glucoside also alleviated paw swelling and inflammation induced by MSU crystals. Further investigation implied that luteolin and luteolin-4'-O-glucoside improved the symptoms of inflammation by decreasing the levels of IL-1beta and TNF-alpha. CONCLUSION: The present study suggests that luteolin and luteolin-4'-O-glucoside could be developed as therapeutics for treating hyperuricemia and gouty arthritis.
